A5008203229- Respiratory Support and Mechanisms
- Mesenchymal stem cell research
- Abdominal Surgery and Complications
- Tissue Engineering and Regenerative Medicine
- Muscle and Compartmental Disorders
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Additive Manufacturing and 3D Printing Technologies
- Traumatic Brain Injury and Neurovascular Disturbances
- Hemodynamic Monitoring and Therapy
- Surgical Simulation and Training
- Congenital Diaphragmatic Hernia Studies
- Electrospun Nanofibers in Biomedical Applications
- Anatomy and Medical Technology
- Hernia repair and management
- COVID-19 and Mental Health
- Additive Manufacturing Materials and Processes
- Cancer Cells and Metastasis
- SARS-CoV-2 detection and testing
- Clinical Nutrition and Gastroenterology
- Blood properties and coagulation
- 3D Printing in Biomedical Research
- Venous Thromboembolism Diagnosis and Management
- Electrical and Bioimpedance Tomography
- Advanced Sensor and Energy Harvesting Materials
University of Maryland, Baltimore
2022-2025
University of Maryland, College Park
2019-2025
The University of Texas Health Science Center at Houston
2008-2021
College Station Medical Center
2010
University of Houston
2010
Texas A&M University
2009
Abstract Background Patients with traumatic brain injury ( TBI ) often suffer from gastrointestinal dysfunction including intolerance to enteral feedings. However, it is unclear how affects small intestinal contractile activity. The purpose of this study was determine if smooth muscle function. Methods Sprague–Dawley rats were subjected controlled cortical impact ). Sham animals underwent a similar surgery but no SHAM Animals sacrificed 1, 3, and 7 days after tissue collected for measurement...
Abstract We previously demonstrated that the intravenous delivery of multipotent adult progenitor cells (MAPCs) after traumatic brain injury (TBI) in rodents provides neuroprotection by preserving blood-brain barrier and systemically attenuating inflammation acute time frame following cell treatment; however, long-term behavioral anti-inflammatory effects MAPC administration TBI have yet to be explored. hypothesized injection MAPCs attenuates inflammatory response (as measured microglial...
Mesenchymal stromal cells (MSCs) are believed to mobilize from the bone marrow in response inflammation and injury, yet effects of egress into vasculature on MSC function largely unknown. Here we show that wall shear stress (WSS) typical fluid frictional forces present vascular lumen stimulates antioxidant anti-inflammatory mediators, as well chemokines capable immune cell recruitment. WSS specifically promotes signaling through NFκB-COX2-prostaglandin E
Bone cement implantation syndrome (BCIS) is a life-threatening risk of cemented stems. There are limited methods to prevent BCIS and few published studies. A survey the Musculoskeletal Tumor Society (MSTS) surgeons was conducted evaluate their experiences with BCIS. novel stem designed reduce intramedullary pressure during insertion evaluated. distributed MSTS members, data collected. The featured hollow longitudinal channel, an entry hole at tip, egress collar for flow from canal insertion....
Current mesenchymal stromal cell (MSC) delivery methods require infusion/implantation through needles and/or catheters. Little investigation into the effect of via catheter injection has been completed. We hypothesize that rat and human MSCs various clinically relevant-sized catheters flow rates will not affect viability, characterization, or function.Both were injected 20-, 25-, 30-gauge needles, as well an SL-10 microcatheter at 60, 120, 240, 500 mL/h. MSC viability apoptotic fraction was...
Background: Current abdominal compartment syndrome (ACS) models rely on intraperitoneal instillation of fluid, air, and other space-occupying substances. Although this allows for the study effects increased pressure, it poorly mimics its pathogenesis. We have developed first reported large animal model ACS incorporating hemorrhagic shock/resuscitation. Methods: Hemorrhagic shock was induced maintained (1 hour) in 12 Yorkshire swine by bleeding to a mean arterial pressure (MAP) 50 mm Hg. The...
Tissue engineering is an emerging strategy for repairing damaged tissues or organs. The current study explored using decellularized rat diaphragm scaffolds combined with human amniotic fluid-derived multipotent stromal cells (hAFMSC) to provide a scaffold, stem cell construct that would allow structural barrier function during tissue ingrowth/regeneration. We created innovative infusion system allowed hAFMSC embed into and then implanted the composite rats surgically left-sided diaphragmatic...
In the present paper, we report development of electrospun PVDF-TrFE (polyvinyledenedifluoride-tetrafluoroethylene) nanofibers based sensor. order to boost sensitivity sensors, highly aligned were directly deposited on a custom patterned flexible substrate. The complete process from optimization electrospinning parameters fabrication sensors and testing has been described. Preliminary results showed that devices capable generating 300mV signal with 0.45s recovery time manual mechanical deformation.
Platelet contraction provides a minimally invasive source for physiologic information. In this article, we describe device that directly measures the kinetics of platelet contraction. Whole blood is injected between acrylic plates and an adherent clot forms. The bottom plate fixed, top attached to wire cantilever. drives deflection cantilever which captured by camera. Force generated with time derived using beam equations. derivations were verified microelectromechanical (MEMS) force sensor....
This article presents a novel mechatronic setup intended for providing respiratory support to patients suffering from pulmonary failure. The relies upon the circulation of an oxygenated perfluorocarbon (PFC) through abdominal cavity. Such provides potential pathway transport oxygen bloodstream. However, viability this technology <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math...