A5100631211- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Trauma and Emergency Care Studies
- Spine and Intervertebral Disc Pathology
- Blood transfusion and management
- Cervical and Thoracic Myelopathy
- Spinal Fractures and Fixation Techniques
- Pelvic and Acetabular Injuries
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Medical Imaging and Analysis
- Vasculitis and related conditions
- Sepsis Diagnosis and Treatment
- Acute Myocardial Infarction Research
- Renal Diseases and Glomerulopathies
- Abdominal Trauma and Injuries
- Brain Metastases and Treatment
- Acute Kidney Injury Research
- Sirtuins and Resveratrol in Medicine
- Ocular Oncology and Treatments
- Management of metastatic bone disease
- Proteoglycans and glycosaminoglycans research
- Tendon Structure and Treatment
- Ultrasound and Hyperthermia Applications
- Systemic Sclerosis and Related Diseases
The University of Texas Health Science Center at Houston
2012-2025
Affiliated Hospital of Nantong University
2021-2024
National Taiwan University Hospital
2023
Xiyuan Hospital
2021-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2023
Nantong University
2021-2022
Zhengzhou University
2018-2022
Memorial Hermann
2020
Anna Needs Neuroblastoma Answers
2020
Xi'an Medical University
2014
Abstract Every year more than 500,000 deaths are attributed to trauma worldwide and severe hemorrhage is present in most of them. Transfused platelets have been shown improve survival patients, although its mechanism only partially known. Platelet derived-extracellular vesicles (PEVs) small released from upon activation and/or mechanical stimulation many the benefits could be mediated through PEVs. Based on available literature, we hypothesized that transfusion human PEVs would promote...
Abstract Introduction Trauma and hemorrhagic shock (T/HS) are associated with multiple organ injury. Antithrombin (AT) has anti-inflammatory protective activity through its interaction endothelial heparan sulfate containing a 3- O -sulfate modification. Our objective was to examine the effects of T/HS on -sulfated (3-OS) expression determine whether AT-heparan interactions necessary for properties. Methods Male Sprague Dawley rats underwent laparotomy, gut distension fixed-pressure (HS)...
To evaluate the influence of various distributions bone cement on clinical efficacy percutaneous kyphoplasty (PKP) in treating osteoporotic vertebrae compression fractures.A total 201 OVCF patients (30 males and 171 females) who received PKP treatment our hospital were enrolled this study. According to characteristic distribution, divided into 2 groups: group A ("H" shaped group), filling pattern vertebral body briquettes connected with / without bridge; B ("O" was a complete crumb any...
<h3>Importance</h3> Venous thromboembolism (VTE) affects 2% to 20% of recovering trauma patients, despite aggressive prophylaxis with enoxaparin. Antithrombin is a primary circulating anticoagulant and crucial component enoxaparin thromboprophylaxis. Approximately patients present antithrombin deficiency (antithrombin activity <80%). <h3>Objective</h3> To examine time-dependent changes in activity, responsiveness enoxaparin, as measured by anti–factor Xa (anti-FXa) levels, incidence VTE...
To explore the effect of resveratrol in premature senescence and reveal its anti-premature mechanisms through network pharmacology.In this study, H2O2-induced bone marrow mesenchymal stem cells (BMMSCs) model is applied. Cell counting kit-8 assay, β-galactosidase staining flow cytometry are conducted to detect proliferation, apoptosis BMMSCs. Bioinformatics analyses used screen validate molecular targets acting on senescence. Dual-luciferase reporter assay verify interaction between v-rel...
Dysregulated inflammation and coagulation are underlying mechanisms driving organ injury after trauma hemorrhagic shock. Heparan sulfates, cell surface glycosaminoglycans abundantly expressed on the endothelial surface, regulate a variety of cellular processes. Endothelial heparan sulfate containing rare 3-O-sulfate modification glucosamine residue is anticoagulant anti-inflammatory through high-affinity antithrombin binding sequestering circulating damage-associated molecular pattern...
OBJECTIVE Traumatic brain injury (TBI) and hemorrhage are responsible for the largest proportion of all trauma-related deaths. In polytrauma patients at risk TBI, diagnosis, prognosis, management TBI remain poorly characterized. The authors sought to characterize predictive capabilities glial fibrillary acidic protein (GFAP) ubiquitin C-terminal hydrolase L1 (UCH-L1) measurements in with hemorrhagic shock without concomitant TBI. METHODS performed a secondary analysis on serial blood samples...
OBJECTIVES Cold-stored low-titer whole blood (WB) is becoming increasingly used as the preferred product for initial hemorrhagic shock resuscitation. The purpose of this study was to identify whether current 21-day shelf life optimal duration storage WB, maintaining hemostatic efficacy. METHODS Five units fresh group O WB (non-leukoreduced) were acquired from our regional center. These stored at 4°C up 21 days per clinical guidelines in emergency department. Hemostatic parameters measured...
To compare the clinical efficacy and radioactivity of bridge-type zero-profile anchored spacer (ROI-C) interbody fusion cage anterior cervical discectomy with plating system (ACDF) for spondylotic myelopathy (CSM).This is a retrospective contrastive study. We recruited 35 patients who received ROI-C (ROI-C group) 34 ACDF (ACDF group), between January 2014 to 2019, at our treatment center. The group comprised 11 males 24 females mean age 61.59 ± 8.21 years (range, 51-71 years). 12 22 60.15...
BACKGROUND:The aim of this study was to compare the outcomes following anterior cervical discectomy and fusion with zero-profile anchored spacer-ROI-C-fixation (ROI-C) vs combined intervertebral cage (ACDF). MATERIAL AND METHODS:We retrospectively analyzed 87 patients who underwent operations between January 2015 2019, including 42 that ROI-C treatment (group A) 45 were treated by ACDF approach B). Operative duration, blood loss, dysphagia, Neck Disability Index scores (NDI), Japanese...
Glioblastoma (GBM) is one of the worst cancers with bad prognosis despite systemic chemotherapy and radiotherapy after surgery.In this study, 71 patients GBM were enrolled randomly assigned to two groups: Receiving concomitant adjuvant temozolomide (TMZ) (TMZ, standard therapy) surgery, or receiving local delivery nimustine (ACNU) rendezvousing oral TMZ (rendezvous therapy). In follow-up all progression-free survival (PFS), overall (OS), Karnofsky performance score (KPS) toxicities...
Severe trauma is accompanied by endothelial glycocalyx disruption, which drives coagulopathy, increasing transfusion requirements and death. This syndrome has been termed endotheliopathy of (EOT). Some have suggested EOT results from cellular damage apoptosis. Endothelial microvesicles (EMVs) represent damage. We hypothesized that associated with apoptosis resulting in an increase circulating EMVs.Prospective, observational study enrolling severely injured patients. Twelve patients EOT,...
The recognition of idiopathic membranous nephropathy (IMN) as an autoimmune disease has paved the way for use B-cell-depleting agents, such Rituximab (RTX), which is now a first-line drug treating IMN with proven safety and efficacy. Nevertheless, usage RTX treatment refractory remains controversial challenging.To evaluate efficacy new low-dose regimen patients IMN.A retrospective study was performed on that accepted (RTX, 200 mg, once month five months) in Xiyuan Hospital Chinese Academy...
Abstract Membranoproliferative glomerulonephritis (MPGN) is usually characterized by refractory nephrotic syndrome and associated with a poor prognosis. An older patient diagnosed MPGN had 20-year history of proteinuria clinical manifestations in the past 2 years. MPGN. Before patients received an 11-month traditional Chinese medicine (TCM) treatment, was treated prednisone, tacrolimus, mycophenolate mofetil, rituximab for 11 months. After 22 months, urine protein level decreased to <1...
Abstract The TRPM4 gene codes for a membrane ion channel subunit related to inflammation in the central nervous system. Recent investigation has identified an association between single nucleotide polymorphisms (SNPs) rs8104571 and rs150391806 increased intracranial (ICP) pressure following traumatic brain injury (TBI). We assessed influence of these genotypes on clinical outcomes ICP TBI patients. included 292 trauma patients with TBI. DNA extraction real-time PCR were used allele...
BACKGROUND: Glioblastoma is the most common and aggressive type of primary brain tumor. OBJECTIVE: The aim this study was to investigate efficacy safety intranasal granulocyte-macrophage colony stimulating factor (GM-CSF) administration combined with chemoradiotherapy in patients glioblastoma who underwent surgery. METHODS: Ninety-two were randomly divided into two groups: a control group (n= 46), received radiotherapy adjuvant local delivery nimustine hydrochloride (ACNU) systemic...