A5071560112- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Extracellular vesicles in disease
- CAR-T cell therapy research
- HER2/EGFR in Cancer Research
- Genetic factors in colorectal cancer
- Acute Myocardial Infarction Research
- Radiopharmaceutical Chemistry and Applications
- Immune cells in cancer
- Cardiac Imaging and Diagnostics
- Cardiac Arrest and Resuscitation
- Lung Cancer Research Studies
- Gastric Cancer Management and Outcomes
- Peptidase Inhibition and Analysis
- Advanced biosensing and bioanalysis techniques
- Cancer-related Molecular Pathways
- Advanced X-ray and CT Imaging
- Immunotherapy and Immune Responses
- PI3K/AKT/mTOR signaling in cancer
Sarah Cannon
2021-2025
HealthONE
2021-2025
Sarah Cannon Research Institute
2023-2024
The University of Texas MD Anderson Cancer Center
2018-2024
Southeast Missouri State University
2024
RIKEN BioResource Research Center
2023
Minneapolis Heart Institute Foundation
2006-2020
Abbott Northwestern Hospital
2011-2020
Cedars-Sinai Medical Center
2019
University of Colorado Denver
2018
BackgroundColorectal cancer (CRC) has been shown to acquire RAS and EGFR ectodomain mutations as mechanisms of resistance epidermal growth factor receptor (EGFR) inhibition (anti-EGFR). After anti-EGFR withdrawal, mutant clones lack a advantage relative other decay; however, the kinetics decay remain unclear. We sought determine acquired RAS/EGFR after discontinuation therapy.Patients methodsWe present post-progression circulating tumor DNA (ctDNA) profiles 135 patients with RAS/BRAF...
Abstract Previous studies implicated protein arginine methyltransferase 5 (PRMT5) as a synthetic lethal target for MTAP-deleted (MTAP del) cancers; however, the pharmacologic characterization of small-molecule inhibitors that recapitulate phenotype has not been described. MRTX1719 selectively inhibited PRMT5 in presence MTA, which is elevated MTAP del cancers, and PRMT5-dependent activity cell viability with >70-fold selectivity HCT116 compared wild-type (WT) cells. demonstrated...
p.G12C mutations occur in approximately 3% of metastatic colorectal cancers (mCRC). Recently, two allosteric inhibitors
Abstract Longitudinal monitoring of patients with advanced cancers is crucial to evaluate both disease burden and treatment response. Current liquid biopsy approaches mostly rely on the detection DNA-based biomarkers. However, plasma RNA analysis can unleash tremendous opportunities for tumor state interrogation molecular subtyping. Through application deep learning algorithms deconvolved transcriptomes within extracellular vesicles (evRNA), we successfully predicted consensus subtypes in...
We report a case of patient with squamous cell carcinoma (SCC) who developed myasthenia gravis (MG), myositis, and myocarditis after receiving cemiplimab, an anti-PD-1 immune checkpoint inhibitor (ICI). Case Presentation. An 86-year-old man metastatic periocular SCC presented decreased vision in the left eye, severe fatigue, lower back bilateral hip pain 3 weeks cemiplimab. Within hours, he dysphonia, pharyngeal secretions, dysphagia, necessitating intubation. Endomyocardial biopsy revealed...
Introduction Leptoids, the food-conducting cells of polytrichaceous mosses, share key structural features with sieve elements in tracheophytes, including an elongated shape oblique end walls containing modified plasmodesmata or pores. In callose is instrumental developing pores that enable efficient photoassimilate transport. Aside from a few studies using aniline blue fluorescence yielded confusing results, little known about moss leptoids. Methods Callose location and abundance during...
286 Background: Constitutive activation of ß-catenin, resulting in its nuclear accumulation and deregulated transcriptional activity, is a key event colorectal cancer (CRC). Additionally, pathway mutations correlate with immune exclusion CRC across different tumor types. Disruption the interaction ß-catenin co-activator BCL9 sufficient to suppress oncogenic without impacting homeostatic functions normal tissue. ST316 first-in-class, cell-penetrating peptide antagonist interaction....
Stearoyl-acyl carrier protein desaturase (SACPD-C) has been reported to control the accumulation of seed stearic acid; however, no study previously its involvement in leaf acid content and impact on structure morphology. A subset an ethyl methanesulfonate mutagenized population soybean (Glycine max) 'Forrest' was screened identify mutants within GmSACPD-C gene. Using a forward genetics approach, one nonsense four missense Gmsacpd-c were identified have high levels seed, nodule, content....
2529 Background: Activation of T cells in the tumor microenvironment by 4-1BB agonist antibodies is a promising approach to augment PD-(L)1 inhibitor efficacy. Ragistomig(ABL503/TJ-L14B) bispecific antibody combining PD-L1 antagonist with agonistic activity, designed induce signaling only when bound antigen on cancer cells, which may overcome resistance inhibition and avoid hepatoxicity seen traditional mAbs. Methods: ABL503 was investigated at doses ranging from 0.7 mg (flat dose) 10 mg/kg...
Multislice CT coronary angiography (MSCTA) accurately detects stenosis in patients undergoing arteriography, but its accuracy clinical outpatients is less certain. This study retrospectively analyzed MSCTA performance a large outpatient cohort and examined 6-month follow-up those without invasive CA.Patients underwent for indications including symptoms or noninvasive results being either equivocal suspected as incorrect by referring clinicians. Standard 16-slice scanner techniques were used,...
TPS2690 Background: Tumor resistance to immune checkpoint inhibitors (CPIs), including pembrolizumab, is common. Suggested mechanisms of include reduced interferon (IFN) signaling, escape, and immunosuppressive tumor phenotypes. Innate cell stimulation in the microenvironment may be a potential pathway overcome this resistance. Stimulator genes (STING) cytosolic protein critical for initiation type-1 IFN-dependent innate immunity. TAK-500 novel ISAC comprising STING agonist (based on...
180 Background: RAS mutations are found in ~50% of patients (pts) with metastatic colorectal cancer (mCRC) and associated resistance to anti-EGFR. Circulating tumor DNA (ctDNA) enables detection resistant MUT arising from WT . Recently there has been interest defining the converse: tumors that revert , early results suggesting rates ~7%. Clinical trials this population development, though incidence not validated robust methodologies. Methods: 1) We identified 74 mCRC pts baseline...
The purpose of this study was to determine the effectiveness computer-assisted instruction (CAI) teach anatomy, biomechanics, and pathomechanics temporomandibular joint (TMJ). Sixty-six first- second-year physical therapist students at Southwest Texas State University participated. None subjects had received on TMJ prior study. A two-group pretestposttest experimental design used. Each group consisted 18 first-year 15 students. control taught information by traditional lecture format using...
TPS9156 Background: The epidermal growth factor receptor (EGFR) is a potent oncogene commonly altered in many cancers, including glioblastoma (GBM) and non-small cell lung cancer (NSCLC). EGFR tyrosine kinase activity driven by common mutations can be inhibited small molecules, however, resistance to available agents may the active site or other regions. BDTX-1535 an orally available, highly potent, selective, irreversible inhibitor of mutations, extracellular variants amplifications...
Abstract BACKGROUND: Oncogenic activation of PI3Kα via mutation PIK3CA is the most common kinase driver event across solid tumors, particularly breast cancer (BC). Alpelisib, an orthosteric inhibitor, validated mutant-PI3Kα as a therapeutic target; however, toxicity from non-selective inhibition WT (hyperglycemia) and other PI3K isoforms limits its clinical activity. RLY-2608, novel oral allosteric designed to overcome these limitations mutant- isoform-selective inhibition. We initiated...
Multidetector-CT angiography (MDCTA) differs from noninvasive stress tests by directly imaging coronary anatomy. The utility of MDCTA for invasive triage is undefined however. We evaluated to in outpatients with indeterminate or suspected inaccurate tests, and estimated cost savings this role.Consecutive patients were retrospectively compared if performed within 6 months MDCTA. Twelve-month clinical follow up was obtained not undergoing angiography, using calculated.MDCTA 385 who had...
<h3>Background</h3> There is an urgent unmet medical need for patients with advanced unresectable and/or metastatic carcinomas. Mucin 1 (MUC1) a well-characterized heterodimeric glycoprotein that overexpressed on many epithelial-derived tumors and consists of non-covalently linked N-terminal (MUC1-N) C-terminal (MUC1-C) monomers. The MUC1-C epitope selectively seen in solid such as breast, colorectal, ovarian, gastric, lung carcinoma others. also expressed broadly accessibly throughout tumor...
3100 Background: Colony-stimulating factor 1 (CSF-1) pathway is involved in the development of various types cancer. Pimicotinib an orally available, selective, potent small molecule CSF-1R inhibitor with significant pre-clinical anti-tumor activity. Here we present results phase trial. Methods: The escalation part employed a 3+3 design starting dose 25 mg QD (28-day/ cycle) to determine maximum tolerated (MTD) and recommended for expansion (RDE). Additional pts selected tumor including...
Abstract Epidermal growth factor receptor (EGFR) is a potent oncogene commonly altered in non-small cell lung cancer (NSCLC) and glioblastoma (r/rGBM). For NSCLC, EGFR tyrosine kinase activity can be driven by classical driver (L858R, Ex19del), intrinsic (atypical) (L718Q, L861Q, S768I), acquired resistance mutation (C797X). BDTX-1535 an oral, highly potent, brain penetrant, selective, irreversible 4th generation inhibitor that targets all 3 classes of mutations. Preliminary results from the...
Male gametes (spermatozoids) are the only motile cells produced during life cycle of land plants.While absent from flowering and most cone-bearing plants, found in less derived taxa, including bryophytes (mosses, liverworts hornworts), pteridophytes (lycophytes ferns) some seed plants (Ginkgo cycads).During development, these undergo profound changes that involve production a locomotory apparatus, unique microtubule (MT) arrays, series special cell walls sequence synchronized with cellular...
3514 Background: Colorectal cancers (CRC) lacking RAS MTs treated with EGFRi are thought to evolve by a repetitive process of genetic diversification and clonal evolution. Acquired in KRAS, NRAS, BRAF, MAP2K1, EGFR known mechanisms acquired resistance the refractory population. However, prevalence first line (1L) setting is not well established as most experience has been beyond 1L setting. Methods: We analyzed paired plasma samples from RAS/BRAF/EGFR WT mCRC patients (pts) enrolled 3 large...