Abstract Background Circular RNAs (circRNAs), a class of noncoding (ncRNAs), may modulate gene expression by binding to miRNAs. Additionally, recent studies show that circRNAs participate in some pathological processes. However, there is large gap the knowledge about circDOCK1 and its biological functions osteogenic sarcoma (OS). Methods Differentially expressed OS cell lines tissues were identified circRNA microarray analysis quantitative real-time PCR (qRT–PCR). To explore actions vivo...

Abstract Background Melanoma is the most aggressive skin cancer that derived from pigment cells, accounting for majority of skin-cancer-related deaths. Despite great development and evolution have been made in surgery, radiotherapy adjuvant chemotherapy, prognosis melanoma patients exhibited no significant improvement. Long noncoding RNAs (lncRNAs) are frequently dysregulated involved cancers. LncRNA AFAP1-AS1 has explored various cancers, whereas its role regulatory mechanism not well...

Current study was aimed to investigate the effect of dihydromyricetin on hydrogen peroxide induced oxidative stress in osteosarcoma cells. MTT assay showed that treatment at a concentration 100 μM caused significant (p < 0.005) reduction viability MG63 However, cell by completely prevented incubation with 30 dose dihydromyricetin. Treatment for 24 h led condensation chromatin material, rounding shape and detachment The results from flow cytometry using annexin V-FITC PI double staining...

BACKGROUND:Zoledronate has anti-bone resorption activity and is reported to reduce skeletal-related events. The objective of this study was test the hypothesis that addition zoledronate in chemotherapy safe effective osteosarcoma. MATERIAL AND METHODS:A total 798 patients, age 25 years above, with newly diagnosed high-grade surgically salvageable malignant osteosarcoma, were included trial. All patients had received standard chemotherapies (n=399). In addition, a regimen, enrolled group also...

The present study aims to analyse the clinical presentation, treatment and prognosis of a group patients with orbital cavernous venous malformation (OCVM) an insidious onset.The data 35 OCVM treated at our centre between 2003 2020 were retrospectively analysed. OCVMs classified as one six types (I-VI) according position tumour. characteristics, methods follow-up results recorded.A total under optic nerve sheath in apex area or common tendon ring (Types I II) included study. In 20 cases...

Background: Osteosarcoma (OS) is the most common primary malignant bone tumor. Hence, there an urgent need to identify effective and safe therapeutic agents against OS. It has been reported that Ilex hainanensis Merr (IME) possesses antitumor properties. Integrin subunit alpha V (ITGAV) important for diagnosis, treatment, prognosis of tumors. Purpose: The objective this study was whether IME can play a role in treatment osteosarcoma by regulating ITGAV. Methods: Western blot real-time PCR...

Our previous study has indicated that the parathyroid hormone type 1 receptor (PTHR1) may play important roles in development and progression of osteosarcoma (OS) by regulating Wnt, angiogenesis, inflammation pathway genes. The goal this was to further illuminate PTHR1 OS investigating upstream regulation mechanisms (including microRNA [miRNA] transcription factors [TFs]) crucial microarray dataset GSE46861 downloaded from Gene Expression Omnibus database, which six tumors with short hairpin...

Osteosarcoma is a highly malignant tumour that occurs in adolescents. Upregulation or the constitutive activation of epidermal growth factor receptor (EGFR) hallmark osteosarcoma. To investigate effect ursolic acid on biological function osteosarcoma, MTT assay was used to detect proliferation HOS and MG63 cells, while flow cytometry analyse cell cycle apoptosis. Transwell Matrigel assays were migration invasion, respectively. Western blot analysis reverse transcription‑quantitative...

Abstract Background This study analyzed the clinical features, imaging manifestations, histopathology, immunohistochemistry, and surgical approaches of orbital solitary fibrous tumor (OSFT), as well factors for postoperative recurrence such disease. Methods The data 16 patients with OSFT treated in our center from 2003 to 2020 were retrospectively, symptoms, treatment methods, follow-up results recorded. Results Of patients, 8 females (50.0 %) males %); average age was 37 ± 7 years median...

The US Food and Drug Association has approved interferon-α (IFN-α) interleukin-2 (IL-2) as adjuvant therapy in malignant melanoma. objective of the study was to compare efficacy safety subcutaneous with continuous intravenous IL-2 Chinese patients A total 250 unresectable melanoma were subjected randomized 1 : ratio. Patients received 9×10 IU/m IFN-α (IFN-α group, n=125) or (IL-2 at every 21 days for 4 months. response, progression-free survival, overall adverse effects, cost evaluated by...

Tuberculum sellae meningiomas (TSMs) present a special symptom because of the adherence and compression to optic nerve, artery, chiasm. A significant number patients with TSMs appear visual deficits. This study aimed investigate surgical indications exploring canal prognostic factors in neurosurgical treatment TSMs.Totally 21 TSM, who were operated from September 2007 August 2011 Department Neurosurgery, Tongren Hospital enrolled this study. Results orbital computed tomography (CT) magnetic...

Objective This study aimed to assess the effectiveness of 3 endoscopic endonasal approaches for management cerebrospinal fluid (CSF) leaks and meningoencephaloceles in lateral recess sphenoid sinus (LRSS). Study Design Retrospective study. Setting University hospital. Methods retrospectively reviewed 49 patients with CSF LRSS. Three surgical repair were indicated based on 5 different Rhoton’s types The postoperative symptoms, complications, follow‐up outcomes investigated evaluated. Results...

Objective: Phantom limb pain (PLP) was a common problem in malignant tumor amputees that can cause considerable suffering. The purposes of this study were to determine the incidence and factors associated with occurrence post-operation PLP, stump (SLP), phantom sensations (PLS) within first month after surgery. Additionally, differences phenomena between upper lower extremities investigated. Methods: In total, 162 participated retrospective who underwent amputation 2012 2019. Clinical...

This study analyzes two kinds of surgical methods for the treatment optic pathway gliomas (OPGs) in intraorbital segment, as well outcomes OPGs.The clinical data 86 patients with OPGs treated our center was analyzed retrospectively, and symptoms, methods, follow-up results were recorded.For nerve sheath incision performed to remove a tumor while retaining Group 1 (n=36). The simultaneously removed without group 2 (n=50). effects design on post-surgical outcome are: One patient (1/36, 2.8%)...

Objective: To analyze the efficacy of endoscopic surgery for frontal sinus meningoencephalocele and cerebrospinal fluid (CSF) leaks, to explore surgical strategy. Methods: A total 35 patients with CSF leaks who underwent transnasal at Beijing Tongren Hospital, Capital Medical University between May 2007 December 2023 were enrolled in this retrospective case series, including 29 males 6 females, age (35.23±15.76) years. High-resolution CT magnetic resonance cisternography undertaken before...