A5076296458- Multiple Myeloma Research and Treatments
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Protein Degradation and Inhibitors
- Hematopoietic Stem Cell Transplantation
- vaccines and immunoinformatics approaches
- Acute Lymphoblastic Leukemia research
- Cancer Treatment and Pharmacology
- Childhood Cancer Survivors' Quality of Life
- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Treatment and Research
- Adolescent and Pediatric Healthcare
- Corneal surgery and disorders
- Mesenchymal stem cell research
- Transplantation: Methods and Outcomes
- Neutropenia and Cancer Infections
- T-cell and B-cell Immunology
- Paraoxonase enzyme and polymorphisms
- Coenzyme Q10 studies and effects
- Pancreatic and Hepatic Oncology Research
- Biochemical Acid Research Studies
- Sepsis Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Ocular Surface and Contact Lens
- Antifungal resistance and susceptibility
First People's Hospital of Nanning
2024
Hangzhou Medical College
2023
Zhejiang Provincial People's Hospital
2023
Emmes (United States)
2010-2023
Shanghai Children's Medical Center
2020-2023
Shanghai Jiao Tong University
2020-2023
Chengdu University of Traditional Chinese Medicine
2021
University of Alabama at Birmingham
2014
Medical College of Wisconsin
2014
Alkermes (Ireland)
2014
To characterize relationships between specific immune cell subsets in bone marrow (BM) or granulocyte colony-stimulating factor-mobilized peripheral blood (PB) stem cells collected from unrelated donors and clinical outcomes of patients undergoing transplantation BMTCTN 0201.Fresh aliquots 161 BM 147 PB stem-cell allografts North American randomly assigned to donate numbers transplanted were correlated with overall survival (OS), relapse, graft-versus-host disease (GvHD).Patients evaluable...
While the association between decreased serum albumin (ALB) levels and increased risk of acute kidney injury (AKI) is well established, death among patients with AKI low ALB unclear. We aimed to evaluate in mortality, help guide their clinical management.The included were those diagnosed admitted Zhejiang Provincial People's Hospital January 2018 December 2020. The endpoint was all-cause mortality rate at 90-days 1-year. Patients divided into four groups according quartiles (Qs) measurements...
Abstract Purpose: Vaccination with dendritic cell (DC)/multiple myeloma (MM) fusions has been shown to induce the expansion of circulating multiple myeloma–reactive lymphocytes and consolidation clinical response following autologous hematopoietic transplant (auto-HCT). Patients Methods: In this randomized phase II trial (NCT02728102), we assessed effect DC/MM fusion vaccination, GM-CSF, lenalidomide maintenance as compared control arms GM-CSF or alone on rates induction myeloma–specific...
Dry eye is a common disease. Artificial tears supplements are widely used for the treatment of dry eyes. However, multiple adverse effects have been observed in patients receiving long-term with artificial tears, which may affect therapeutic effect.
Amphiregulin (AREG) is an epidermal growth factor receptor ligand that can restore integrity to damaged intestinal mucosa in murine models of acute graft-versus-host disease (aGVHD). We previously reported circulating AREG elevated late-onset aGVHD (occurring after 100 days posttransplant), but its clinical relevance the context risk unknown. measured 251 onset blood samples from Blood and Marrow Clinical Trials Network (BMT CTN) primary treatment trials determined their association with...
Abstract Elevated AR expression or mutations in tumor cells, causing resistance to first generation antagonist agents, are considered the main driver of castration resistant prostate cancer (CRPC). MDV3100, a more potent ( 5x vs bicalutamide) without residual agonism, has demonstrated excellent efficacy CRPC patients and been approved by FDA for treating clinic. More recently, antagonists anti-tumor activities preclinical AR+ breast models being tested clinical trials. Although MDV3100 is...
This study aimed to investigate the correlation of L-asparaginase (L-asp) activity, anti-L-asp antibody, asparagine and glutamine levels with risks adverse events (AEs), especially anaphylaxis, in pediatric acute lymphoblastic leukemia (ALL) patients who underwent polyethylene glycol-conjugated L-asp (PEG-asp)-contained treatment.Plasma samples were collected from 91 ALL PEG-asp-contained treatment on 7th day after drug administration. Plasma antibody level, level detected. Meanwhile, AEs...
<p>Study representation of underserved communities</p>
<p>Supplemental Figure 1: (A) Progression Free Survival Kaplan Meier Curve. (B) Overall Curve.</p>
<p>Study representation of underserved communities</p>
<p>Supplemental Figure 1: (A) Progression Free Survival Kaplan Meier Curve. (B) Overall Curve.</p>
<div>Abstract<p>Purpose: Vaccination with dendritic cell (DC)/multiple myeloma (MM) fusions has been shown to induce the expansion of circulating MM-reactive lymphocytes and consolidation clinical response following autologous hematopoietic transplant (autoHCT). Patients Methods: In this randomized phase II trial (NCT02728102), we assessed effect DC/MM fusion vaccination, GM-CSF, lenalidomide maintenance as compared control arms GM-CSF or alone on rates induction MM-specific...
Abstract Androgen Receptor (AR) antagonists have been used in clinic to treat prostate cancer. One example is bicalutamide (Casodex®), which along with castration advanced Unfortunately, the patients developed resistance (alone or combination therapy) after only 0.5-2 years of treatment, resulting castration-resistant cancer (CRPC). Elevated AR expression tumor cells correlates a change functional activity from antagonist agonist, suggesting that tumors may adapt survive on any residual...
Mycophenolate mofetil (MMF) is a common and effective prophylactic immune suppressant that promotes hematopoietic cell engraftment prevents graft vs host disease (GVHD) after allogeneic stem transplant (HCT). However, there limited data as to the effectiveness of MMF plus high dose corticosteroids for treatment acute GVHD even less regarding pharmacokinetic disposition exposure-response relationship mycophenolate in individuals with GVHD. pharmacokinetics were studied multi-center CTN...
In the assay of serum PON arylesterase activity using phenyl acetate as a substrate, number other hydrolases can catalyze substrate hydrolysis, and so bring high background signal. EDTA 2-hydroxyquinoline (2-HQ) were inhibitors. Based on this property, be determined by adding or 2-HQ just prior to (phenyl acetate). The specific was obtained subtracting from total activity. correlation signals based different inhibitors investigated, respectively. inhibition consistency analyzed. analysis...
<p>Study representation of underserved communities</p>
<p>Study representation of underserved communities</p>
<p>Supplemental Figure 1: (A) Progression Free Survival Kaplan Meier Curve. (B) Overall Curve.</p>