A5100655932- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- Extracellular vesicles in disease
- Nanoparticle-Based Drug Delivery
- Inflammasome and immune disorders
- Radiomics and Machine Learning in Medical Imaging
- Inhalation and Respiratory Drug Delivery
- Flavonoids in Medical Research
- Advanced Nanomaterials in Catalysis
- Atherosclerosis and Cardiovascular Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Sirtuins and Resveratrol in Medicine
- Medical Imaging and Analysis
- Cancer-related molecular mechanisms research
- Heme Oxygenase-1 and Carbon Monoxide
- Photodynamic Therapy Research Studies
- Autophagy in Disease and Therapy
- Acute Myeloid Leukemia Research
- AI in cancer detection
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Protein Degradation and Inhibitors
- Pickering emulsions and particle stabilization
- Natural product bioactivities and synthesis
- Paraquat toxicity studies and treatments
Army Medical University
2016-2025
Lanzhou University
2019-2025
Lanzhou University Second Hospital
2019-2025
Fuzhou University
2023-2025
Anhui Medical University
2020-2025
Gansu Provincial Maternal and Child Health Hospital
2024
Weifang Medical University
2024
Shanxi Medical University
2023
First Affiliated Hospital of Anhui Medical University
2023
Guang’anmen Hospital
2023
Atherosclerosis is a leading cause of vascular diseases worldwide. Whereas antioxidative therapy has been considered promising for the treatment atherosclerosis in view critical role reactive oxygen species (ROS) pathogenesis atherosclerosis, currently available antioxidants showed considerably limited clinical outcomes. Herein, we hypothesize that broad-spectrum ROS-scavenging nanoparticle can serve as an effective taking advantage its stress activity and targeting effects. As proof...
Stroke is a primary cause of death and disability worldwide, while effective safe drugs remain to be developed for its clinical treatment. Herein, we report bioactive nanoparticle-derived multifunctional nanotherapies ischemic stroke, which are engineered from pharmacologically active oligosaccharide material (termed as TPCD) prepared by covalently conjugating radical-scavenging compound (Tempol) hydrogen-peroxide-eliminating moiety phenylboronic acid pinacol ester (PBAP) on β-cyclodextrin....
Despite the great potential of numerous antioxidants for pharmacotherapy diseases associated with inflammation and oxidative stress, many challenges remain their clinical translation. Herein, a superoxidase dismutase/catalase-mimetic material based on Tempol phenylboronic acid pinacol ester simultaneously conjugated β-cyclodextrin (abbreviated as TPCD), which is capable eliminating broad spectrum reactive oxygen species (ROS), reported. TPCD can be easily synthesized by sequentially...
Abstract Inflammation is a common cause of many acute and chronic inflammatory diseases. A major limitation existing anti‐inflammatory therapeutics that they cannot simultaneously regulate pro‐inflammatory cytokine production, oxidative stress, recruitment neutrophils macrophages. To overcome this limitation, nanoparticles (NPs) with multiple pharmacological activities are synthesized, using chemically modified cyclic oligosaccharide. The manufacture type bioactive, saccharide material‐based...
Abstract Atherosclerosis remains the leading cause of a broad spectrum deadliest cardiovascular diseases. MicroRNA‐33 is new therapeutic target for atherosclerosis due to its diverse functions. However, it great challenge in clinical translation nucleic acid‐based microRNA‐targeting therapeutics. Considering lesional acidosis, herein cyclodextrin‐derived pH‐responsive and integrin‐targeting nanoparticles containing an antisense oligonucleotide against microRNA‐33 (anti‐miR33) are engineered...
Postoperative epidural adhesion remains a clinically challenging problem in spine surgery. Currently there are no effective and safe antifibrotic antiadhesion biomaterials that have been specifically developed for this complication clinical practice. Herein we designed engineered an advanced hydrogel with multiple functionalities, including temperature-responsive gelation, self-healing, tissue adhesiveness, antioxidation, anti-inflammation, antifibrosis. This multifunctional supramolecular...
Abstract Effective therapies capable of simultaneously inhibiting inflammation and promoting bone healing remain to be developed for inflammatory disease. Stem cell hold great promise a variety diseases, but their translation is hampered by low survival, rapid clearance, limited functional integration transplanted stem cells in target tissues. Herein, multifunctional hydrogel‐based niche engineering strategy reported the treatment loss. By rationally integrating different modules, an...
High potency and safe therapies are still required for ischemic stroke, which is a leading cause of global death disability. Herein, reactive oxygen species (ROS)-responsive, transformable, triple-targeting dl-3-n-butylphthalide (NBP) nanotherapy was developed stroke. To this end, ROS-responsive nanovehicle (OCN) first constructed using cyclodextrin-derived material, showed considerably enhanced cellular uptake in brain endothelial cells due to notably reduced particle size, morphological...
Abstract Background Sanguinarine chloride (S.C) is a benzophenanthrine alkaloid derived from the root of sanguinaria canadensis and other poppy-fumaria species. Studies have reported that S.C exhibits antioxidant, anti-inflammatory, proapoptotic, growth inhibitory effects, which contribute to its anti-cancer properties. Recent studies suggested antitumor effect through inducing ferroptosis in some cancers. Nevertheless, precise mechanism underlying regulation by remains poorly understood....
Accidental or suicidal ingestion of the world's most widely used herbicide, paraquat (PQ), may result in rapid multi-organ failure with a 60% fatality rate due to absence an effective detoxification solution. Effective, specific antidotes PQ poisoning have been highly desired.
Abstract Background Infectious diseases caused by multidrug-resistant (MDR) bacteria, especially MDR Gram-negative strains, have become a global public health challenge. Multifunctional nanomaterials for controlling bacterial infections via eradication of planktonic bacteria and their biofilms are great interest. Results In this study, we developed multifunctional platform (TG-NO-B) with single NIR laser-triggered PTT NO release synergistic therapy against biofilms. When located at the...
Heat flux density is an important parameter for evaluating the high-temperature performance of turbine blades. Accurate heat data play a significant role in design and manufacture blades their heat-dissipation performance. Current studies have shown that thin-film sensors (TFHFSs) are suitable signal monitoring complex blade surfaces. However, TFHFSs multilayer structure, which difficult to achieve using traditional physical vapor deposition (PVD). In this article, we propose approach...
Significant progress has been made in the development of potential therapies for diseases associated with inflammation and oxidative stress. Nevertheless, availability effective clinical treatments remains limited. Herein, we introduce a novel silk-based bioactive material, TPSF, developed by sequentially conjugating Tempol phenylboronic acid pinacol ester to silk fibroin. This innovative reactive oxygen species (ROS) scavenging material not only effectively eliminates free radicals hydrogen...
Prostate cancer is the most common and remains a leading cause of cancer-related deaths among men worldwide. Androgen deprivation therapy continues to be cornerstone treatment for prostate cancer. However, efficacy this treatments often limited, emergence drug resistance tumor recurrence. TAK-901, an inhibitor Aurora kinase B, has been shown inhibit growth both in vitro vivo models. To date, effect TAK-901 on underlying mechanism remain unknown. In study, we found that could proliferation,...
A series of potent indol-3-yl-tetramethylcyclopropyl ketones have been prepared as CB 2 cannabinoid receptor ligands. Two unsubstituted indoles ( 5, 32) were the starting points for an investigation effect indole ring substitutions on and 1 binding affinities activity in a vitro functional assay. Indole had varying effects binding, but generally detrimental to agonist activity. Substitution did lead improved 2/CB selectivity some cases (i.e., 7- 9, 15- 20). All with morpholino-ethyl side...
Succinylcholine (Sch) is the only depolarizing neuromuscular blocking agent widely used for rapid sequence induction in emergency rooms. Unfortunately, a variety of (sometimes lethal) adverse effects, such as hyperkalemia and cardiac arrest, are associated with its use, currently there no specific antidotes to reverse Sch or treat these side-effects.
Abstract There are still great challenges in promoting bone defect repair via regeneration strategies. In view of delayed healing due to local inflammation, herein, pathogenesis‐guided engineering multi‐bioactive hydrogel therapy is proposed for regeneration, by simultaneously improving the osteoimmune environment and enhancing osteogenic differentiation stem cells. After discovering pivotal role persistent inflammation loss pathogenesis periodontitis transcriptomics, a nanotherapy based on...