A5100653116- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Natural product bioactivities and synthesis
- Mast cells and histamine
- Systemic Lupus Erythematosus Research
- Skin and Cellular Biology Research
- T-cell and B-cell Immunology
- Autoimmune Bullous Skin Diseases
- Sulfur Compounds in Biology
- Wnt/β-catenin signaling in development and cancer
- Cell death mechanisms and regulation
- Cytokine Signaling Pathways and Interactions
- Signaling Pathways in Disease
- Reproductive System and Pregnancy
- interferon and immune responses
- Nuclear Receptors and Signaling
- Aldose Reductase and Taurine
- Animal Genetics and Reproduction
- Calpain Protease Function and Regulation
- Pigment Synthesis and Properties
- Fibroblast Growth Factor Research
- Pharmaceutical Economics and Policy
- Microbial metabolism and enzyme function
Sun Yat-sen Memorial Hospital
2012-2024
Sun Yat-sen University
2012-2024
Heilongjiang Bayi Agricultural University
2024
China Pharmaceutical University
2005-2024
Fujian Academy of Agricultural Sciences
2023
Huazhong University of Science and Technology
2016-2021
China Agricultural University
2020
China Three Gorges University
2013-2019
Union Hospital
2019
Yichang Central People's Hospital
2019
Background/Aim: Glycyrrhizin (GL) is an important derivative of certain herbal medicines used in Asian countries. Currently, GL to treat hepatitis and allergic disease worldwide because its anti-viral anti-allergy effects. In addition these prominent functions, likely regulates cellular functions such as tumor cell growth immunity. However, how affects the keratinocyte inflammation response remains poorly understood. The current paper investigates effect on psoriasis explores mechanisms...
Graphene oxide (GO), with its exceptional physical and chemical properties biocompatibility, holds a tremendous potential for sensing applications. In this study, GO, acting both as the electron-transfer bridge signal reporter, was attached on interface to develop label-free electrochemical nanosandwich device detection of interleukin-6 (IL-6). First, single layer GO covalently modified gold electrodes, followed by attachment anti-IL-6 capture antibody form interface. The 4-aminophenyl...
Mucosal-associated invariant T (MAIT) cells are nonconventional restricted to major histocompatibility complex class I-related protein 1 (MR1). They highly abundant in human liver and activated by T-cell receptor (TCR)-dependent TCR-independent mechanisms exhibit rapid, innate-like effector responses. However, the roles of MAIT chronic HBV infection still open for study. This study aims test their antiviral potential investigate dynamic changes regulating factors during infection.Blood...
Lupus erythematosus (LE) is a heterogeneous, antibody-mediated autoimmune disease. Isolate discoid LE (IDLE) and systematic (SLE) are traditionally regarded as the two ends of spectrum, ranging from skin-limited damage to life-threatening multi-organ involvement. Both belong LE, but IDLE SLE differ in appearance skin lesions, autoantibody panels, pathological changes, treatments, immunopathogenesis. Is lupus truly form or it completely separate entity? This question has not been fully...
Background/Aim: The abnormal activation of the AKT/GSK3β signal pathway in lymphocytes from systemic lupus erythematosus (SLE) patients plays an important role pathogenesis disease. Recently Hydrogen sulfide (H2S) has been recognized as a crucial gaseous signaling molecule, involved regulation cell proliferation. However, H2S regulating SLE not established. This study was conducted to investigate effect on and explore mechanisms involved. Methods: were isolated with or without renal disease...
Abstract Background: Psoriasis is a chronic inflammatory skin disease, affecting about 0.6% of the Chinese population. Many patients are not well controlled by conventional treatments, thus there need for new treatment regimens. In this study, we assessed efficacy and safety secukinumab in with moderate to severe plaque psoriasis. Methods: This study was 52-week, multicentre, randomized, double-blind, placebo-controlled, parallel-group, Phase 3 trial. A sub-population participants (≥18...
Psoriasis, characterized by circumscribed, red, thickened plaques with an overlying silver-white scale, is a common T-cell-mediated chronic inflammatory skin disease. Although hydrogen sulfide (H2S) has been shown to be signaling molecule both pro- or anti-inflammatory effects, its relationship psoriasis not elucidated. In the present study, 15 patients progressive and healthy volunteers were investigated. Serum H2S levels in significantly lower than those of controls (16.69 ± 5.47 μM vs....
Objective Orchitis is a common reproductive disease of male animals, which has serious implications to human and animal reproduction. Additionally, phlorizin (PHN), polyphenol in apples strawberries, variety biological activities, including antioxidant, anti-inflammatory, anti-diabetic, anti-aging activities. We aimed determine the protective effects potential mechanisms PHN lipopolysaccharide (LPS)-induced acute orchitis mice. Method After 21 days pretreatment, mice were injected with LPS...
Abnormal expressions of long noncoding RNAs (lncRNAs) are very common in clear cell renal carcinoma (ccRCC), and some these have been reported to be highly correlated with prognosis ccRCC patients. "edgeR" AND "DEseq" R packages were used explore differentially expressed genes (DEGs) between normal tumor tissues samples from The Cancer Genome Atlas (TCGA). Univariable Cox survival analysis, robust likelihood-based model multivariable regression analysis identify prognostic lncRNAs construct...
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease accompanied by the activation and proliferation of T cells B cells. In this study, we found that distributions lymphocytes obtained from patients with SLE or renal (RSLE) were reduced in G0/G1 phase elevated S after phytohemagglutinin treatment. Increased expression CDK2 decreased cyclin-dependent kinase inhibitors p27Kip1 p21WAF1/CIP1 observed RSLE lymphocytes. The phosphorylation levels Akt473 GSK3β (ser9) increased...
Phenotypic switching of vascular smooth muscle cells (VSMCs) plays an initial role in neointimal hyperplasia, the main cause many occlusive diseases. The aim this study was to measure effects resveratrol (RSV) on phenotypic transformation VSMCs and investigate its mechanism action.Cultured isolated from rat thoracic aorta were prepared with serum starvation for 72 hours followed by RSV treatment (50-200 μmol/L) 10% stimulation. Male Sprague-Dawley rats, subjected carotid arteries injury a...
A cutaneous squamous cell carcinoma (cSCC) derived from keratinocytes is the second most common cause of non-melanoma skin cancer. The accumulation mutational burden genes and cellular DNA damage caused by risk factors (e.g., exposure to ultraviolet radiation) contribute aberrant proliferation formation a cSCC. cSCC encompasses spectrum diseases that range recursor actinic keratosis (AK) (SCC) in situ (SCCIS) invasive cSCCs further metastatic SCCs. Emerging evidence has revealed lncRNAs are...
Adalimumab has been used successfully in the treatment of psoriasis. The objective study is to compare efficacy, safety, and immunogenicity between HLX03, an adalimumab biosimilar, Chinese patients with moderate-to-severe plaque In this double-blind, active-controlled, parallel-group study, 262 psoriasis were randomized (1:1) receive HLX03 or (80 mg at week 1, 40 2, then every 2 weeks) for 48 weeks. primary endpoint was improvement Psoriasis Area Severity Index (PASI) score 16 comparing...