A5073757291- Ubiquitin and proteasome pathways
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- RNA Interference and Gene Delivery
- interferon and immune responses
- IL-33, ST2, and ILC Pathways
- Protein Degradation and Inhibitors
- Eosinophilic Esophagitis
- Bacteriophages and microbial interactions
- Bacterial biofilms and quorum sensing
- Toxoplasma gondii Research Studies
- Phagocytosis and Immune Regulation
- Antibiotic Resistance in Bacteria
- Asthma and respiratory diseases
Pseudomonas aeruginosa causes life-threatening infections that are associated with antibiotic failure. Previously, we identified the G2637, an analog of arylomycin, targeting bacterial type I signal peptidase, which has moderate potency against P. aeruginosa. We hypothesized antibody-antibiotic conjugate (AAC) could increase its activity by colocalizing bacteria high local concentrations G2637 in intracellular environment phagocytes. Using a novel technology screening for hybridomas...
Eosinophilic inflammation and Th2 cytokine production are central to the pathogenesis of asthma. Agents that target either eosinophils or single cytokines have shown benefits in subsets biomarker-positive patients. More broadly effective treatment disease-modifying effects may be achieved by eliminating more than one inflammatory stimulator. Here we present a strategy concomitantly deplete T cells, eosinophils, basophils, type-2 innate lymphoid cells (ILC2s) generating monoclonal antibodies...
Ubiquitination is a posttranslational modification that crucial for the dynamic regulation of diverse signaling pathways. To enhance our understanding ubiquitination-mediated signaling, we generated new class bispecific antibodies combine recognition ubiquitination substrates and specific polyubiquitin linkages. RIP1-K63 RIP1–linear (Lin) linkage detected linkage-specific proinflammatory kinase RIP1 in cells tissues revealed by immunofluorescence. Similarly, RIP1-related RIP2 with K63 or...