A5100711574- Epigenetics and DNA Methylation
- Ocular Oncology and Treatments
- Prostate Cancer Treatment and Research
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- interferon and immune responses
- Acute Myeloid Leukemia Research
- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Catalytic Processes in Materials Science
- Cell Adhesion Molecules Research
- Retinal Imaging and Analysis
- Industrial Gas Emission Control
- Advanced Glycation End Products research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Vascular Tumors and Angiosarcomas
- Electrocatalysts for Energy Conversion
- Cancer-related molecular mechanisms research
- CNS Lymphoma Diagnosis and Treatment
- Optical Coherence Tomography Applications
- NF-κB Signaling Pathways
- Vascular Malformations and Hemangiomas
- Delphi Technique in Research
- Synthesis and Biological Evaluation
Qilu Hospital of Shandong University
2011-2025
First Hospital of China Medical University
2021-2024
China Medical University
2021-2024
Nanjing University of Chinese Medicine
2022-2024
Shanghai Clinical Research Center
2023
Shandong University
2013-2023
Andre Abrasive Articles (Poland)
2016
Shanghai Xuhui Central Hospital
2012
DNA methyltransferases (DNMTs) 1, 3a, and 3b affect promoter methylation; studies have suggested that they important roles in the development of cancers. In this study, we analyzed expression DNMTs 3b; MIB-1 labeling index; their clinical significance 6 normal retinas 62 retinoblastomas using immunohistochemical analysis. We found DNMT proteins were not expressed retinas, whereas frequently (DNMT1, 100%; DNMT3a, 98%; DNMT3b, 92%). Compared with well-differentiated retinoblastomas, 1 3a...
This study was designed to investigate the association between polymorphisms in three insulin resistance-related genes, uncoupling protein-1 (UCP1), peroxisome proliferator-activated receptor γ (PPARγ) and transcription factor 7-like 2 (TCF7L2) susceptibility diabetic retinopathy (DR) a Chinese type diabetes mellitus (T2DM) cohort. A total of 792 patients with T2DM were enrolled categorized into two groups: (1) DR group consisted 448 patients, which further subclassified proliferative (PDR)...
To analyze the prognostic value and potential target for therapeutic intervention of enhancer zeste homologue 2 (EZH2) in uveal melanomas (UM) patients.We analyzed EZH2 expression 89 primary UM patients by immuno- histochemistry to observe clinicopathological EZH2.The high levels mitoses count Ki67 labeling index had significant correlation with overexpression (R = 0.408, P.Our critical finding is that can be served as predictive marker associated adverse clinical outcomes. Further...
Background Currently, cytogenetic and genetic markers are the most important for risk stratification treatment of patients with acute myeloid leukemia (AML). Despite identification many prognostic factors, relatively few have made their way into clinical practice. Therefore, new AML biomarkers is useful in prognosis monitoring contributes to a better understanding molecular basis disease. Homeobox (HOX) genes transcription factors that lead cell differentiation blockade malignant...
There is increasing evidence that the high mobility group A1 (HMGA1) protein, which functions as a transcriptional master regulator, plays critical roles in tumor progression. We evaluated HMGA1 expression 89 primary uveal melanomas (UM) by immunohistochemistry to determine clinicopathological and prognostic value of UM after adjusting for other variables. Nuclear was detected 44% UMs. High levels were more frequent UMs with epithelioid cell pattern, mitoses count, Ki67 labeling index (P =...
ABSTRACTPurpose: To evaluate the association of intercellular cell-adhesion molecule 1 (ICAM-1) and high-mobility group A1 (HMGA1) gene variants with diabetic retinopathy (DR) in a Chinese type 2 diabetes mellitus (T2DM) cohort.Methods: A total 792 patients T2DM were enrolled categorized into two groups: (1) DR consisted 448 patients, which was further subclassified proliferative (PDR) 220 nonproliferative (NPDR) 228 patients; (2) without (DNR) comprised 344 who had no signs DR. The...
Aims The nuclear factor-κB (NF-κB) transcription factors family is thought to play an important role in the development of certain cancers. In this study, clinical significance NF-κB factor expression and MIB-1 labelling index (MIB-1 LI) were studied retinoblastoma. Methods Immunohistochemical analysis normal retina (n=6) retinoblastoma tumour (n=62) specimens obtained from multiple centres was performed order evaluate pathological associations subunits Results Expression proteins frequently...
Patients with NPM1 gene mutation-associated acute myeloid leukemia (AML), particularly those over the age of 60, have no viable targeted therapeutic choices. In this study, we identified HEN-463, a sesquiterpene lactone derivative specific targets AML mutation. This compound inhibits interaction LAS1-NOL9 by covalently binding to C264 site ribosomal biogenesis-related protein LAS1, which translocates LAS1 cytoplasm, thereby inhibiting maturation 28 S rRNA. has profound effect on...
The emergence of anti-vascular endothelial growth factor (anti-VEGF) therapy has revolutionized neovascular age-related macular degeneration (nAMD). Post-therapeutic optical coherence tomography (OCT) imaging facilitates the prediction therapeutic response to anti-VEGF for nAMD. Although generative adversarial network (GAN) is a popular model post-therapeutic OCT image generation, it realistically challenging gather sufficient pre- and pairs, resulting in overfitting. Moreover, available...
Although NPM1 mutations are frequently found in acute myeloid leukemia patients, therapeutic strategies scarce and unsuitable for those who cannot tolerate intensive chemotherapy. Here we demonstrated that heliangin, a natural sesquiterpene lactone, exerts favorable responses mutant cells, with no apparent toxicity to normal hematogenous by inhibiting their proliferation, inducing apoptosis, causing cell cycle arrest, promoting differentiation. In-depth studies on its mode of action using...
H2O2 is an important green oxidant, and activation of the key process determining its efficiency in removing environmental pollutants. However, due to complex catalytic sites diverse...