A5066075224- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Venous Thromboembolism Diagnosis and Management
- Extraction and Separation Processes
- Membrane-based Ion Separation Techniques
- MicroRNA in disease regulation
- Hydrogels: synthesis, properties, applications
- Membrane Separation and Gas Transport
- Lymphoma Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Medical and Biological Ozone Research
- Spaceflight effects on biology
- Neurological Disease Mechanisms and Treatments
- Biological and pharmacological studies of plants
- High Altitude and Hypoxia
Guiyang Medical University
2022-2025
Hunan University of Science and Technology
2023
Lanzhou University
2013-2019
Immune infiltration of tumors is closely associated with clinical outcome in renal cell carcinoma ( RCC ). Tumor‐infiltrating immune cells TIIC s) regulate cancer progression and are appealing therapeutic targets. The purpose this study was to determine the composition s further reveal independent prognostic values s. CIBERSORT , an established algorithm, applied estimate proportions 22 types based on gene expression profiles 891 tumors. Cox regression used evaluate association checkpoint...
Gastrodia elata Bl. has a long edible history and is considered an important functional food raw material. Gastrodin (GAS) one of the main substances in G. BI. can be used as health care product for elderly to enhance resistance delay aging. This study investigated ameliorative effect mechanism GAS on cognitive dysfunction vascular dementia (VaD) rats, which provides theoretical basis development utilization food. The water maze test shows that improves learning memory impairment VaD rats....
Abstract Background Sanguinarine chloride (S.C) is a benzophenanthrine alkaloid derived from the root of sanguinaria canadensis and other poppy-fumaria species. Studies have reported that S.C exhibits antioxidant, anti-inflammatory, proapoptotic, growth inhibitory effects, which contribute to its anti-cancer properties. Recent studies suggested antitumor effect through inducing ferroptosis in some cancers. Nevertheless, precise mechanism underlying regulation by remains poorly understood....
Alzheimer's disease (AD) is a chronic neurodegenerative disease, and its underlying genes treatments are unclear. Abnormalities in copper metabolism can prevent the clearance of β-amyloid peptides promote progression AD pathogenesis. Therefore, present study used bioinformatics approach to perform an integrated analysis hub gene based on cuproptosis that influence diagnosis treatment AD. The expression profiles were obtained from Gene Expression Omnibus database, including non-demented (ND)...
Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that predominantly affects elderly individuals across the globe. While genetic, environmental, and lifestyle factors are known to influence onset of AD, underlying mechanisms remain unclear. Objective To elucidate intricate interplay between metabolites immune cell activation in ethology determine their collective impact on AD risk. Methods We conducted comprehensive analysis genome-wide association studies data...
Background Deep Vein Thrombosis (DVT) represents a significant complication following orthopedic injuries, particularly patellar fractures. Despite the prevalence, comprehensive studies assessing incidence rates and identifying specific risk factors in fracture patients are limited. Methods This retrospective analysis reviewed electronic medical records from 3311 treated for fractures at two tertiary hospitals between November 2013 January 2023. The study focused on patient demographics,...
Several animal polysaccharides, e.g. heparin, are industrially produced for clinical applications. Isolation of these molecules involves multi-step purification process including polycationic adsorbents adsorption and the removal macromolecular impurities, protein, causing time-consuming environmental pollution. In this study, a novel quaternized chitosan@PVDF/SiO2 (QCCS@PS) membrane was fabricated selective separation heparin while simultaneously rejecting protein through an efficient...
Background: The pathophysiology of Alzheimer’s disease (AD) involves the interplay three different processes: pyroptosis, apoptosis, and necroptosis. Objective: To explore role PANoptosis, a novel pro-inflammatory programmed cell death pathway, in AD patients. Methods: We performed consensus clustering analysis to identify distinct transcriptional profiles samples using R package “ConsensusClusterPlus”. PANoptosis key genes were obtained by crossing WGCNA brown module differentially...
Background Alzheimer's disease (AD) is a leading cause of dementia, characterized by the accumulation amyloid-beta (Aβ) and hyperphosphorylated tau proteins, to neuroinflammation neuronal damage. The role immune system in AD pathogenesis increasingly recognized, prompting an exploration causal relationship between cells using Mendelian randomization (MR) approaches. Methods Utilizing genome-wide association study (GWAS) data from European cohorts, we conducted MR investigate links cell...
Abstract Background: The pathophysiology of Alzheimer's disease (AD) involves the interplay three different processes: pyroptosis, apoptosis, and necroptosis. However, role PANoptosis, a novel pro-inflammatory programmed cell death pathway, in AD remains unexplored. Result: Our study utilized tissue expression profile data from patients to construct distinct PANoptosis patterns, each with unique molecular clinical characteristics. We have created risk scoring system called PANscore, which...