A5101424642- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
- Inflammasome and immune disorders
- Supramolecular Self-Assembly in Materials
- Advanced biosensing and bioanalysis techniques
- Protease and Inhibitor Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Virus-based gene therapy research
- Cell Adhesion Molecules Research
- Spectroscopy and Chemometric Analyses
- Bone Tissue Engineering Materials
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Computer Graphics and Visualization Techniques
- Inflammation biomarkers and pathways
- RNA and protein synthesis mechanisms
- Crystallization and Solubility Studies
- Immune cells in cancer
- biodegradable polymer synthesis and properties
- Transgenic Plants and Applications
- Remote Sensing and Land Use
- Fluid Dynamics and Heat Transfer
Army Medical University
2013-2023
Ruijin Hospital
2022-2023
Shanghai Jiao Tong University
2023
University of Science and Technology Beijing
2022
Anhui Medical University
2022
Shangqiu First People's Hospital
2015
Chongqing University
2015
Atherosclerosis is a leading cause of vascular diseases worldwide. Whereas antioxidative therapy has been considered promising for the treatment atherosclerosis in view critical role reactive oxygen species (ROS) pathogenesis atherosclerosis, currently available antioxidants showed considerably limited clinical outcomes. Herein, we hypothesize that broad-spectrum ROS-scavenging nanoparticle can serve as an effective taking advantage its stress activity and targeting effects. As proof...
Targeting of nanoparticles to distant diseased sites after oral delivery remains highly challenging due the existence many biological barriers in gastrointestinal tract. Here we report targeted diverse multiple disease models, via a "Trojan horse" strategy based on bioinspired yeast capsule (YC). Diverse charged nanoprobes including quantum dots (QDs), iron oxide (IONPs), and assembled organic fluorescent can be effectively loaded into YC through electrostatic force-driven spontaneous...
To develop reactive oxygen species (ROS)-responsive anti-inflammatory materials and establish their structure–property correlations, a series of H2O2-eliminating (OxbCDs) were designed synthesized by conjugating different phenylboronic acid pinacol ester (PBAP) groups onto biocompatible scaffold compound β-cyclodextrin via varied linker groups. Both the H2O2-triggered hydrolysis profiles capacities these dependent on chemical structure PBAP moieties. Together with elucidation mechanisms, we...
Abstract Inflammation is a common cause of many acute and chronic inflammatory diseases. A major limitation existing anti‐inflammatory therapeutics that they cannot simultaneously regulate pro‐inflammatory cytokine production, oxidative stress, recruitment neutrophils macrophages. To overcome this limitation, nanoparticles (NPs) with multiple pharmacological activities are synthesized, using chemically modified cyclic oligosaccharide. The manufacture type bioactive, saccharide material‐based...
Abstract Atherosclerosis remains the leading cause of a broad spectrum deadliest cardiovascular diseases. MicroRNA‐33 is new therapeutic target for atherosclerosis due to its diverse functions. However, it great challenge in clinical translation nucleic acid‐based microRNA‐targeting therapeutics. Considering lesional acidosis, herein cyclodextrin‐derived pH‐responsive and integrin‐targeting nanoparticles containing an antisense oligonucleotide against microRNA‐33 (anti‐miR33) are engineered...
Colitis-associated colon cancer (CAC) is a widely recognized cancer, while treatment with the existing chemotherapeutic drugs affords limited clinical benefits. Herein we proposed site-specific, combination nanotherapy strategy for targeted of CAC by oral route. Methods: A reactive oxygen species (ROS)-responsive and hydrogen peroxide-eliminating material OCD was synthesized, which further produced into functional nanoparticle (OCD NP). The antioxidative stress anti-inflammatory effects NP...
Abstract Cardiovascular diseases (CVDs) are still the first cause of death worldwide. Conventional small molecular diagnostic and therapeutic agents generally show limited in vivo detection sensitivity efficacies, due to their non‐targeting distribution and/or low accumulation at diseased sites. New strategies required better address unmet need for management CVDs. Bioresponsive nanoplatforms with excellent triggerable release profiles desirable targeting capability have demonstrated...
Liver injury can result in different hepatic diseases such as fatty liver, liver fibrosis, hepatitis, and failure, which are mainly responsible for global mortality morbidity. Early diagnosis is critical the treatment of diseases. Herein we report luminescence imaging neutrophil-mediated acute injury, including alcoholic (ALI) failure (ALF). To this purpose, a biodegradable luminescent material was developed by chemical functionalization cyclic oligosaccharide, be produced into nanoprobes...
Background: Atherosclerosis is a fundamental pathological process responded to some serious cardiovascular events. Although the cholesterol-lowering drugs are widely prescribed for atherosclerosis therapy, it still leading cause of death in developed world. Here we measured effects compound K formation and investigated probably mechanisms anti-antherosclerosis roles K. Methods: We treated atherosclerotic model animals (apoE−/− mice on western diet) with size lesions, inflammatory cytokine...
Uncontrolled and persistent inflammation is closely related to numerous acute chronic diseases. However, effective targeting delivery systems remain be developed for precision therapy of inflammatory Herein we report a novel strategy engineering inflammation-accumulation nanoparticles via phenolic functionalization. Different phenol-functionalized were first developed, which can undergo in situ aggregation upon triggering by the inflammatory/oxidative microenvironment. Phenolic...
We report a host–guest strategy that can simultaneously realize assembly and therapeutic loading, affording superstructures with tunable size multiple morphologies.
Paraneoplastic amyotrophic lateral sclerosis (ALS) is a rare and special type of ALS. The pathogenesis, clinical presentation, treatment prognosis remain poorly understood. We herein presented three cases paraneoplastic In case 1, we first reported an ALS patient with the positive serum antibodies against both Sry-like high mobility group box 1 (SOX1) glutamic acid decarboxylase 65 (GAD65). However, immunotherapy did not improve his neurological symptoms. also two patients renal clear cell...