A5101478744- MicroRNA in disease regulation
- Chemokine receptors and signaling
- Immune cells in cancer
- Adenosine and Purinergic Signaling
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Histone Deacetylase Inhibitors Research
- Redox biology and oxidative stress
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Advanced Glycation End Products research
- Bone Metabolism and Diseases
- Pharmacological Effects of Natural Compounds
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Lipid metabolism and disorders
- Nitric Oxide and Endothelin Effects
- Pharmacological Effects and Toxicity Studies
- Bone health and treatments
- Atrial Fibrillation Management and Outcomes
- Takotsubo Cardiomyopathy and Associated Phenomena
- Beetle Biology and Toxicology Studies
Baylor College of Medicine
2023-2025
Yancheng Central Blood Station
2018-2024
Fuzhou Maternity and Child Health Care Hospital
2021-2022
Shanghai Ninth People's Hospital
2019
Shanghai Jiao Tong University
2019
Southwest Minzu University
2018
University of Saskatchewan
2004
Osteoporosis (OP) is a serious health problem that contributes to osteoporotic structural damage and bone fragility. MicroRNAs (miRNAs) can exert important functions over endocrinology. Therefore, it of substantial significance clarify the expression function miRNAs in endocrine physiology pathology improve potential therapeutic value for metabolism-related diseases. We explored effect microRNA-182-5p (miR-182-5p) on osteoblast proliferation differentiation OP rats after alendronate (ALN)...
BackgroundMany studies have demonstrated that microRNAs, a class of small and non-coding RNA molecules, play an important role in the regulation glucose lipid homeostasis. In present study, we sought to investigate function miR-592 development obesity-associated metabolic disorders, including hyperglycemia andinsulin resistance.MethodsThe expression levels were measured liver obese mice humans by quantitative reverse transcription PCR. Loss- gain-of experiments employed explore using locked...
This study aimed to investigate the mechanism by which microRNA-206 (miR-206) affects proliferation, apoptosis, migration and invasion of osteosarcoma (OS) cells targeting ANXA2 via AKT signaling pathway.A total 132 OS tissues 120 osteochondroma were examined in this study. The relationship between miR-206 was verified with a dual-luciferase reporter assay. expression ANXA2, AKT, PARP, FASN, Survivin, Bax, Mcl-1 Bcl-1 mRNA protein above two groups qRT-PCR western blotting. cultured divided...
The antihypertensive effect of the peroxisome proliferator-activated receptor (PPAR)gamma agonist rosiglitazone has been reported in patients with diabetes or obesity. correlation PPARgamma expression blood pressure and therapeutic application spontaneously hypertensive rats (SHR) were investigated present study. Systolic 21-week SHR was significantly higher than that age-matched Wistar-Kyoto (WKY) (225 +/- 5 v 144 2 mm Hg, P <.05). Basal levels proteins vascular tissues lower WKY (P This...
Microenvironment niches determine cellular fates of metastatic cancer cells. However, unbiased approaches to identify niche components and their molecular profiles are lacking. We established Sortase A-Based Niche Tagging (SAMENT), which selectively labels cells encountered by during colonization. SAMENT was applied multiple models colonizing the same organ different organs. Common features include macrophage enrichment T cell depletion. Macrophage phenotypically diverse between In bone,...
Microenvironment niches determine cellular fates of metastatic cancer cells. However, robust and unbiased approaches to identify niche components their molecular profiles are lacking. We established Sortase A-Based Niche Tagging (SAMENT), which selectively labels cells encountered by during colonization. SAMENT was applied multiple models colonizing the same organ different organs. Common features include macrophage enrichment T cell depletion. Macrophage phenotypically diverse between In...
Purpose: To study the effect of miR-23b on expression target gene acetaldehyde dehydrogenase 1A1 (ALDH1A1), and cisplatin (CDDP) susceptibility cervical carcinoma stem cells.
 Methods: Human cancer cell line Hela cells were cultured in vitro, mimic negative control transfected into using lipofectamine method. The growth two groups was determined curve method, their proliferation measured plate clone formation. influence treatments sensitivity to CDDP assayed MTT mRNA ALDH1A1 real-time...
Abstract In this study, we aim to discover the importance of long non-coding RNA cyclin-dependent kinase 6 (CDK6)-AS1 in lipopolysaccharide (LPS)-induced HK-2 cells. We treated cells with LPS and knocked down CDK6-AS1 then analyzed effects on viability cell, cell apoptosis, expression cytokines via MTT, flow cytometry, enzyme-linked immunosorbent assay (ELISA), qPCR. The results showed that silencing alleviated LPS-induced inhibition proliferation, release IL-1β, IL-8, IL-6, TNF-α, decrease...
Abstract Background Inflammation is the most common cause of kidney damage, and inflammatory responses in a number diseases are mediated by microRNA-338-3p (miR-338-3p). However, there only few reports which described regulation miR-338-3p human proximal tubular cells. The goal this study was to see how affected lipopolysaccharide (LPS)-caused response HK-2 Methods LPS used construct an model mimic increase levels MTT, JC-1 staining, apoptosis assays were detect cell viability, mitochondrial...