A5100775408- Bone Metabolism and Diseases
- MicroRNA in disease regulation
- Bone health and osteoporosis research
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Signaling Pathways in Disease
- Ferroptosis and cancer prognosis
- Bone health and treatments
- NF-κB Signaling Pathways
- Mycobacterium research and diagnosis
- Obesity, Physical Activity, Diet
- Public-Private Partnership Projects
- Eosinophilic Esophagitis
- RNA and protein synthesis mechanisms
- Redox biology and oxidative stress
- Nutrition, Genetics, and Disease
- Fibroblast Growth Factor Research
- Construction Project Management and Performance
- Bone Tumor Diagnosis and Treatments
- Genetic Associations and Epidemiology
- Mesenchymal stem cell research
- Microbial Metabolic Engineering and Bioproduction
- Kruppel-like factors research
- Silk-based biomaterials and applications
China Medical University
2012-2025
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2024
Jiangnan University
2024
Sheng Jing Hospital
2009-2012
Shanghai Jiao Tong University
2011
The osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) is key for formation, and its imbalance leads to osteoporosis. Forkhead Box Protein G1 (FOXG1) associated with osteogenesis, however, the effect FOXG1 on osteogenesis BMSCs ovariectomy (OVX)-induced loss unknown. In our study, expression in increases after induction. overexpression significantly osteoblast marker ALP activity, calcium deposition, while opposite results are observed knockdown BMSCs,...
Previous studies have suggested that microRNAs (miRNAs/miRs) may positively or negatively control osteogenic differentiation and mineralization by targeting negative regulators of osteogenesis important factors. miR‑21 is in osteoblast Smad7 a critical regulator differentiation, which inhibits proliferation, mouse cells. However, the association between remain to be elucidated. In present study, was found promote level increase matrix MC3T3‑E1 Furthermore, identified as direct target The...
MicroRNAs (miRNAs/miRs) are post‑transcriptional regulators that serve important roles in osteoclastogenesis and bone metabolism; however, the of miRNAs have not been completely clarified. The present study aimed to investigate effects miR‑100‑5p on mechanism liver‑bone endocrine metabolism. A miRNA microarray analysis was conducted evaluate expression profile during receptor activator nuclear factor‑κB ligand‑stimulated osteoclastogenesis. Hematoxylin eosin tartrate‑resistant acid...
Despite improvements in surgical resection and adjuvant chemotherapy, the prognosis outcomes of patients with osteosarcoma remains poor due to occurrence metastasis or relapse. Monocyte chemoattractant protein-1-induced protein-1 (MCPIP1), a zinc-finger RNA-binding protein, is known regulate inflammatory responses repress breast cancer growth. However, regulation MCPIP1 by microRNAs has not been clearly elucidated osteosarcoma. In this study, we found that miR-421 expression was upregulated...
Abstract Bone marrow-derived mesenchymal stem cells (BMSCs) in postmenopausal osteoporosis models exhibit loss of viability and multipotency. Identification the differentially expressed RNAs osteoporotic BMSCs could reveal mechanisms underlying BMSC dysfunction under physiological conditions, which might improve cell therapy tissue regeneration. In this study, we performed high-throughput RNA sequencing showed that novel long non-coding (lncRNA) LNC_000052 its co-expressed mRNA PIK3R1 were...
Abstract Background Osteoporosis is a worldwide severe bone disease. This study aimed to evaluate the effect of polyphyllin VII on genesis osteoclasts from marrow macrophages (BMMs) and its potentiality as therapeutic drug for osteoporosis. Methods BMMs were induced differentiate into by RANKL M-CSF. The cells then treated with various concentrations VII. Intracellular reactive oxygen species (ROS) measurement assay, resorption pit formation tartrate-resistant acid phosphatase (TRAP)...
Chronic long-term glucocorticoid use causes osteoporosis partly by interrupting osteoblast homeostasis and exacerbating bone loss. Arbutin, a natural hydroquinone glycoside, has been reported to have biological activities related the differentiation of osteoblasts osteoclasts. However, role underlying mechanism arbutin in glucocorticoid-induced are elusive. In this study, we demonstrated that administration ameliorated osteoporotic disorders dexamethasone (Dex)-induced mouse model, including...
Arbutin is a natural compound extracted from various plants, including bearberry leaves, that exerts multiple effects skin whitening, anti‑inflammatory and oxidative stress‑protective properties. However, the of arbutin on osteoblasts remain unknown. The aim present study was to investigate function mechanisms proliferation differentiation MC3T3‑E1 mouse osteoblast precursor cells in vitro. treated with assessed using Cell Counting Kit‑8 assay 5‑ethynyl‑2'‑deoxyuridine labeling assay....
Bone remodeling is a vital physiological process of healthy bone tissue in humans. It characterized by the formation osteoblasts and its resorption osteoclasts, resorbed osteoclasts replaced through differentiation activity osteoblasts. Imbalances this lead to pathological conditions, including osteoporosis. Intermedin (IMD) as newly discovered peptide calcitonin (CT) family peptides, which shares similar functions with CT, gene‑related amylin resorption. However, mechanism underlying effect...
Background & Aims: MicroRNAs (miRNAs) have been shown to play import roles in many cancers, including breast cancer. The majority of previous studies employed network analysis identify key miRNAs cancer progression. However, most dysregulated miRNA networks were constructed based on the expression dysregulation and target genes. Methods: relations between genes computed by Spearman correlation separately normal samples. We calculated scores miRNA-mRNA regulatory relations. A (DMTN) was from...
Osteoporosis is characterized by the progressive loss of bone mass and micro‑architectural deterioration tissue, leading to fragility an increased risk fracture. Gallium has demonstrated efficacy in treatment several diverse disorders that are accelerated loss. Osteoblasts orchestrate degradation expressing receptor activator NF‑κB ligand (RANKL), however they additionally protect skeleton secreting osteoprotegerin (OPG). Therefore, relative concentration RANKL OPG a key determinant...
Background: Osteosarcoma (OSA) is the most prevalent form of malignant bone cancer and it occurs predominantly in children adolescents. OSA associated with a poor prognosis highest cause cancer-related death. However, there are few biomarkers that can serve as reasonable assessments prognosis. Methods: Gene expression profiling data were downloaded from dataset GSE39058 GSE21257 Expression Omnibus database well TARGET database. Bioinformatic analysis integration was conducted to discover...
<title>Abstract</title> Background & Aims Acute-on-chronic liver failure (ACLF) has a high incidence and mortality rate, which become an urgent clinical problem to be solved.Traditional Chinese medicine (TCM) been widely applied in the experimental researches of ACLF. But its specific mechanism is not yet fully understood. This study attempted identify effective active ingredients, key targets, biological mechanisms herbal medicines Chi Shao (<italic>Paeoniae radix</italic> Rubra) Fu Zi...
An improved understanding of the molecular actions underpinning bone marrow mesenchymal stem cell (BMSC) differentiation could highlight new therapeutics for osteoporosis (OP). Current evidence indicates that microRNAs (miRNAs) exert critical roles in many biological systems, including osteoblast differentiation. In this study, we examined miR-468-3p effects on osteogenic (OD). Distinct reductions were identified during OD. MiR-468-3p also suppressed BMSC OD gain- and loss-of-function...
BOT project financing, as a way to introduce social capital address the funding gap in government infrastructure construction, has gained more attention