A5011838093- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- T-cell and B-cell Immunology
- Renal Transplantation Outcomes and Treatments
- Immune Cell Function and Interaction
- Multiple Myeloma Research and Treatments
- Polyomavirus and related diseases
- CAR-T cell therapy research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Childhood Cancer Survivors' Quality of Life
- Immunotherapy and Immune Responses
- Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Oral health in cancer treatment
- COVID-19 and healthcare impacts
- Neutropenia and Cancer Infections
- Head and Neck Cancer Studies
- SARS-CoV-2 and COVID-19 Research
- Cancer Genomics and Diagnostics
- Respiratory viral infections research
- Cell Adhesion Molecules Research
- Cancer survivorship and care
- Cytomegalovirus and herpesvirus research
Virginia Commonwealth University
2016-2025
VCU Massey Comprehensive Cancer Center
2010-2024
University of Florida
2024
Virginia Cancer Institute
2011-2024
Virginia Commonwealth University Medical Center
2004-2023
University Health System
2014-2019
University of Richmond
2014
Children's Hospital of Richmond at VCU
2014
University of Alabama at Birmingham
2014
Georgetown University
2014
Oral mucositis is a complication of intensive chemotherapy and radiotherapy with no effective treatment. We tested the ability palifermin (recombinant human keratinocyte growth factor) to decrease oral mucosal injury induced by cytotoxic therapy.This double-blind study compared effect that placebo on development in 212 patients hematologic cancers; 106 received (60 microg per kilogram body weight day) intravenously for three consecutive days immediately before initiation conditioning therapy...
Randomized trials have shown that the transplantation of filgrastim-mobilized peripheral-blood stem cells from HLA-identical siblings accelerates engraftment but increases risks acute and chronic graft-versus-host disease (GVHD), as compared with bone marrow. Some studies also are associated a decreased rate relapse improved survival among recipients high-risk leukemia.
Endothelial attachment is the initial step in leukocyte recruit- ment into developing atherosclerotic lesions.To determine whether vascular cell adhesion molecule-i (VCAM-1) expres- sion may play a role inflammatory recruitment hu- man lesions, immunohistochemistry was performed with polyclonal rabbit antisera, raised against recom- binant human VCAM-1, on 24 coronary plaques and 11 control segments nonatherosclerotic diffuse intimal thickening from 10 patients.Immunophe- notyping adjacent...
Purpose This study evaluates the safety and efficacy of plerixafor (AMD3100), a CXCR4 antagonist, in mobilizing hematopoietic stem cells for autologous stem-cell transplantation non-Hodgkin's lymphoma (NHL) patients. Patients Methods is phase III, multicenter, randomized (1:1), double-blind, placebo-controlled study. with requiring an first or second complete partial remission were eligible. received granulocyte colony-stimulating factor (G-CSF; 10 μg/kg) subcutaneously daily up to 8 days....
Hematopoietic cell transplantation (HCT) is curative for hematologic disorders, but outcomes are historically inferior when using HLA-mismatched donors. Despite unrelated donor registries listing > 38 million volunteers, 25%-80% of US patients lack an HLA-matched donor, with significant disparity across ethnic groups. We hypothesized that HCT a mismatched (MMUD) post-transplant cyclophosphamide (PTCy), novel strategy successful in overcoming genetic related donors, would be feasible and...
The development of megakaryocytes (MKs) from their marrow precursors is one the least understood aspects hematopoiesis. Current models suggest that early-acting MK colony-stimulating factors, such as interleukin (IL) 3 or c-kit ligand, are required for expansion hematopoietic progenitors into cells capable responding to late-acting potentiators, including IL-6 and IL-11. Recently, Mp1 thrombopoietin (Tpo), has been shown display both factor potentiator activities, at potencies far greater...
Allogeneic stem cell transplantation is the standard approach to Philadelphia chromosome positive acute lymphoblastic leukemia. We hypothesized that imatinib plus sequential chemotherapy will result in significant leukemia cytoreduction patients with leukemia, allowing collection of normal hematopoietic cells uncontaminated by residual BCR/ABL1+ lymphoblasts and thus reduce likelihood relapse after autologous for under 60 years age without sibling donors. enrolled 58 patients; 19 underwent...
To characterize relationships between specific immune cell subsets in bone marrow (BM) or granulocyte colony-stimulating factor-mobilized peripheral blood (PB) stem cells collected from unrelated donors and clinical outcomes of patients undergoing transplantation BMTCTN 0201.Fresh aliquots 161 BM 147 PB stem-cell allografts North American randomly assigned to donate numbers transplanted were correlated with overall survival (OS), relapse, graft-versus-host disease (GvHD).Patients evaluable...
The use of post-transplantation cyclophosphamide (PTCy) as graft-versus-host disease (GVHD) prophylaxis has resulted in reductions GVHD and improved outcomes allogeneic hematopoietic cell transplantation (HCT) using HLA-mismatched related donors. We report the 3-year first multicenter prospective clinical trial PTCy setting mismatched unrelated donor (MMUD) bone marrow HCT. study enrolled 80 patients, treated with either myeloablative conditioning (MAC; n = 40) or reduced-intensity (RIC;...
Abstract Background The optimal timing of vaccination with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines after cellular therapy is incompletely understood. objectives this study are to determine whether humoral and responses SARS-CoV-2 differ if initiated <4 months versus 4–12 therapy. Methods We conducted a multicenter, prospective, observational at 30 cancer centers in the United States. was administered as part routine care. obtained blood prior vaccinations...
In a phase 3 multicenter, randomized, double-blinded, placebo-controlled study of 298 patients with non-Hodgkin lymphoma (NHL), granulocyte colony-stimulating factor (G-CSF) plus plerixafor increased the proportion who mobilized >or=5 x 10(6) CD34(+) hematopoietic stem cells (HSCs)/kg compared placebo G-CSF (P < .001). Patients in either arm failed mobilization (< 0.8 cells/kg 2 collections or <2 4 collections) were eligible to enter opened-label rescue protocol. Following 7-day minimum rest...
Cancer and Leukemia Group B conducted a phase II study to evaluate the safety efficacy of reduced-intensity conditioning regimen with allogeneic transplantation treat patients recurrent low-grade cell malignancies. Patients over age 18 diagnosis relapsed, chemotherapy-sensitive disease underwent matched sibling donor, cyclophosphamide (1 g/m(2)/day × 3) fludarabine phosphate (25 mg/m(2)/day 5). Graft-versus-host prophylaxis included cyclosporine or tacrolimus plus low-dose methotrexate....
The purpose of this report is to analyze long-term clinical outcomes patients exposed plerixafor plus granulocyte colony-stimulating factor (G-CSF) for stem cell mobilization. This was a study with non-Hodgkin lymphoma (NHL; n = 167) and multiple myeloma (MM; 163) who were enrolled in the follow-up 2 pivotal phase III studies (NCT00741325 NCT00741780) 240 µg/kg 10 G-CSF, or placebo G-CSF mobilize collect CD34+ cells autologous hematopoietic transplantation. Overall survival (OS)...
Allogeneic hematopoietic cell transplantation (allo-HCT) is potentially curative for older adults with hematologic malignancies. Concerns about non-relapse mortality (NRM) in limit allo-HCT utilization. We executed a prospective, observational study (BMT-CTN 1704) enrolling recipients aged ≥60 years from 49 centers the U.S. analyzed associations between 13 measurements of adult health and NRM within 1-year to construct comprehensive assessment risk model (primary-CHARM) using amultivariate...
ABSTRACT Although recent studies have demonstrated the efficacy of chimeric antigen receptor T‐cell (CAR‐T) therapy in relapsed large B‐cell lymphoma (LBCL) with MYC rearrangement (R‐MYC), data comparing CAR‐T to autologous hematopoietic cell transplant (auto‐HCT) such patients who achieve a complete or partial response (CR/PR) after salvage therapies are limited. We compared clinical outcomes R‐MYC LBCL (including double and triple hit lymphomas) underwent auto‐HCT achieving CR/PR using...
Coccidioidomycosis is a spectrum of diseases caused by the dimorphic fungi Coccidioides. Current regimens for severe or disseminated disease include fluconazole, itraconazole, amphotericin; newer triazoles (ie, voriconazole, posaconazole) have been demonstrated to be useful in refractory disease. Previous reported experience with combination triazole and caspofungin therapy has very limited; however, utility this treatment other invasive fungal suggests potential benefit...
Summary Patients with multiple myeloma ( MM ) undergoing high dose therapy and autologous stem cell transplantation SCT remain at risk for disease progression. Induction of the expression highly immunogenic cancer testis antigens CTA in malignant plasma cells patients may trigger a protective immune response following . We initiated phase II clinical trial DNA hypomethylating agent, azacitidine A za) administered sequentially lenalidomide (Rev) Three cycles za R ev were lymphocytes collected...