A5056957943- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Asthma and respiratory diseases
- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
- DNA Repair Mechanisms
- PI3K/AKT/mTOR signaling in cancer
- IL-33, ST2, and ILC Pathways
- Lung Cancer Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Ferroptosis and cancer prognosis
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- RNA Research and Splicing
- Immune cells in cancer
- Circular RNAs in diseases
- Dermatology and Skin Diseases
- Molecular Biology Techniques and Applications
- Epigenetics and DNA Methylation
- Hepatitis B Virus Studies
- Colorectal Cancer Surgical Treatments
- Glioma Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Southern Medical University
2015-2025
Beijing Microelectronics Technology Institute
2024
Jiangmen Central Hospital
2021-2024
Sun Yat-sen University
2021-2024
Dalian Medical University
2019-2024
First Affiliated Hospital of Dalian Medical University
2019-2024
Army Medical University
2024
National Health and Family Planning Commission
2023
Qingdao University
2023
Key Laboratory of Guangdong Province
2023
Thymic stromal lymphopoietin (TSLP) potently induces deregulation of Th2 responses, a hallmark feature allergic inflammatory diseases such as asthma, atopic dermatitis, and rhinitis. However, direct downstream in vivo mediators the TSLP-induced immune cascade have not been identified. In our current study, we shown that OX40 ligand (OX40L) is critical mediator TSLP-mediated responses. Treating mice with OX40L-blocking antibodies substantially inhibited responses induced by TSLP lung skin,...
Glycolytic reprogramming is a typical feature of many cancers; however, key regulators glucose metabolism reengineering are poorly understood, especially in cutaneous squamous cell carcinoma (cSCC). Here, Homeobox A9 (HOXA9), direct target onco-miR-365, identified to be significantly downregulated cSCC tumors and lines. HOXA9 acts as tumor suppressor inhibits glycolysis vitro vivo by negatively regulating HIF-1α its downstream glycolytic regulators, HK2, GLUT1 PDK1. Mechanistic studies show...
IgE-mediated hypersensitivity is central to the pathogenesis of asthma and other allergic diseases. Although neutralization serum IgE with IgE-specific antibodies in general an efficacious treatment for asthma, one limitation this approach its lack effect on production. Here, we have developed a strategy disrupt production by generating monoclonal that target segment membrane human IgE-switched B cells not present IgE. This known as M1' domain, using genetically modified mice contain domain...
Aberrant expression of microRNAs plays vital roles in tumor development and progression. As transcription factors (TFs) are the critical components signaling cascades, specific targeting effects to TFs may determine role different cancers. In this study, we identified Nuclear Factor I/B (NFIB) as one targets miR-365 which was previously verified an onco-miR cutaneous squamous cell carcinoma (CSCC). Down-regulation NFIB a general feature both CSCC lines tumors from patients show drastically...
The determination of a causal association between gut microbiota and range dyslipidemia remains uncertain. To clarify these associations, we employed two-sample Mendelian randomization (MR) analysis utilizing the inverse-variance weighted (IVW) method. This comprehensive investigated genetic variants that exhibited significant (p < 5 × 10-8) with 129 distinct genera their potential link to different types dyslipidemia. results indicated 22 in humans. Furthermore, findings suggested impact on...
The aim of this study was to assess the causal relationships between mineral metabolism disorders, representative trace elements, and key aging biomarkers: telomere length (TL) mitochondrial DNA copy number (mtDNA-CN). Utilizing bidirectional Mendelian randomization (MR) analysis in combination with two-stage least squares (2SLS) method, we explored disorders these indicators. Sensitivity can be used determine reliability robustness research results. results confirmed that a positive...
The expression levels of miR-365 vary in different malignancies. Herein, we found that was overexpressed both cells and clinical specimens cutaneous squamous cell carcinoma (SCC). We demonstrated the HaCaT pre-miR-365-2 line, which miR-365, could induce subcutaneous tumors vivo . Antagomir-365, an anti-miR-365 oligonucleotide, inhibited tumor formation , along with G 1 phase arrest apoptosis cancer cells. These findings suggest may act as onco-miR SCC vitro present study provides valuable...
Cervical cancer is one of the most common causes cancer-related mortality in women developing countries. Interferon (IFN)-α has been widely used treatment various types cancer, including cervical and IFN-stimulated gene 15 (ISG15), an ubiquitin-like protein, upregulated by IFN-α treatment. The anti-virus antitumor effects ISG15 have reported; however, its mechanism action not yet fully elucidated. In this study, HeLa cells were as a model system to investigate roles IFN-α-mediated cell...
Long noncoding RNAs (LncRNAs), including MALAT1, are critical regulators of tumor development. However, the roles and molecular mechanisms LncRNAs in cutaneous squamous cell carcinoma (cSCC) remain underexplored. In this study, functional studies using vitro cellular vivo xenograft models confirmed pro-carcinogenic MALAT1 cSCC. Further, was identified to regulate epidermal growth factor receptor (EGFR) protein expression but did not affect EGFR mRNA expression. Transcriptomic sequencing...
Abstract Background Bleomycin, a potent antitumor agent, is limited in clinical use due to the potential for fatal pulmonary toxicity. The accelerated DNA damage and senescence alveolar epithelial cells (AECs) considered key factor development of lung pathology. Understanding mechanisms bleomycin-induced injury crucial mitigating its adverse effects. Methods Human (A549) were exposed bleomycin subsequently assessed cellular senescence, damage, double-strand break (DSB) repair. impact Rad51...
Existing research indicates that different types of meat have varying effects on health and aging, but the specific causal relationships remain unclear. This study aimed to explore relationship between intake aging-related phenotypes. employed Mendelian randomization (MR) select genetic variants associated with from large genomic databases, ensuring independence pleiotropy-free nature these instrumental variables (IVs), calculated F-statistic evaluate strength IVs. The validity estimates was...
This study comprehensively investigated keratinocyte subpopulation heterogeneity and developmental trajectories during skin aging using single-cell sequencing, transcriptomics, facial aging-related genome-wide association studies (GWAS) data. We identified three major subpopulations: basal cells (BCs), spinous (SCs), IFI27+ keratinocytes. Single-cell pseudotime analysis revealed that can differentiate along two distinct paths: toward differentiation or the inflammatory state. With aging,...
Abstract MicroRNAs (miRNAs) are known as a kind of small, noncoding RNA, which play an important role in mediating many biological processes such development, cell proliferation and differentiation plants animals. Here we report the differential expression profiles miRNAs characterized putative target genes NIH3T3 cells at series different time points after UVB irradiation (compared with no irradiation). The relative mature miRNA was determined by microarray technique results were confirmed...
The aim of the present study was to identify potential key genes associated with progression and prognosis colorectal cancer (CRC). Differentially expressed (DEGs) between CRC normal samples were screened by integrated analysis gene expression profile datasets, including Gene Expression Omnibus (GEO) Cancer Genome Atlas. ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway conducted biological role DEGs. In addition, a protein‑protein interaction network survival used genes....
Introduction Gestational diabetes mellitus (GDM), a common complication of pregnancy, is risky for both mother and fetus. Previous studies about TP53-induced glycolysis apoptosis regulator (TIGAR) focused on the occurrence development cancer, cardiovascular disease, neurological however, it still unclear whether TIGAR plays regulatory role in gestational (GDM). Methods Utilizing HG exposure, we explored oxidative stress limitation, excessive inflammatory toxicity defense, pyroptosis...
The kinase ITK is required for antigen-stimulated T cell death.