A5100686878- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
- Natural product bioactivities and synthesis
- Musculoskeletal synovial abnormalities and treatments
- Nitric Oxide and Endothelin Effects
- Trace Elements in Health
- Sulfur Compounds in Biology
- Animal Genetics and Reproduction
- Knee injuries and reconstruction techniques
- Vanadium and Halogenation Chemistry
- Bone Tumor Diagnosis and Treatments
- Vitamin K Research Studies
- Plant Genetic and Mutation Studies
- Ion Channels and Receptors
- Total Knee Arthroplasty Outcomes
- Healthcare and Venom Research
- Phytochemicals and Antioxidant Activities
- Pluripotent Stem Cells Research
- Lipid metabolism and biosynthesis
- Bone fractures and treatments
- Exercise and Physiological Responses
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Drug-Induced Hepatotoxicity and Protection
China Medical University
2008-2023
Sheng Jing Hospital
2012
Okayama University
1990-1992
University of Kerala
1976
Osteoarthritis (OA) is a disease characterized by non-bacterial inflammation. Histone deacetylase 3 (HDAC3) crucial positive regulator in the inflammation that leads to development of non-OA inflammatory disease. However, precise involvement HDAC3 OA still unknown, and underlying mechanism exercise therapy requires more research. We investigated therapy-treated OA. Expression levels HDAC3, disintegrin metalloproteinase with thrombospondin motifs-5 (ADAMTS-5), matrix metalloproteinase-13...
The aim was to investigate the effects of different frequencies treadmill exercise with total time being constancy on articular cartilage, lipoxin A4 (LXA4) and NF-κB pathway in rat model monosodium iodoacetate-induced osteoarthritis (OA). Fifty male Sprague-Dawley rats were randomly divided into five groups (n = 10): controls (CG), knee OA (OAG), + once daily (OAE1), twice daily, rest interval between exercise>4h (OAE2) three times (OAE3). Rats evaluated after completing program (speed, 18...
The aim of the present study was to investigate potential alterations in articular cartilage a rat model monosodium iodoacetate (MIA)‑induced osteoarthritis (OA) with or without treatment moderate treadmill exercise. A total 30 male Sprague‑Dawley rats were randomly divided into three groups (n=10), including control, OA and exercise (OAE) groups. Rats evaluated upon completing program (speed, 18 m/min; min/day; 5 days/week for 4 weeks). Interleukin (IL)‑1β IL‑4 levels serum intra‑articular...
This study assessed the effects of limb position on venous hemodynamics and blood loss after primary total knee arthroplasty (TKA). First, flow velocity was detected by color Doppler imaging in seven young volunteers leg elevated 25 cm with full extension or mild flexion. Next, 108 consecutive TKA patients were randomized into flexion groups. Both groups had at ankle over a specific backing pad for 72 hours postoperatively. In group, flexed mildly (< 30 degrees) during this period. extended...
Abstract Normal human fibroblasts obtained from a whole embryo were malignantly transformed with only 60 Co gamma rays, but after extensive passage. The exposed intermittently to 13 times, 2,800 rads in total, the primary culture 40th passage level. At 50th level cells became morphologically changed, showing chromosomal abnormalities, and serial passages showed them be immortalized. They not tumorigenic on transplantation into nude mice, malignant passage; i.e., at 547th days initiation of...
The expression of transient receptor potential cation channel V5 (TRPV5) in articular cartilage cells under normal and exercise loading conditions was measured, the clinical significance, order to define its role formation tissues analyzed. In osteoarthritis (OA) Sprague Dawley rats severity injury observed, TRPV5 measured by immunohistochemistry following loading, association with pathological characteristics (including lesions) results immunohistochemical assay showed that percentage...
The treatment for intertrochanteric femoral fractures (IFF) among the elderly has been a controversial topic. Hemiarthroplasty (HA) and proximal nail antirotation (PFNA) have their own advantages in management of IFF. Hence, this study aims to compare analyze differences effectiveness both procedures on IFF elderly.Overall, 99 patients (81.09 ± 8.29 years; 68 women) underwent HA or PFNA from January 2016 May 2020. were classified according Arbeitsgemeins für Osteosynthesefragen (AO)...
Abstract Osteoarthritis (OA) is characterized by synovitis, cartilage degeneration and exercise therapy has been recognized as first line therapy. The related exosome involved in the interaction between fibroblast-like synoviocytes (FLSs) chondrocytes could be a novel promising strategy for treating OA. In this study, PPARγ was upregulated FLSs under single cell transcriptome sequencing. Then, we investigated underlying mechanisms of PPARγ-treated derived on OA vivo vitro. Our data revealed...
The present experiment was undertaken to study what types of human cancers are responsive the antiproliferative effects suramin. malignant cells used were as follows: cervical cancer (HeLa), mammary (MCF-7), bladder (EJ), hepatoma (HuH-7, PLC/PRF/5), embryonal carcinoma (PA-1), in vitro transformed fibroblasts (KMST-6, SUSM-1, VA-13), five myeloma cell lines (KMM-1, KMS-5, KMS-11, KMS-12, RPMI 8226), Burkitt's lymphoma (Raji), acute promyelocytic leukemia (HL-60), chronic myelocytic (K562),...