A5060783496- Hematopoietic Stem Cell Transplantation
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Immunotherapy and Immune Responses
- Renal Transplantation Outcomes and Treatments
- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- CAR-T cell therapy research
- Polyomavirus and related diseases
- Mesenchymal stem cell research
- Childhood Cancer Survivors' Quality of Life
- Cytomegalovirus and herpesvirus research
- Lymphoma Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Immunodeficiency and Autoimmune Disorders
- Transplantation: Methods and Outcomes
- Histone Deacetylase Inhibitors Research
- Hematological disorders and diagnostics
- Neutropenia and Cancer Infections
- Eosinophilic Disorders and Syndromes
- Monoclonal and Polyclonal Antibodies Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Moffitt Cancer Center
2016-2025
University of South Florida
2012-2023
AdventHealth Tampa
2018
Northside Hospital
2017
Johns Hopkins Hospital
2017
Florida College
2013-2015
Medical College of Wisconsin
2004-2014
Virginia Commonwealth University Medical Center
2014
Georgetown University
2014
Bladder Cancer Advocacy Network
2014
Randomized trials have shown that the transplantation of filgrastim-mobilized peripheral-blood stem cells from HLA-identical siblings accelerates engraftment but increases risks acute and chronic graft-versus-host disease (GVHD), as compared with bone marrow. Some studies also are associated a decreased rate relapse improved survival among recipients high-risk leukemia.
T cell costimulation by molecules on the antigen presenting (APC) is required for optimal proliferation. The B7 molecule APC binds lymphocyte receptor CD28, triggering increased interleukin 2 (IL-2) production and subsequent CTLA-4 a predicted membrane homologous to which also counter receptor, but whose distribution function are unknown. Here we have developed monoclonal antibodies (mAbs) specific investigated these questions. mAbs were produced that bound not blocked binding of B7....
Chronic myeloid leukemia can be cured by marrow transplantation from an HLA-identical sibling donor. The use of transplants unrelated donors is option for the 70 percent patients without sibling, but morbidity and mortality associated with such have been cause concern. We analyzed safety efficacy treatment chronic identified variables that predict a favorable outcome.
The specificity of T lymphocyte activation is determined by engagement the cell receptor (TCR) peptide/major histocompatibility complexes expressed on antigen-presenting (APC). Lacking costimulation accessory molecules APC, proliferation does not occur and unresponsiveness to subsequent antigenic stimulus induced. B7/BB1 APCs binds CD28 CTLA-4 cells, provides a costimulus for proliferation. Here, we show that prolonged, specific hyporesponsiveness restimulation achieved blocking interaction...
Abstract We have previously shown that NKG2C+ NK cells from CMV naive umbilical cord blood grafts expand preferentially in recipients after reactivation, representing a primary cell response hematopoietic transplantation. In this study, of adult donor transplantation were assessed to evaluate the role donor/recipient serostatus on expression and function determine responses secondary events. Expansion was seen following clinical reactivation. However, they also expanded absence detectable...