A5014361002- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Trauma and Emergency Care Studies
- Cerebrovascular and Carotid Artery Diseases
- Anatomy and Medical Technology
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Arrest and Resuscitation
- Surgical Simulation and Training
- Venous Thromboembolism Diagnosis and Management
- Platelet Disorders and Treatments
- Cardiovascular Health and Disease Prevention
- Hernia repair and management
- Congenital Heart Disease Studies
- Aortic Disease and Treatment Approaches
- Tissue Engineering and Regenerative Medicine
- Additive Manufacturing and 3D Printing Technologies
- Traumatic Brain Injury and Neurovascular Disturbances
- Abdominal Trauma and Injuries
- Acute Ischemic Stroke Management
- Aortic aneurysm repair treatments
- Cardiac Structural Anomalies and Repair
- Blood transfusion and management
- Mechanical Circulatory Support Devices
- Blood properties and coagulation
- Tracheal and airway disorders
- Kawasaki Disease and Coronary Complications
The University of Texas Health Science Center at Houston
2013-2024
University of Houston
2023
Anna Needs Neuroblastoma Answers
2020
Memorial Hospital
2019
Memorial Hermann
2014
National Transportation Safety Board
2012
Barclays (United Kingdom)
2012
Walt Disney (United States)
2012
National Aeronautics and Space Administration
2012
Spectral MD (United States)
2010
Thrombelastography (TEG) fibrinolysis shutdown after trauma is associated with increased mortality due to hypercoagulability-associated organ failure. However, a lack of mechanistic data has precluded the development novel interventions treat shutdown.To define pathophysiology TEG in severely injured, bleeding patients through secondary analysis PROPPR trial.Fibrinolysis was characterized subjects using admission lysis at 30 min (LY30) or plasmin-antiplasmin (PAP) levels. LY30 categories...
Abstract Clinical cellular therapeutics (CCTs) have shown preliminary efficacy in reducing inflammation after trauma, preserving cardiac function myocardial infarction, and improving functional recovery stroke. However, most clinically available cell lines express tissue factor (TF) which stimulates coagulation. We sought to define the degree of procoagulant activity CCTs as related TF expression. CCT samples from bone marrow, adipose, amniotic fluid, umbilical cord, multi-potent adult...
The purpose of this investigation is to use a computational model compare synchronized valveless pulsatile left ventricular assist device with continuous flow devices at the same level flow, and verify in vivo porcine data. A dynamic system human cardiovascular was developed simulate support healthy or failing native heart from synchronous dual-piston positive displacement pump. These results were compared measurements made during experiments. Results simulation counterpart show that pump...
The objectives of this study were to compare thromboelastography platelet mapping (TEG PM) with impedance aggregometry (Multiplate, MP) in a single trauma population and relate their results clinically.Platelet function as measured by demonstrates significant reductions that persist for days following traumatic injury. However, no compares these devices the correlation between them is not known.In level 1 patients, TEG PM MP conducted at initial presentation emergency department....
Abstract Clinical trials in trauma populations are exploring the use of clinical cellular therapeutics (CCTs) like human mesenchymal stromal cells (MSC) and mononuclear (MNC). Recent studies demonstrate a procoagulant effect these CCTs related to their expression tissue factor (TF). We sought examine this relationship blood from severely injured patients identify methods reverse effect. Human MSCs bone marrow, adipose, amniotic tissues freshly isolated marrow MNC samples were tested. TF...
OBJECTIVES Cold-stored low-titer whole blood (WB) is becoming increasingly used as the preferred product for initial hemorrhagic shock resuscitation. The purpose of this study was to identify whether current 21-day shelf life optimal duration storage WB, maintaining hemostatic efficacy. METHODS Five units fresh group O WB (non-leukoreduced) were acquired from our regional center. These stored at 4°C up 21 days per clinical guidelines in emergency department. Hemostatic parameters measured...
This article describes the stroke volume selection and operational design for toroidal ventricular assist device (TORVAD), a synchronous, positive-displacement (VAD). A lumped parameter model was used to simulate hemodynamics with TORVAD compared those under continuous-flow VAD support. Results from simulation demonstrated that 30 ml ejecting an early diastolic counterpulse provides comparable systemic support HeartMate II (HMII) (cardiac output 5.7 L/min up 3.1 in simulated heart failure)....
The use of the resuscitative endovascular balloon occlusion aorta (REBOA) device is expanding in adult trauma. Reports its pediatric patients have been published, but no guidelines currently exist nor has it Food and Drug Administration approved pediatrics. This project develops a model to determine appropriate inflation volumes guide potential use. Artificial aortas were three-dimensional (3D) printed using synthetic polymers. Segments created based on aortic diameters from 289 trauma...
Platelet contraction provides a minimally invasive source for physiologic information. In this article, we describe device that directly measures the kinetics of platelet contraction. Whole blood is injected between acrylic plates and an adherent clot forms. The bottom plate fixed, top attached to wire cantilever. drives deflection cantilever which captured by camera. Force generated with time derived using beam equations. derivations were verified microelectromechanical (MEMS) force sensor....
An extracranial carotid artery aneurysm (ECAA) is a rare pathology comprising <1% of all arterial aneurysms. The etiology includes trauma, previous surgery, radiation, and infection. Treatment ECAAs has evolved from open repair to endovascular with stenting. Reports describe the transfemoral approach; however, little more than case reports are available describing transcarotid approach for ECAAs. In this study, we cohort patients who safely underwent ECAAs.We performed retrospective medical...
Objective Several studies suggest that females have higher perioperative adverse events and decreased benefit from carotid artery revascularization with transfemoral stenting endarterectomy (CEA) compared to males. However, there are limited data of sex-based outcomes for transcarotid (TCAR). Methods A retrospective review prospectively maintained system-wide TCAR databases was performed between December 2015-January 2022. Patients who underwent were stratified based on sex. Relevant...