A5051665479- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Traditional Chinese Medicine Studies
- MicroRNA in disease regulation
- RNA Research and Splicing
- Gastric Cancer Management and Outcomes
- Natural product bioactivities and synthesis
- Cancer Mechanisms and Therapy
- Cancer-related Molecular Pathways
- Lung Cancer Research Studies
- Bone health and treatments
- Bone Metabolism and Diseases
- Sarcoma Diagnosis and Treatment
- Forensic and Genetic Research
- Bone Tumor Diagnosis and Treatments
- Peptidase Inhibition and Analysis
- Medicinal Plant Pharmacodynamics Research
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Bone and Joint Diseases
Liaoning Cancer Hospital & Institute
2016-2024
China Medical University
2010-2024
Shanxi Academy of Medical Sciences
2013-2024
Dalian University of Technology
2024
Shanxi Dayi Hospital
2013
Sheng Jing Hospital
2010-2012
Shanxi Provincial Cancer Hospital
2007-2010
Shanxi Medical University
2008-2009
Abstract Background Circular RNAs (circRNAs), a class of noncoding (ncRNAs), may modulate gene expression by binding to miRNAs. Additionally, recent studies show that circRNAs participate in some pathological processes. However, there is large gap the knowledge about circDOCK1 and its biological functions osteogenic sarcoma (OS). Methods Differentially expressed OS cell lines tissues were identified circRNA microarray analysis quantitative real-time PCR (qRT–PCR). To explore actions vivo...
Circular RNAs (circRNAs) are recently emerged to be promising therapeutic targets of tumors. Osteosarcoma is the most prevalent primary bone tumor and third cancer in children adolescents. This study firstly analyzed circRNA microarray osteosarcoma selected circ-0001785 as object. We aimed comprehensively investigate expression pattern biological function progression osteosarcoma. Relative levels miR-1200 normal human osteoblast cell line lines were determined. Bioinformatics analyses...
Osteosarcoma is an aggressive malignant neoplasm and cancerous bone tumor. Quercetin a well-known flavonoid abundant in vegetables, fruits, grains, leaves, red onions. In the present study, we evaluated effects of quercetin-induced inhibition parathyroid hormone receptor 1 (PTHR1) on proliferation, migration, invasion U2OS Saos-2 cells. Following incubation with quercetin (20, 40, 60, 80, or 100 μM) for 48 h, cell viability cells were significantly reduced dose-dependent manner....
Abstract Background Melanoma is the most aggressive skin cancer that derived from pigment cells, accounting for majority of skin-cancer-related deaths. Despite great development and evolution have been made in surgery, radiotherapy adjuvant chemotherapy, prognosis melanoma patients exhibited no significant improvement. Long noncoding RNAs (lncRNAs) are frequently dysregulated involved cancers. LncRNA AFAP1-AS1 has explored various cancers, whereas its role regulatory mechanism not well...
Abstract Under the microenvironment, tumour progression is substantially affected by cell‐cell communication. In spite of mediating effect extracellular nanovesicles (EVs) on communication packaging into circRNAs, EVs circRNA hsa_circ_0000190 (circ‐0000190) in osteosarcoma still not clear. Circ‐0000190 expressions tissues and from plasma were compared between patients controls. Thereafter, receiver operating characteristic (ROC) curve was drawn area under calculated to examine whether...
The long noncoding RNA NR2F1-AS1 has been found to promote the development of hepatocellular carcinoma and endometrial cancer. In this study, we measured expression in osteosarcoma (OS), determined involvement malignant properties OS, investigated underlying mechanisms. was be upregulated OS tumors cell lines. increased level closely associated with advanced clinical stage distant metastasis patients OS. Patients an high-expression group demonstrated significantly shorter overall survival...
BACKGROUND:Zoledronate has anti-bone resorption activity and is reported to reduce skeletal-related events. The objective of this study was test the hypothesis that addition zoledronate in chemotherapy safe effective osteosarcoma. MATERIAL AND METHODS:A total 798 patients, age 25 years above, with newly diagnosed high-grade surgically salvageable malignant osteosarcoma, were included trial. All patients had received standard chemotherapies (n=399). In addition, a regimen, enrolled group also...
The expression levels and detailed functions of TTN-AS1 in osteosarcoma (OS) have not yet been explored.This study aimed to measure OS tissues cell lines, investigate its specific roles the aggressive characteristics cells vitro vivo, elucidate regulatory mechanisms action.TTN-AS1 was high tissue samples lines; overexpression correlated with clinical stage, distant metastasis, shorter overall survival patients.A knockdown inhibited proliferation, migration, invasion induced apoptosis slowed...
The provirus integrating site Moloney murine leukemia virus (PIM) family of serine/threonine protein kinases is composed three members, PIM1, PIM2 and PIM3, which have been identified as oncoproteins in various malignancies. However, their role osteosarcoma (OS) remains largely unknown. This study aimed to examine the expression patterns clinical significance PIM human OS biological effects cell lines. Immunohistochemical staining was used detect archived pathologic material from 43 patients...
JARID1B has been proven to be upregulated in many human malignancies and is correlated with tumor progression. However, its expression clinical significance osteosarcoma are still unclear. Thus, the aim of this study was explore effects tumorigenesis development. In study, we found that levels tissues were significantly higher than those corresponding noncancerous bone tissues. addition, upregulation occurred more frequently specimens from patients a poor prognosis. After transfection cells,...
Background: Osteosarcoma (OS) is the most common primary malignant bone tumor. Hence, there an urgent need to identify effective and safe therapeutic agents against OS. It has been reported that Ilex hainanensis Merr (IME) possesses antitumor properties. Integrin subunit alpha V (ITGAV) important for diagnosis, treatment, prognosis of tumors. Purpose: The objective this study was whether IME can play a role in treatment osteosarcoma by regulating ITGAV. Methods: Western blot real-time PCR...
Our previous study has indicated that the parathyroid hormone type 1 receptor (PTHR1) may play important roles in development and progression of osteosarcoma (OS) by regulating Wnt, angiogenesis, inflammation pathway genes. The goal this was to further illuminate PTHR1 OS investigating upstream regulation mechanisms (including microRNA [miRNA] transcription factors [TFs]) crucial microarray dataset GSE46861 downloaded from Gene Expression Omnibus database, which six tumors with short hairpin...
Osteosarcoma is a highly malignant tumour that occurs in adolescents. Upregulation or the constitutive activation of epidermal growth factor receptor (EGFR) hallmark osteosarcoma. To investigate effect ursolic acid on biological function osteosarcoma, MTT assay was used to detect proliferation HOS and MG63 cells, while flow cytometry analyse cell cycle apoptosis. Transwell Matrigel assays were migration invasion, respectively. Western blot analysis reverse transcription‑quantitative...
3100 Background: Colony-stimulating factor 1 (CSF-1) pathway is involved in the development of various types cancer. Pimicotinib an orally available, selective, potent small molecule CSF-1R inhibitor with significant pre-clinical anti-tumor activity. Here we present results phase trial. Methods: The escalation part employed a 3+3 design starting dose 25 mg QD (28-day/ cycle) to determine maximum tolerated (MTD) and recommended for expansion (RDE). Additional pts selected tumor including...
The US Food and Drug Association has approved interferon-α (IFN-α) interleukin-2 (IL-2) as adjuvant therapy in malignant melanoma. objective of the study was to compare efficacy safety subcutaneous with continuous intravenous IL-2 Chinese patients A total 250 unresectable melanoma were subjected randomized 1 : ratio. Patients received 9×10 IU/m IFN-α (IFN-α group, n=125) or (IL-2 at every 21 days for 4 months. response, progression-free survival, overall adverse effects, cost evaluated by...
Abstract In this study,we investigated a the combination of osimertinib/ gefitinib/ erlotinib with cytotoxic chemotherapy for EGFR-mutated positive lung adenocarcinoma patients in long-term survival outcomes. Method We enrolled Ⅲb-IV stage patients，Patients receiving standard Osimertinib,Gefitinib,Erlotinip alone treatment and Osimertinib,Gefitinib Erlotinip were retrospectively reviewed. Result First generation Chemical-TKItherapy PFS vs TKI therapy PFS.P<0.05.Mean Survival...
Abstract This study aimed to determine the interactions between parathyroid hormone type 1 receptor (PTHR1) and angiotensinogen (AGT) effects of these agents on osteosarcoma (OS). We constructed a stably transfected mouse OS K7M2 cell line (shPTHR1‐ K7M2) using shRNA knocked down AGT in cells siRNA‐AGT. The transfection efficiency expression AGT, chemokine C‐C motif 3 (CCR3), (C‐C motif) ligand 9 (CCL9) were determined real‐time quantitative PCR. Cell viability colony formation assessed...