A5014032907- Trypanosoma species research and implications
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Immune Response and Inflammation
- Research on Leishmaniasis Studies
- Cancer Immunotherapy and Biomarkers
- Peroxisome Proliferator-Activated Receptors
- Immune cells in cancer
- Parasites and Host Interactions
- Caveolin-1 and cellular processes
- Pluripotent Stem Cells Research
- Animal Behavior and Welfare Studies
- Cellular transport and secretion
- Inflammation biomarkers and pathways
- COVID-19 Clinical Research Studies
- Palliative and Oncologic Care
- Erythrocyte Function and Pathophysiology
- Regulation of Appetite and Obesity
- Congenital heart defects research
- Pharmacological Effects of Natural Compounds
- Adipokines, Inflammation, and Metabolic Diseases
- Sphingolipid Metabolism and Signaling
- Macrophage Migration Inhibitory Factor
- Ion channel regulation and function
- Lipid metabolism and biosynthesis
Universidade Federal de Juiz de Fora
2009-2024
Cardiovascular Institute of the South
2017-2018
Stanford University
2012-2018
Fundação Oswaldo Cruz
2003-2016
University of Maryland, College Park
2013-2014
Coordenação de Aperfeicoamento de Pessoal de Nível Superior
2013
Ministry of Education
2013
Instituto Evandro Chagas
2012
Peking University
2012
University of California, Davis
2012
Colony stimulating factor 1 (CSF1) and interleukin 34 (IL34) signal via the CSF1 receptor to regulate macrophage differentiation. Studies in IL34- or CSF1-deficient mice have revealed that IL34 function is limited central nervous system skin during development. However, roles of at homeostasis context inflammatory diseases cancer wild-type not been clarified vivo. By neutralizing and/or adult mice, we identified they play important differentiation, specifically steady state microglia,...
Abstract Macrophages have important roles in both lipid metabolism and inflammation are central to immunity intracellular pathogens. Foam-like, lipid-laden macrophages present during the course of mycobacterial infection recently been implicated pathogenesis. In this study, we analyzed molecular mechanisms underlying formation macrophage bodies (lipid droplets) Mycobacterium bovis bacillus Calmette-Guérin (BCG) infection, focusing on role lipid-activated nuclear receptor peroxisome...
Rapid repair of plasma membrane wounds is critical for cellular survival. Muscle fibers are particularly susceptible to injury, and defective sarcolemma resealing causes muscular dystrophy. Caveolae accumulate in dystrophic muscle caveolin cavin mutations cause pathology, but the underlying mechanism unknown. Here we show that other cell types by a involving Ca2+-triggered exocytosis lysosomes, release acid sphingomyelinase, rapid lesion removal caveolar endocytosis. Wounding or exposure...
Induced pluripotent stem cells (iPSCs) hold great promise for the development of patient-specific therapies cardiovascular disease. However, clinical translation will require preclinical optimization and validation large-animal iPSC models.To successfully derive endothelial from porcine iPSCs demonstrate their potential utility treatment myocardial ischemia.Porcine adipose stromal were reprogrammed to generate (piPSCs). Immunohistochemistry, quantitative PCR, microarray hybridization,...
Leptin is an adipocyte-derived hormone/cytokine that links nutritional status with neuroendocrine and immune functions. Lipid bodies (lipid droplets) are emerging as dynamic organelles roles in lipid metabolism inflammation. Here we investigated the of leptin signaling pathways involved cytoplasmic body biogenesis leukotriene B(4) synthesis macrophages. Our results demonstrated directly activated macrophages induced formation adipose differentiation-related protein-enriched bodies. Newly...
We recently showed that Mycobacterium leprae (ML) is able to induce lipid droplet formation in infected macrophages. herein confirm cholesterol (Cho) one of the host molecules accumulate ML-infected macrophages and investigate effects ML on cellular Cho metabolism responsible for its accumulation. The expression levels LDL receptors (LDL-R, CD36, SRA-1, SR-B1, LRP-1) enzymes involved biosynthesis were investigated by qRT-PCR and/or Western blot shown be higher lepromatous leprosy (LL)...
Tuberculosis continues to be a global health threat, with drug resistance and HIV coinfection presenting challenges for its control. Mycobacterium tuberculosis, the etiological agent of is highly adapted pathogen that has evolved different strategies subvert immune metabolic responses host cells. Although significance peroxisome proliferator-activated receptor gamma (PPARγ) activation by mycobacteria not fully understood, recent findings are beginning uncover critical role PPARγ during...
Bacterial clearance is one of the most important beneficial consequences innate immune response. Chemokines are mediators controlling leukocyte trafficking and activation, whereas reactive oxygen nitrogen species effectors in bacterial killing. In present work, we used vivo vitro models infections to study role monocyte chemoattractant protein 1 (MCP-1)/CCL2 nitric oxide (NO) sepsis. Our results show that MCP-1/CCL2 NO levels increased peritoneal cavity mice 6 h after sepsis induced by cecal...
Parasite‐derived lipids may play important roles in host‐pathogen interactions and escape mechanisms. Herein, we evaluated the role of schistosomal‐derived Toll‐like receptor (TLR)-2 eosinophil activation Schistosoma mansoni infection. Mice lacking TLR2 exhibited reduced liver eosinophilic granuloma, compared with that wild‐type animals, following S. Decreased accumulation lipid body (lipid droplet) formation, at least partially due to production eotaxin, interleukin (IL)‐5, IL‐13...
Leptin directly activates macrophages and lymphocytes, but the role of leptin in neutrophil activation migration is still controversial. Here we investigate vivo mechanisms induced by leptin. Intraperitoneal injection (1 mg/Kg) induces a time- concentration-dependent influx. We did not observe enhancement lipid bodies/droplets neutrophils, after treatment, as had observed previously peritoneal macrophages. The participation LTB4 recruitment triggered was investigated using different...
There is growing interest in using embryonic stem cell (ESC) and induced pluripotent (iPSC) derivatives for tissue regeneration. However, an increased understanding of human immune responses to cell-derived allografts necessary maintaining long-term graft persistence. To model this alloimmunity, humanized mice engrafted with hematopoietic cells could prove be useful. In study, in-depth analysis graft-infiltrating lymphocytes splenocytes revealed that incompletely toward allogeneic their...
Severe trauma such as burn injury is often associated with a systemic inflammatory syndrome characterized by hyperactive innate immune response and suppressed adaptive function. Dendritic cells (DCs), which sense pathogens via their Toll-like receptors (TLRs), play pivotal role in protecting the host against infections. The effect of on TLR-mediated DC function debated topic mechanism controlling purported immunosuppressive remains to be elucidated. Here we examined effects splenic...
The objective of this study was to characterize a large portion the bovine neutrophil transcriptome following treatment with anti-inflammatory glucocorticoid dexamethasone (Dex). Total RNA isolated from blood neutrophils healthy cattle (5 castrated male Holsteins) immediately cell purification (0 h) or after ex vivo aging for 4 h without added Dex. Additional were cotreated receptor (GR) antagonist (RU486) and Dex h. amplified, dye labeled (Cy3 Cy5), hybridized series National Bovine...