A5100362415- Nanoparticle-Based Drug Delivery
- Crystallization and Solubility Studies
- RNA Interference and Gene Delivery
- Drug Solubulity and Delivery Systems
- Aortic Disease and Treatment Approaches
- Advanced biosensing and bioanalysis techniques
- Aortic aneurysm repair treatments
- Cancer-related Molecular Pathways
- X-ray Diffraction in Crystallography
- Advanced Drug Delivery Systems
- Nanoplatforms for cancer theranostics
- Infectious Aortic and Vascular Conditions
- Adaptive Control of Nonlinear Systems
- Lung Cancer Treatments and Mutations
- Radiopharmaceutical Chemistry and Applications
- DNA Repair Mechanisms
- Cardiac Valve Diseases and Treatments
- Lanthanide and Transition Metal Complexes
- Prostate Cancer Treatment and Research
- Dendrimers and Hyperbranched Polymers
- Ferroptosis and cancer prognosis
- Sulfur Compounds in Biology
- Stability and Control of Uncertain Systems
- Click Chemistry and Applications
- Glycosylation and Glycoproteins Research
Shanxi Agricultural University
2025
First Affiliated Hospital of Soochow University
2024
Soochow University
2024
Zhuhai Institute of Advanced Technology
2023
Jilin University
2023
First Affiliated Hospital of Xi'an Jiaotong University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2022
Peking University
2013-2022
Peking University Third Hospital
2022
Purdue University West Lafayette
2016-2021
Crystal growth from amorphous drugs is of interest in the context solubility enhancing formulations. Herein, impact polymers on crystal different polymorphs undercooled liquid was investigated using indomethacin (IDM) as a model compound and hydroxypropyl methylcellulose (HPMC), acetate succinate (HPMCAS), polyvinylpyrrolidone (PVP) polymeric inhibitors. Samples sandwiched between two coverslips were prepared by melt quenching, identified Raman spectroscopy, hot stage microscopy, X-ray...
The fluorescent vesicles based on lanthanide ions are considered as an ideal biomimetic optical nanoplatform for simulating biological processes of cell membrane. However, the accurately and controllably adjusting size lanthanides while ensuring their fluorescence performance stability still remains a challenge. Herein, dual-stimuli-responsive supramolecular vesicle with tunable has been designed host-guest interaction coordinating aggregation. Europium complexes can be encapsulated within...
Lung cancer, a disease related mostly to tobacco smoke exposure and leading cause of cancer-related death in industrialized countries, is frequently associated with mutations the p53 tumor suppressor gene. Genetic differences resulting inter-individual variation DNA repair capacity may part account for susceptibility cell genotoxic agents somatic mutations, including eventual transformation normal into malignant phenotype. The objective this study investigate relationship between...
We demonstrate the use of modeling and simulation to investigate bioequivalence (BE) concerns raised about generic warfarin products. To test hypothesis that loss isopropyl alcohol slow dissolution in acidic pH has significant impact on pharmacokinetics sodium tablets, we conducted physiologically based pharmacokinetic absorption using formulation factors or vitro profiles as input parameters. Sensitivity analyses indicated was not sensitive solubility, particle size, density, rate 4.5, but...
Garlic oil is a liquid extracted from garlic that has various natural antibacterial and anti-inflammatory properties believed to be used prevent treat many diseases. However, the main functional components of are unstable. Therefore, in this study, encapsulating with cyclodextrin using saturated co-precipitation method can effectively improve its chemical stability water solubility reduce characteristic odor taste. After preparation, microcapsules were characterized, which proved...
Study on the processes of thiol-mediated disulfide exchange reactions cell surface is not only important to our understanding extracellular natural bioreduction but development novel strategies for intracellular delivery synthetic bioactive molecules. However, disulfide-bonded probes have their intrinsic inferiority in exploring detailed pathway because bidirectional reactivity bonds toward reactive thiols. In this work, we developed thioether-bonded fluorescent that enable us explore...
Tetrahydroisoquinoline (THIQ) scaffolds are important structural units that widely exist in a variety of natural alkaloids and synthetic analogues. Asymmetric synthesis C1-chiral THIQ is particular importance due to its significant pharmaceutical, agrochemical, other biological activities, the usually distinct bioactivities exhibited by two enantiomers. In this review, we highlight advances achieved field, present recent asymmetric with imines isoquinoline rings ordered according sequence...
Mutations in the K- ras gene are very common lung tumours and implicated development of cancer, but timing their occurrence remains poorly understood. We investigated mutations cell samples microdissected by laser capture microscopy at multiple sites from tissue sections representing tumour matched histologically normal obtained 48 cancer patients. were detected 10 38 (26.3%) adenocarcinomas none or taken squamous carcinomas. Of mutation-positive adenocarcinomas, 4 cases a mutation was found...
Abstract Elevated AR expression or mutations in tumor cells, causing resistance to first generation antagonist agents, are considered the main driver of castration resistant prostate cancer (CRPC). MDV3100, a more potent ( 5x vs bicalutamide) without residual agonism, has demonstrated excellent efficacy CRPC patients and been approved by FDA for treating clinic. More recently, antagonists anti-tumor activities preclinical AR+ breast models being tested clinical trials. Although MDV3100 is...
In this study, we use cytarabine anticancer drug to synthesize a new rare earth complex with Europium ion. The study work is an attempt investigate luminescence and biological properties of the Eu-based coordination polymers (Eu-CP-Ara) which have been prepared by us. Eu-CP-Ara has emission centering at about 619 nm excited 394 nm. We in vitro cytotoxicity. Cytotoxicity against lung cancer cells (A549) could even be comparable inhibitory effect ligands, showing advantage antitumor activity....