A5019839063- Immune Cell Function and Interaction
- Tracheal and airway disorders
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Acute Myeloid Leukemia Research
- Airway Management and Intubation Techniques
- T-cell and B-cell Immunology
- Muscle Physiology and Disorders
- Myasthenia Gravis and Thymoma
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- IL-33, ST2, and ILC Pathways
- Skin and Cellular Biology Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Peripheral Neuropathies and Disorders
- Parkinson's Disease and Spinal Disorders
- Cell Adhesion Molecules Research
- Hematological disorders and diagnostics
- Foreign Body Medical Cases
- Voice and Speech Disorders
- Psoriasis: Treatment and Pathogenesis
- Hereditary Neurological Disorders
- Wnt/β-catenin signaling in development and cancer
- Clinical Laboratory Practices and Quality Control
Yangzhou University
2018-2025
Second Affiliated Hospital of Guangzhou Medical University
2019-2025
Guangzhou Medical University
2003-2025
Second Hospital of Shandong University
2024
Capital Medical University
2013-2024
Affiliated Hospital of Nantong University
2024
Nantong University
2024
Yancheng Third People's Hospital
2024
Hospital of Hebei Province
2024
University of Iowa
2024
Colony stimulating factor 1 (CSF1) and interleukin 34 (IL34) signal via the CSF1 receptor to regulate macrophage differentiation. Studies in IL34- or CSF1-deficient mice have revealed that IL34 function is limited central nervous system skin during development. However, roles of at homeostasis context inflammatory diseases cancer wild-type not been clarified vivo. By neutralizing and/or adult mice, we identified they play important differentiation, specifically steady state microglia,...
Overexpression of HER-2/neu (c-erbB2) is associated with increased risk recurrent disease in ductal carcinoma situ (DCIS) and a poorer prognosis node-positive breast cancer. We therefore examined the early immunotherapeutic targeting DCIS. Before surgical resection, HER-2/neu(pos) DCIS patients (n = 13) received 4 weekly vaccinations dendritic cells pulsed HLA class I II peptides. The vaccine were activated vitro IFN-gamma bacterial lipopolysaccharide to become highly polarized DC1-type that...
We examined hematopoietic protein kinase 1 (HPK1), whose reliance on scaffold versus functions for negative immune cell regulation is poorly understood and critical to its assessment as a viable drug target. identify kinase-dependent roles HPK1 in CD8 T cells that restrict their anti-viral anti-tumor responses by using kinase-dead (HPK1.kd) knockin mice. Loss of function enhanced receptor signaling cytokine secretion T-cell-intrinsic manner. In response chronic lymphocytic choriomeningitis...
Abstract The recently delineated role for IL-23 in enhancing Th-17 activity suggests that regulation of its expression is distinct from IL-12. We hypothesized independent TLR-mediated pathways are involved the IL-12 and production by myeloid-derived dendritic cells (DCs). TLR 2 ligand, lipoteichoic acid (LTA), 4 LPS, 7/8 resimiquod (R848), induced DCs. None these ligands alone significant production, except when combined with IFN-γ or other ligands. Notably, response to single was inhibited...
The FilmArray respiratory virus panel detects 15 viral agents in specimens using polymerase chain reaction. We performed testing a core laboratory at regional children's hospital that provides service 24 hours day 7 days week. average and median turnaround time were 1.6 1.4 hours, respectively, contrast to 6.5 documented 1 year previously an on-site reference direct fluorescence assay (DFA) detected 8 agents. During the study period, rhinovirus was 20% coronavirus 6% of samples FilmArray;...
Background There is evidence suggesting that sirolimus, in combination with tacrolimus, active the prevention of graft-versus-host disease. Sirolimus-based immune suppression may suppress alloreactive T cells, while sparing survival and function regulatory cells.Design Methods We conducted a randomized trial to compare impact sirolimus/tacrolimus against methotrexate/tacrolimus on disease T-cell reconstitution.Results Seventy-four patients were 1:1 or methotrexate/tacrolimus, stratified for...
Abstract Excessive mitochondrial fission has been identified as the pathogenesis of diabetic nephropathy (DN), although upstream regulatory signal for activation in setting DN remains unknown. In current study, we found that dual‐specificity protein phosphatase‐1 (DUSP1) was actually downregulated by chronic hyperglycemia stimulus. Lower DUSP1 expression associated with glucose metabolism disorder, renal dysfunction, kidney hypertrophy, fibrosis, and glomerular apoptosis. At molecular level,...
Background/Aims: Amniotic fluid stem cells (AFSCs) transplantation is a promising therapeutic strategy for diabetic nephropathy. Sirtuin3 (SIRT3) novel mitochondrial protective factor. In the present study, we aimed to investigate whether SIRT3 protects against hyperglycemia-induced AFSCs damage and enhances efficiency of in Methods: To establish nephropathy model, db/ db mice were used. obtained transplanted into kidney tissue mice. Gain-of-function assay with overexpression was performed...
Abstract Background Flexible fiberoptic bronchoscopy is a rapid, cost effective and safe procedure. Aim To analyze demographic information endoscopic findings in adult patients with airway foreign body aspiration its removal. Methods Fifty-seven adults (40 males, 17 females; average age 40 years old) were analyzed. Cough (37, 65%) was the most common clinical presentation. The bone followed by dental prosthesis food debris. Results In current study, 42 out of 57 (74%) bodies successfully...
This study aims to detect Mycobacterium tuberculosis complex (MTBC) DNA in intraocular fluid from clinically suspected tuberculous uveitis patients using multiplex polymerase chain reaction (PCR) and investigate the diagnostic utility of PCR for uveitis. Primers targeting three specific genes (MPB64, CYP141, IS6110) within MTBC genome were designed. Multiplex was conducted H37Rv strain as well extracted fluids confirmed assess primer specificity method feasibility. Intraocular samples...
Objective Netherton syndrome (NS) is a rare hereditary dermatosis, and the correlation between genotype phenotype in this disease warrants further investigation. This study aimed to explore genotype-phenotype NS. Methods We collect cases from our clinic relevant literature. After rigorous screening, we included 162 patients with NS-associated symptoms SPINK5 mutations. characterized distribution mutation types of allele variants. Logistic regression was employed analyze location these...
Objectives: The high failure rate of small-molecule drug development, primarily due to efficacy and safety concerns, has been widely discussed in discovery, including challenges validating new targets, limited predictive abilities animal models, etc.1 However, a potential reason that not raised is the selection unsuited lead candidates some unideal preclinical pharmacokinetic (PK) criteria, such as preference selecting compounds with adequate plasma exposure half-life candidates. These...
Eosinophilic inflammation and Th2 cytokine production are central to the pathogenesis of asthma. Agents that target either eosinophils or single cytokines have shown benefits in subsets biomarker-positive patients. More broadly effective treatment disease-modifying effects may be achieved by eliminating more than one inflammatory stimulator. Here we present a strategy concomitantly deplete T cells, eosinophils, basophils, type-2 innate lymphoid cells (ILC2s) generating monoclonal antibodies...
Abstract In an effort to identify acute myeloid leukemia (AML)-restricted targets for therapeutic development in AML, we analyzed the transcriptomes of 2051 children and young adults with AML compared expression profile normal marrow specimens. This analysis identified a large cohort AML-restricted genes high but low no hematopoiesis. Mesothelin (MSLN), known target solid tumors, was shown be highly overexpressed 36% (range, 5-1077.6 transcripts per million [TPM]) virtually absent 0.1-10.7...
Peptidoglycan recognition proteins (PGRPs) constitute a family of innate immune molecules. In Drosophila, distinct PGRPs bind to peptidoglycans on gram-positive or gram-negative bacteria and provide essential signals upstream the Toll Imd pathways required for immunity against infection. Four PGRPs, PGRP-L, -S, -Ialpha, -Ibeta, are expressed from three genes in mammals. this paper, we direct evidence that longest member, is secreted serum protein with capacity multimerize. Using gene...
Neurofibromatosis type I is a rare neurocutaneous syndrome resulting from loss-of-function mutations of NF1. The present study sought to determine correlations between mutation regions on NF1 and the risk developing optic pathway glioma (OPG) in patients with neurofibromatosis I. A total 215 I, our clinic or previously reported literature, were included after applying strict inclusion exclusion criteria. Of these, 100 OPG classified into group 115 without (aged ≥ 10 years) assigned Non-OPG...