A5045738813- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Head and Neck Cancer Studies
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Stress Responses and Cortisol
- Inflammatory Bowel Disease
- Atherosclerosis and Cardiovascular Diseases
- Colorectal Cancer Treatments and Studies
- Pharmacological Effects of Natural Compounds
- Lung Cancer Research Studies
- Plant-Microbe Interactions and Immunity
- Traditional Chinese Medicine Analysis
- Healthcare and Venom Research
- Extracellular vesicles in disease
- Glaucoma and retinal disorders
- Glycosylation and Glycoproteins Research
- Hepatitis B Virus Studies
- Traditional Chinese Medicine Studies
- Cancer Cells and Metastasis
Kunming Medical University
2025
Dalian Medical University
2005-2025
Ministry of Agriculture and Rural Affairs
2020-2025
University of Science and Technology of China
2025
Second Affiliated Hospital of Dalian Medical University
2025
Nanjing Agricultural University
2020-2025
State Forestry and Grassland Administration
2025
Union Hospital
2021-2024
Huazhong University of Science and Technology
2021-2024
University of South China
2021-2024
Immune infiltration of tumors is closely associated with clinical outcome in renal cell carcinoma ( RCC ). Tumor‐infiltrating immune cells TIIC s) regulate cancer progression and are appealing therapeutic targets. The purpose this study was to determine the composition s further reveal independent prognostic values s. CIBERSORT , an established algorithm, applied estimate proportions 22 types based on gene expression profiles 891 tumors. Cox regression used evaluate association checkpoint...
Abstract Dendritic cells ( DC s) are potent and specialized antigen presenting cells, which play a crucial role in initiating amplifying both the innate adaptive immune responses against cancer. Tumor can escape from attack by secreting suppressive cytokines that solely or cooperatively impair function of s. However, underlying mechanisms not fully defined. Vascular endothelial growth factor VEGF ) has been identified as major cytokine tumor microenvironment. To elucidate effects on motility...
MicroRNAs (miRNAs) play a key role in various pathological processes like atrial fibrillation (AF), which is common cardiac arrhythmia. Exosomes are essential information carrier the intercellular communication. Therefore, this study aimed to investigate effects of exosomal miR-320d on cardiomyocytes with AF and related mechanisms. To do this, AMSCs were transfected mimics, AMSCs-derived exosomes co-cultured AF. MTT, TUNEL staining, flow cytometry, real-time PCR, western blots, luciferase...
Purpose: To determine the diagnostic value of individual image post-processing techniques in a series patients who underwent extratemporal operations for histologically proven, MRI-negative focal cortical dysplasia (FCD). Methods: The morphometric analysis program (MAP), PET/MRI co-registration and statistical parametric mapping (SPM) PET (SPM-PET) were analyzed 33 consecutive patients. epileptogenic zone (EZ) assumed by MAP, PET/MRI, SPM-PET was compared with location FCD lesions determined...
Acquired radio-resistance is thought to be one of the main causes recurrent metastasis after failure nasopharyngeal carcinoma (NPC) radiotherapy, which may related X-ray-induced epithelial–mesenchymal transition (EMT) activation. The circadian clock gene, BMAL1, has been shown correlate with sensitivity NPCs but specific mechanism not reported. NPC cells were irradiated by conventional fractionation generate radiotherapy-resistant cells. BMAL1 gene stabilization/overexpression and...
High-risk human papillomavirus (HPV) infection is strongly linked to the initiation and progression of cervical cancer, yet precise molecular mechanisms involved remain partially understood. This investigation examined differential protein expression profiles in various cohorts, including healthy controls HPV-positive cancer patients with different levels glucose-6-phosphate dehydrogenase (G6PD), shedding light on dysregulation oncogenic proteins by HPV. Proteomic analysis tissues revealed...
Black spot diseases caused by the necrotrophic fungal pathogen Alternaria alternata adversely affect growth and yield of many plants worldwide. However, molecular mechanisms underlying virulence pathogenicity A. remain largely unknown. In this study, we report identification a novel effector Alta1, secreted , which not only contributes to its but also triggers cell death defense host plant. The expression Alta1 in Chrysanthemum morifolium activated jasmonic acid (JA) signaling, which, turn,...
Alternaria species produce diverse secondary metabolites that act as critical virulence factors during plant pathogenesis. In cultivation areas of Chrysanthemum morifolium ‘Fubai’—a key cultivar for herbal tea—black spot disease caused by A. alternata manifests necrotic leaf lesions progressing to wilting. Despite this disease’s economic impact, information on its associated toxins is limited, and the types produced black pathogen ‘Fubai’ in particular remain unclear. Furthermore, whether...
Perimenopausal women are associated with increased risks of depression and anxiety, which may be potentially related to the lack ovarian hormone antidepression activity in body. However, precise mechanism remains unclear so far. This study first adopted Sprague-Dawley (SD) female rats construct ovariectomy (OVX) combined a chronic unpredictable stress (CUS) model. Then, series behavioral experimental results revealed that ovariectomized receiving CUS had remarkably elevated anxiety behaviors...
Objective Artemisinin is an organic compound that comes from Artemisia annua. treatment the most important and effective method for treating malaria. Bibliometric analysis was carried out to identify global research trends, hot spots, scientific frontiers, output characteristics of artemisinin 2000 2021. Methods Publications their recorded information 2021 were retrieved through Web Science Core Collection (WoSCC). Using VOSviewer Citespace, hotspots trends studies on visualized. Results A...
BMAL1 is a core circadian clock gene that expressed rhythmically in variety of tumor cells and related to cancer cell proliferation chemoradiotherapy sensitivity. Radiotherapy plays an important role the treatment nasopharyngeal carcinoma (NPC). However, rhythmicity NPC, as well its precise radiotherapy, remains unclear. We assessed changes expression over 48 h NPC normal epithelial NP69 using real-time quantitative polymerase chain reaction (RT-PCR) western blotting (WB). Then, we induced...