A5103216190- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Cancer Cells and Metastasis
- Chemokine receptors and signaling
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Immunotherapy and Immune Responses
- Animal Genetics and Reproduction
- Sperm and Testicular Function
- Thermoregulation and physiological responses
- Birth, Development, and Health
- Oral microbiology and periodontitis research
- Histone Deacetylase Inhibitors Research
- Radiation Dose and Imaging
- Inflammatory Biomarkers in Disease Prognosis
- Exercise and Physiological Responses
- Bone health and treatments
- Superconducting and THz Device Technology
- Water Systems and Optimization
- Oral Health Pathology and Treatment
- Biomarkers in Disease Mechanisms
- Genetic and phenotypic traits in livestock
Baylor College of Medicine
2023-2025
The University of Texas at San Antonio
2025
Children's Cancer Center
2024-2025
Jilin Agricultural University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Wuhan University
2024
Peking Union Medical College Hospital
2023-2024
Air Force Medical University
2024
Cardiff University
2024
Beijing Friendship Hospital
2024
Feather is an important economic trait of poultry, and growth development state feathers plays role in the value poultry. Dermal fibroblasts are required for structural integrity skin feather follicle development. How FOXO3 affects as tissues change during goose embryo (Anser cygnoides) not well understood. Here, we demonstrate that vitro culture single tissue results changes morphological structure by adding drugs to medium affect expression. We used follicles show growth, root location...
Abstract Background Jilin white goose is an excellent local breed in China, with a high annual egg production and laying eggs mainly from February to July each year. The testis, as the only organ that can produce sperm, affect sexual maturity fecundity of male animals. Its growth development are affected regulated by variety factors. Proteomics generally applied identify quantify proteins cells tissues order understand physiological or pathological changes occur under specific conditions....
Microenvironment niches determine cellular fates of metastatic cancer cells. However, unbiased approaches to identify niche components and their molecular profiles are lacking. We established Sortase A-Based Niche Tagging (SAMENT), which selectively labels cells encountered by during colonization. SAMENT was applied multiple models colonizing the same organ different organs. Common features include macrophage enrichment T cell depletion. Macrophage phenotypically diverse between In bone,...
Tumor-associated neutrophils (TANs) have been shown to promote immunosuppression and tumor progression, a high TAN frequency predicts poor prognosis in triple-negative breast cancer (TNBC). Dysregulation of CREB-binding protein (CBP)/P300 function has observed with multiple types. The bromodomain (BRD) CBP/P300 regulate its activity. In this study, we found that IACS-70654, selective BRD inhibitor, reduced TANs inhibited the growth neutrophil-enriched TNBC models. bone marrow, inhibition...
Bone represents congenial soil for metastatic seeds and is frequently affected by metastasis of multiple cancer types. The histological molecular characteristics bone metastases (BMs) are diverse but poorly understood. Herein, we performed single-cell RNA-seq on 34 BMs from 6 types identified 3 ecosystem archetypes characterized enrichment macrophages/osteoclasts (Mφ-OC), regulatory/exhausted T cells (Treg-Tex), monocytes (Mono), respectively. Breast mostly the Mφ-OC archetype driven...
Renal cell carcinoma (RCC) bone metastatis progression is driven by crosstalk between tumor cells and the microenvironment, which includes osteoblasts, osteoclasts, osteocytes. RCC metastases (RCCBM) are predominantly osteolytic resistant to antiresorptive therapy. The molecular mechanisms underlying pathologic osteolysis disruption of homeostasis remain incompletely understood. We previously reported that BIGH3/TGFBI (transforming growth factor-beta-induced protein ig-h3, shortened BIGH3...
The goose industry represents a significant sector within the broader waterfowl in China, with early gonadal development playing pivotal role enhancing population productivity. Melatonin plays crucial regulating development, but molecular mechanism underlying effect of melatonin as regulator remains unclear. In this study, relationship between and egg production performance Jilin white was first established, then, an Ovo injection embryos on embryonic day 12 (E12) performed to evaluate...
The quantum Hall effect is one of the exclusive properties displayed by Dirac Fermions in topological insulators, which propagates along chiral edge state and gives rise to quantized electron transport. However, formed nondegenerate surface states has been elusive so far. Here, we demonstrate integer from three-dimensional (3D) insulator β-Ag2Te nanostructures. Surface-state dominant conductance renders plateaus with a step e2/h, typical thermopower behaviors two-dimensional (2D) massless...
Purpose: Older cancer patients are more likely to develop and die from chemotherapy-related toxicity. However, evidence on drug safety optimal effective doses is relatively limited in this group. The aim of study was a tool identify elderly vulnerable chemotherapy Patients methods: Elderly ≥60 years old who visited the oncology department Peking Union Medical College Hospital between 2008 2012 were included. Each round regarded as separate case. Clinical factors included age, gender,...
Background: Renal cell carcinoma (RCC) exhibits a metastatic nature and heterogeneous microenvironment, requiring improved comprehension of its pathogenesis. The role intratumoral microbiome in RCC's development is debated, despite reported influences. Previous studies' reliability uncertain due to sample sizes inadequate decontamination. Further research needed understand the connection between microbiome, immune landscape, prognosis. Methods: A study explored microbial landscape...
Abstract Tumor-associated neutrophils (TANs) have been shown to promote immunosuppression and tumor progression, a high TAN frequency predicts poor prognosis in triple-negative breast cancer (TNBC). Dysregulation of CREB binding protein (CBP)/P300 function has observed with multiple types. The bromodomain (BRD) CBP/P300 regulate its activity. In this study, we found that IACS-70654, novel selective BRD inhibitor, reduced TANs inhibited the growth neutrophil-enriched TNBC models. bone marrow,...
Microenvironment niches determine cellular fates of metastatic cancer cells. However, robust and unbiased approaches to identify niche components their molecular profiles are lacking. We established Sortase A-Based Niche Tagging (SAMENT), which selectively labels cells encountered by during colonization. SAMENT was applied multiple models colonizing the same organ different organs. Common features include macrophage enrichment T cell depletion. Macrophage phenotypically diverse between In...
SUMMARY Bone represents congenial soil for metastatic seeds and is frequently affected by metastasis of multiple cancer types. The histological molecular characteristics bone metastases (BMs) are diverse but poorly understood. Herein, we performed single-cell RNA-seq on 34 BMs from 6 types identified 3 ecosystem archetypes characterized enrichment macrophages/osteoclasts (Mφ-OC), regulatory/exhausted T cells (Treg-Tex), monocytes (Mono), respectively. Breast mostly the Mφ-OC archetype driven...