A5100416198- Acute Lymphoblastic Leukemia research
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- Signaling Pathways in Disease
- Liver Disease Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- S100 Proteins and Annexins
- Cancer Mechanisms and Therapy
- CAR-T cell therapy research
- Chromatin Remodeling and Cancer
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Cell Adhesion Molecules Research
- Cytokine Signaling Pathways and Interactions
- Retinoids in leukemia and cellular processes
- Lung Cancer Research Studies
- Blood Pressure and Hypertension Studies
- Chronic Lymphocytic Leukemia Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Spine and Intervertebral Disc Pathology
- Cardiac Fibrosis and Remodeling
Hunan City University
2025
Hunan University
2025
First Hospital of Jilin University
2022-2024
Jilin University
2022-2024
Peking University
2019-2023
China Medical University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2023
Peking University People's Hospital
2019-2023
Shanghai Institutes for Biological Sciences
2022-2023
Chinese Academy of Sciences
2022-2023
Background The purpose of this study is to develop an artificial intelligence (AI)-based automated diabetic retinopathy (DR) grading and training system from a real-world dataset China, in particular, investigate its effectiveness as learning tool DR manual for medical students. Methods We developed equipped with AI-driven diagnosis algorithm highlight highly prognostic related regions the input image. Less experienced prospective physicians received pre- post-training tests by AI platform....
Metagenomic next-generation sequencing (mNGS) is an emerging technique for pathogen detection. However, most literature on the clinical application of pediatrics generally comprises case reports or small-scale cohort studies.A total 101 children with community-acquired severe pneumonia admitted to Tianjin Children's Hospital from November 2021 February 2022 were included. Pathogens in bronchoalveolar lavage fluid (BALF) specimens detected using mNGS. The performances mNGS and conventional...
The objective of this study was to investigate the therapeutic effect Wuqinxi Qigong vs. stretching on single- and dual-task gait, motor symptoms, quality life in people with mild moderate Parkinson’s disease (PD). This single-blind, randomized control trial included 40 participants idiopathic PD who were into (WQ) group or group. Participants completed 12 weeks (two sessions/week) intervention. primary outcomes gait parameters when performing single-task (comfortable pace) (obstacle...
Background: COVID-19 displays an increased mortality rate and higher risk of severe symptoms with increasing age, which is thought to be a result the compromised immunity elderly patients. However, underlying mechanisms aging-associated immunodeficiency against Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains unclear. Epigenetic modifications show considerable changes causing altered gene regulations cell functions during aging process. The DNA methylation patterns among...
This cohort study aimed to identify the characteristics and risk factors of adult idiopathic inflammatory myopathy-associated interstitial lung disease (IIM-ILD) further explore prognostic IIM-ILD. We extracted data regarding 539 patients with laboratory-confirmed myopathy (IIM) or without (ILD) from Second Xiangya Hospital Central South University between January 2016 December 2021. The regression analysis was conducted possible for ILD as well mortality. Of IIM patients, 343 (64.6%) were...
To translate and test the psychometric properties of a Chinese version scale to measure Fear Activity in patients with Coronary Artery Disease.A cross-sectional design.The translation Patients Disease included three steps, forward-back translation, expert discussion pilot survey. The internal consistency test-retest reliability were used assess Activity. Content, construct, criterion, known-group validity also evaluated.A total 275 recruited from university-affiliated hospital Guangzhou,...
Plexiform fibromyxoma (PF) is a rare mesenchymal tumor of which the pathogenesis and molecular changes are still unclear. Histologically, it characterized by cluster bland spindle or ovoid cells growing in mucoid fibromyxoid stroma rich small blood vessels. At present, surgical resection primary treatment for PF.
Ferroptosis-inducing agents (FIAs) induced lipid-peroxidation-independent ferroptosis in eosinophils, thus ameliorating airway inflammation asthmatic mice. Differences ferroptosis-related genes (FerrGs) between eosinophils and cells which FIAs induce canonical are supposed to contribute this noncanonical but remain unclear. This study aims explore these differences. used gastric cancer (GCCs) stomach adenocarcinoma as the representative of ferroptosis. FerrGs Ferroptosis Database V2...
TPS1124 Background: Targeting constitutively active mutant kinases with selective small molecule inhibitors is a key therapeutic pillar of precision oncology. Phosphatidylinositol-4,5bisphosphate-3 kinase, catalytic subunit alpha ( PIK3CA) mutations leading to oncogenic activation PI3Kα represent the largest opportunity for this approach in solid tumors. However, there no inhibitor that targets clinic. Toxicity related non-selective inhibition WT (hyperglycemia) and other PI3K isoforms...
This study aimed to explore the application of Yb(OH)CO3 nanoparticles in prediction model computed tomography (CT) contrast lung biopsy pneumothorax (LBP) by synthesizing a new type nanoparticles, which provides basis for clinical application. were prepared homogeneous precipitation process based on urea, and samples characterized scanning electron microscopy (SEM) transmission (TEM). Methyl thiazolyl tetrazolium (MTT) assay was adopted vitro cytotoxicity test, optical density (OD) value...
Objective: To investigate the distribution, epidemiology, and clinical symptoms of brucellosis Q fever in northeastern Inner Mongolia. Methods: In this study, 64 townships Bairin left flag Alukerqin flag, Jarud Horqin right front four counties with frequent were selected. Epidemiological characteristics, features, exposure to risk factors identified descriptively analyzed patients from these areas. Results: There 367 cases regions 78 positive Q-fever infection. addition, 24 co-infection...
Intravascular lithotripsy (IVL) is a novel clinical technique for the management of severely calcified lesions. However, biological effects shock wave on healthy arterial tissue have not been demonstrated. The preclinical safety study aimed to investigate vascular response IVL compared plain old balloon angioplasty (POBA) in porcine peripheral arteries.The left and right iliofemoral segments 16 mini-pigs were subjected POBA, respectively. was evaluated using quantitative angiography (QVA),...
Abstract Background Previous clinical data have shown that raltegravir-based antiretroviral therapy (ART) with fewer drug-drug interactions (DDIs) and adverse events (AEs) is a good regimen in patients HIV infection who need cancer chemotherapy. There are currently few on ART regimens include Integrase inhibitors (INSTIs) other than RAL among this patient subgroup. Methods We evaluated the safety efficacy of different kinds INSTI-based concomitant colorectal (CRC) received antineoplastic...
Although numerous clinical studies have reported that pulsed electromagnetic fields (PEMF) a neuroprotective role in patients with diabetic peripheral neuropathy (DPN), the application of PEMF for clinic is still controversial.The present study was designed to investigate whether has therapeutic potential relieving neuropathic symptoms streptozotocin (STZ)-induced rats.Adult male Sprague-Dawley rats were randomly divided into three weightmatched groups (eight each group): non-diabetic...
Objective: To study the correlation between risk factors, degree of vascular restenosis, and inflammatory factors after interventional treatment for stroke. Methods: The clinical data 96 stroke patients who received therapy in our hospital from April 2020 to June 2021 were selected retrospective study, postoperative follow-up was 1 year. Univariate multivariate regression used analyze identified associated with efficacy. At same time, value factor levels predicting restenosis analyzed....
To observe the clinical efficacy of acupuncture for prevention moderate to severe seasonal allergic rhinitis.A total 105 patients with rhinitis were randomly divided into an observation group (53 cases, 3 cases dropped off) and a control (52 4 off). The in treated at Yintang (GV 24+), Yingxiang (LI 20), Hegu 4), Zusanli (ST 36), Fengchi (GB Feishu (BL 13), etc. weeks before seizure period, once every other day, times week weeks. not given any intervention period. Emergency drugs can be...