A5071851424- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Drug Transport and Resistance Mechanisms
- Supramolecular Self-Assembly in Materials
- Immunotherapy and Immune Responses
- Inflammatory Bowel Disease
- RNA Interference and Gene Delivery
- Advanced Drug Delivery Systems
- Supramolecular Chemistry and Complexes
- Advanced Nanomaterials in Catalysis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Advanced Materials and Mechanics
- Plant Pathogenic Bacteria Studies
- Glycosylation and Glycoproteins Research
- Telomeres, Telomerase, and Senescence
- Plant Virus Research Studies
- Plant-Microbe Interactions and Immunity
- Calcium Carbonate Crystallization and Inhibition
- Genetics, Aging, and Longevity in Model Organisms
- Aerogels and thermal insulation
- Advanced Sensor and Energy Harvesting Materials
- Surfactants and Colloidal Systems
- Advanced battery technologies research
- Nonlinear Differential Equations Analysis
Ningbo University
2025
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2021-2024
University of Electronic Science and Technology of China
2021-2024
Dazhou Central Hospital
2024
Fujian Agriculture and Forestry University
2021-2023
Army Medical University
2015-2022
Northwestern Polytechnical University
2021
Chongqing University
2015-2018
The incidence and prevalence of inflammatory bowel disease (IBD) increases steadily worldwide. There is an urgent need for effective safe IBD therapies. Accelerated resolution inflammation a new strategy the management diseases. For treatment, herein smart nanotherapy (i.e. oxidation-responsive nanoparticles containing proresolving annexin A1-mimetic peptide Ac2-26, defined as AON) developed, which can release packaged in response to highly expressed reactive oxygen species (ROS) at diseased...
To develop reactive oxygen species (ROS)-responsive anti-inflammatory materials and establish their structure–property correlations, a series of H2O2-eliminating (OxbCDs) were designed synthesized by conjugating different phenylboronic acid pinacol ester (PBAP) groups onto biocompatible scaffold compound β-cyclodextrin via varied linker groups. Both the H2O2-triggered hydrolysis profiles capacities these dependent on chemical structure PBAP moieties. Together with elucidation mechanisms, we...
Colitis-associated colon cancer (CAC) is a widely recognized cancer, while treatment with the existing chemotherapeutic drugs affords limited clinical benefits. Herein we proposed site-specific, combination nanotherapy strategy for targeted of CAC by oral route. Methods: A reactive oxygen species (ROS)-responsive and hydrogen peroxide-eliminating material OCD was synthesized, which further produced into functional nanoparticle (OCD NP). The antioxidative stress anti-inflammatory effects NP...
Abstract High energy storage performances in multilayer nanocomposites are crucial for the advancement of modern electronic and power systems. However, large dielectric contrast between adjacent layers leads to an uneven electric field distribution, which hampers potential further increasing their performances. Herein, five-layer gradient-structured were designed fabricated based on previous sandwich framework by introducing transition outmost insulation layer inner polarization layer....
Aqueous zinc ion batteries are gaining prominent attention due to their potentially high safety, low cost, and volumetric capacity. However, disparities still exist in specific capacity kinetic performances within the electrode materials of batteries. Herein, electrochemical properties layered vanadium oxide (VOH) nanorods adopting Sr2+ La3+ as pillars were investigated systematically. It was shown that (1La,1Sr)-VOH possessed a around 345.8 mAh g–1 at current density 1 A g–1, which...
Uncontrolled and persistent inflammation is closely related to numerous acute chronic diseases. However, effective targeting delivery systems remain be developed for precision therapy of inflammatory Herein we report a novel strategy engineering inflammation-accumulation nanoparticles via phenolic functionalization. Different phenol-functionalized were first developed, which can undergo in situ aggregation upon triggering by the inflammatory/oxidative microenvironment. Phenolic...
Affinity nanoparticles formed by host–guest interaction-mediated self-assembly of cyclodextrin (CD)-containing copolymers can function as effective nanoplatforms for drug delivery.
We report a host–guest strategy that can simultaneously realize assembly and therapeutic loading, affording superstructures with tunable size multiple morphologies.
Drug-induced hepatitis (DIH), which seriously interferes with disease treatment, is one of the most common reasons for termination new drugs during preclinical studies or post-marketing surveillance.Although antioxidants and anti-inflammatory agents are promising, their nonspecific distribution insolubility limit application.Therefore, precise drug release at site an important way to alleviate DIH avoid side effects.Methods: A gripper-like hydrophilic cyclic phenylboronic acid (cPBA) was...
Aromatized thioketal (ATK) linked the immunoregulatory molecule (budesonide, Bud) and cytotoxic (gemcitabine, Gem) to construct a ROS-activated Janus-prodrug, termed as BAG. Benefiting from hydrogen bonding, π-π stacking, other intermolecular interactions, BAG could self-assemble into nanoaggregates (BAG NA) with well-defined spherical shape uniform size distribution. Compared carrier-based drug delivery system, NA have ultrahigh loading content ROS concentration-dependent release....