A5057104126- Traumatic Brain Injury and Neurovascular Disturbances
- Mesenchymal stem cell research
- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cancer Cells and Metastasis
- Anatomy and Medical Technology
- Barrier Structure and Function Studies
- Ultrasound in Clinical Applications
- Bone Tissue Engineering Materials
- Neonatal and fetal brain pathology
- Surgical Simulation and Training
- CAR-T cell therapy research
- Periodontal Regeneration and Treatments
- Digital Imaging in Medicine
- Cell Adhesion Molecules Research
- Clinical practice guidelines implementation
- Aortic aneurysm repair treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Connexins and lens biology
- Intensive Care Unit Cognitive Disorders
- 3D Printing in Biomedical Research
- Extracellular vesicles in disease
- Hematopoietic Stem Cell Transplantation
- Venous Thromboembolism Diagnosis and Management
The University of Texas Health Science Center at Houston
2017-2024
Memorial Hospital
2019
The Blood-Brain Barrier (BBB) is a highly-selective physiologic barrier responsible for maintaining cerebral homeostasis. Innovative in vitro models of the BBB are needed to provide useful insights into function with CNS disorders like traumatic brain injury (TBI). TBI multidimensional and highly complex pathophysiological condition that requires intrinsic elucidate its mechanisms. Current either lack fluidic shear stress, or neglect hemodynamic parameters important recapitulating human vivo...
Mesenchymal stromal cells (MSC) undergo functional maturation upon their migration from bone marrow and introduction to a site of injury. This inflammatory licensing leads heightened immune regulation via cell-to-cell interaction the secretion immunomodulatory molecules, such as anti-inflammatory mediators antioxidants. Pro-inflammatory cytokines are recognized catalyst licensing; however, biomechanical forces, fluid shear stress, second, distinct class stimuli that incite maturation. Here...
Abstract The only available option to treat radiation-induced hematopoietic syndrome is allogeneic cell transplantation, a therapy unavailable many patients undergoing treatment for malignancy, which would also be infeasible in radiological disaster. Stromal cells serve as critical components of the stem niche and are thought protect under stress. Prior studies that have transplanted mesenchymal stromal (MSCs) without co-administration graft shown underwhelming rescue endogenous...
The use of the resuscitative endovascular balloon occlusion aorta (REBOA) device is expanding in adult trauma. Reports its pediatric patients have been published, but no guidelines currently exist nor has it Food and Drug Administration approved pediatrics. This project develops a model to determine appropriate inflation volumes guide potential use. Artificial aortas were three-dimensional (3D) printed using synthetic polymers. Segments created based on aortic diameters from 289 trauma...
Platelet contraction provides a minimally invasive source for physiologic information. In this article, we describe device that directly measures the kinetics of platelet contraction. Whole blood is injected between acrylic plates and an adherent clot forms. The bottom plate fixed, top attached to wire cantilever. drives deflection cantilever which captured by camera. Force generated with time derived using beam equations. derivations were verified microelectromechanical (MEMS) force sensor....
Abstract The immune system plays critical roles in promoting tissue repair during recovery from neurotrauma but is also responsible for unchecked inflammation that causes neuronal cell death, systemic stress, and lethal immunodepression. Understanding the response to an urgent priority, yet current models of traumatic brain injury (TBI) inadequately recapitulate human response. Here, we report first description a humanized model TBI show places significant stress on bone marrow....
An amendment to this paper has been published and can be accessed via a link at the top of paper.
Traumatic brain injury (TBI) results in activated microglia. Activated microglia can be measured vivo by using positron emission topography (PET) ligand peripheral benzodiazepine receptor standardized uptake values (PBR28suv). Cell based therapies have utilized autologous bone marrow mononuclear cells (BMMNCs) to attenuate after TBI. This study aims utilize PBR28suv assess the efficacy of BMMNCs therapy Seventy-two hours CCI injury, were harvested from tibia and injected via tail-vein at 74...
The next-generation of mesenchymal stromal cell (MSC) therapies aim to enhance efficacy via in vitro licensing. Various stimuli initiate immune regulation and the secretion immunomodulatory molecules, such as anti-inflammatory mediators antioxidants, prior administration. Pro-inflammatory cytokines are a recognized catalyst inflammatory licensing; however, biomechanical forces, fluid shear stress, second, distinct class that incite functional maturation. Here we show mechanotransduction,...
Abstract The Blood-Brain Barrier (BBB) is a highly-selective physiologic barrier responsible for maintaining cerebral homeostasis. Innovative in vitro models of the BBB are needed to provide useful insights into function with CNS disorders like TBI. Current either lack fluidic shear stress, or neglect hemodynamic parameters important recapitulating human vivo phenotype. To address these limitations field, we developed fluid dynamic novel platform which closely mimics parameters. validate our...