A5045790485- Immune Cell Function and Interaction
- Research in Cotton Cultivation
- Immunotherapy and Immune Responses
- Plant and Fungal Interactions Research
- Plant Virus Research Studies
- Immune cells in cancer
- Cytomegalovirus and herpesvirus research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- T-cell and B-cell Immunology
- Bioactive natural compounds
- Ginseng Biological Effects and Applications
- Phagocytosis and Immune Regulation
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Biochemical Acid Research Studies
- vaccines and immunoinformatics approaches
- Lung Cancer Treatments and Mutations
- Chemical synthesis and alkaloids
- Advanced Cellulose Research Studies
- Liver Disease Diagnosis and Treatment
- Quinazolinone synthesis and applications
- Liver Diseases and Immunity
- Botanical Research and Applications
- Pharmacogenetics and Drug Metabolism
- Asthma and respiratory diseases
Huazhong University of Science and Technology
2015-2025
Huazhong Agricultural University
2018-2025
Fujian Medical University
2024
Tongji University
2023
Inner Mongolia Agricultural University
2019-2022
Shanghai Veterinary Research Institute
2022
Chinese Academy of Agricultural Sciences
2022
Guangxi Subtropical Crops Research Institute
2021
Summary Brown fibre cotton is an environmental‐friendly resource that plays a key role in the textile industry. However, quality and yield of natural brown are poor, fundamental research on relatively scarce. To understand genetic basis cotton, we constructed linkage association populations to systematically examine accessions. We fine‐mapped region, Lc 1 , dissected it into 2 loci, qBF ‐A07‐1 ‐A07‐2 . The locus mediates initiation production, whereas shade affected by interaction between...
Abstract CD1d-restricted invariant natural killer T (iNKT) cells actively patrol the liver and possess valuable antitumor potential. However, clinical trials evaluating administration of iNKT cell–specific agonist α-galactosylceramide (α-GalCer) have failed to achieve obvious tumor regression. Improving efficacy cell–based immunotherapy requires a better understanding factors restraining benefits. In context hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), we found circulating...
Abstract Extracellular regulated protein kinases (ERK) signaling is a master regulator of cell behavior, life, and fate. Although ERK pathway shown to be involved in T‐cell activation, little known about its role the development allograft rejection. Here, it reported that activated allograft‐infiltrating T cells. On basis surface plasmon resonance technology, lycorine identified as an ERK‐specific inhibitor. inhibition by significantly prolongs survival stringent mouse cardiac allotransplant...
Mucosal-associated invariant T (MAIT) cells are nonconventional restricted to major histocompatibility complex class I-related protein 1 (MR1). They highly abundant in human liver and activated by T-cell receptor (TCR)-dependent TCR-independent mechanisms exhibit rapid, innate-like effector responses. However, the roles of MAIT chronic HBV infection still open for study. This study aims test their antiviral potential investigate dynamic changes regulating factors during infection.Blood...
Mucosal-associated invariant T (MAIT) cells exert multifaceted effects such as anti-microbial activity, tissue repair, and pro-fibrotic across various disease settings. Nonetheless, their role in liver injury hemostasis remains debated. Here, we report a significant depletion functional dysregulation of MAIT cells, which is associated with severity accumulated bile acids HBV-infected patients varying degree injury. Liver transplantation facilitates gradual recovery recipient-originated...
Mucosal-associated invariant T cells (MAIT) are emerging as important regulators at mucosal surfaces. While these have been linked to a Th1-biased immune response and support for B cells, their roles in allergic diseases characterised by type 2 inflammation remain elusive. The study seeks characterise MAIT house dust mite (HDM)-induced rhinitis (AR) subsequent allergen immunotherapy (AIT), aiming elucidate clinical significance AR potential enhance AIT effectiveness. were assessed patients...
Sea-island cotton (Gossypium barbadense, Gb) is one of the major sources high-grade natural fiber. Besides common annual Gb cotton, perennial also cultivated, but studies on are rare.We aimed to make a systematic analysis sea-island and lay foundation for its utilization in breeding, try identify representative structural variations (SVs) reveal population differentiation adaptive improvement cotton.Through genome assembly accession (named Gb_M210936) comparative analysis, during...
A cutaneous squamous cell carcinoma (cSCC) derived from keratinocytes is the second most common cause of non-melanoma skin cancer. The accumulation mutational burden genes and cellular DNA damage caused by risk factors (e.g., exposure to ultraviolet radiation) contribute aberrant proliferation formation a cSCC. cSCC encompasses spectrum diseases that range recursor actinic keratosis (AK) (SCC) in situ (SCCIS) invasive cSCCs further metastatic SCCs. Emerging evidence has revealed lncRNAs are...
Infectious laryngotracheitis virus (ILTV) causes severe respiratory disease in chickens and results huge economic losses the poultry industry worldwide. To correlate genomic difference with replication pathogenicity, phenotypes of three ILTVs isolated from China 2016 to 2018 were sequenced by high-throughput sequencing. Based on entire genome, isolates GD2018 SH2017 shared 99.9% nucleotide homology, while isolate SH2016 99.7% homology SH2017, respectively. Each genome contained 82 ORFs...
Abstract Background The development of pulmonary fibrosis involves a cascade events, in which inflammation mediated by immune cells plays pivotal role. Chemotherapeutic drugs have been shown to dual effects on fibrosis, with bleomycin exacerbating and bortezomib alleviating tissue fibrotic processes. Understanding the intricate interplay between chemotherapeutic drugs, responses, is likely serve as foundation for crafting tailored therapeutic strategies. Methods A model bleomycin-induced was...
Ticks are important vectors and reservoirs of several zoonotic pathogens. Recently, both known unknown tick-borne pathogens have emerged re-emerged, causing unpredictable epidemics. In this study, 211 soft tick samples were collected from Tongliao Alxa in Inner Mongolia, China. Tick species identified by morphological molecular biological analyses. Morphological analysis showed that there was no significant difference surface features between ticks the 2 areas. Cloning polymerase chain...
Community-acquired pneumonia (CAP) remains the significant infectious cause of morbidity and mortality worldwide. Although mucosal-associated invariant T cells (MAIT) play roles in pathogenesis children CAP ICU-associated pneumonia, their adult are largely unexplored. In this study, we investigated frequency, phenotype, function MAIT peripheral blood bronchoalveolar lavage fluid (BALF) patients. Our data indicate that MAIT-cell frequency is profoundly lower patients compared to healthy...
Agave angustifolia is commonly used for the production of bacanora, a kind fermented and distilled beverage in Mexico. In present study, we have successfully assembled its chloroplast genome. The full length genome 157,274 bp with GC content 37.84%. There large single copy region (LSC) 85,895 bp, pair inverted repeat regions (IR) 26,575 small (SSC) 18,229 A total 132 genes are annotated cp Among these, there 86 protein-coding genes, 38 tRNAs 8 rRNAs. Phylogenetic analysis reveals that A....
Abstract Preterm birth (PTB) is a major problem affecting perinatal health, directly increasing the mortality risk of mother and infant that often results from breakdown maternal–fetal immune balance. Increasing evidence shows essential role mucosal-associated invariant T (MAIT) cells to balance antibacterial function tolerance during pregnancy. However, phenotype placental MAIT their specific mechanisms in PTB remain unclear. Here, we report placentas PTBs show increased activation levels...
Abstract Background The development of pulmonary fibrosis entails a cascade events, where immune cell-mediated inflammation plays central role. Chemotherapeutic drugs have been observed to exert dual impacts on fibrosis, with bleomycin exacerbating and bortezomib alleviating tissue fibrotic processing. Understanding the complex interactions between chemotherapeutic drugs, responses, is likely serve as foundation for crafting tailored therapeutic strategies. Methods A bleomycin-induced model...
<title>Abstract</title> Mucosal-associated invariant T (MAIT) cells exert multifaceted effects such as anti-microbial activity, tissue repair, and pro-fibrotic across various disease settings. Nonetheless, their role in liver injury hemostasis is a current topic of debate. Here, we presented MAIT cell-centered profiling chronic HBV-infected patients with varying degree those who underwent transplantation. Liver transplantation facilitated gradual recovery recipient-originated from...
Background Mutations commonly occur in cancer cells, arising neoantigen as potential targets for personalized immunotherapy of lung adenocarcinoma (LUAD). However, the substantial heterogeneity observed among individuals and distinct foci within same patient presents significant challenges formulating strategies. The aim work is to characterize mutation pattern identify neopeptides across different patients diverse with LUAD. Methods Seven samples matched tissues/blood are collected from 4...