A5078563583- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Cancer-related gene regulation
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- Retinal Development and Disorders
- Angiogenesis and VEGF in Cancer
- Immunotherapy and Immune Responses
- Gastrointestinal motility and disorders
- Advanced Glycation End Products research
- Chronic Myeloid Leukemia Treatments
- CRISPR and Genetic Engineering
- Invertebrate Immune Response Mechanisms
- Congenital gastrointestinal and neural anomalies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Ferroptosis and cancer prognosis
- Plant Virus Research Studies
- Cardiovascular and Diving-Related Complications
- Ophthalmology and Visual Impairment Studies
- High Altitude and Hypoxia
- Computational Drug Discovery Methods
Zhongda Hospital Southeast University
2017-2025
Wuhan Sports University
2024
Zhengzhou University
2021-2022
Qilu Hospital of Shandong University
2010-2022
Zhengzhou Children's Hospital
2021-2022
Southeast University
2011-2021
Zhejiang Cancer Hospital
2021
University of Chinese Academy of Sciences
2021
Shandong University
2015
Jilin Medical University
2015
HoxA9, a homeodomain-containing transcription factor, is mis-expressed in over half of acute myeloid leukemia (AML) cases, and associated with poor prognosis. Previous studies indicated that HoxA9 binds to the eukaryotic translation initiation factor eIF4E primary specimens stimulated RNA export efficiency selected RNAs via eIF4E. However, relevance this its leukemogenic transformation capacity was unknown. Here, we used double point mutation (HoxA9AA) disrupt physical functional interaction...
Ferroptosis involves in the development and therapeutic response of various types tumors. This study aims to explore ferroptosis-related prognostic genes that could further accurately stratify AML patients.We investigated prognosis significance by Univariate multivariate Cox proportional hazards regression analyses. With methylation data TCGA samples, we looked for sites associated with compared correlation between mRNA expression. R software 'edgeR' packages were used identify DEGs...
In Brief Purpose: To investigate the effect of single nucleotide polymorphisms (SNPs) and haplotypes in genes encoding age-related maculopathy susceptibility 2 (LOC387715/ARMS2) high-temperature requirement A-1 (HTRA1) a case-control study Chinese cohort individuals with exudative macular degeneration (AMD). Methods: We genotyped SNPs, namely, LOC387715 rs10490924 HTRA1 rs11200638, 159 AMD patients 140 age- sex-matched control subjects. All four possible these two SNPs were detected....
<i>Aims:</i> To evaluate the association between vascular endothelial growth factor <i>(VEGF)</i> gene polymorphism and risk of neovascular age-related macular degeneration (AMD) in a case-control study Chinese cohort. <i>Methods:</i> We genotyped 4 common single-nucleotide polymorphisms (SNPs), namely –460T/C (rs833061), +405C/G (rs2010963), +674C/T (rs1413711) +936C/T (rs3025039), simultaneously detected 7 tag SNPs (tSNPs) <i>VEGF</i> gene,...
Purpose: To identify the differential profiles of lipids in aqueous humor (AH) between control and diabetic cataract patients. Methods: The lipidomic 19 samples from patients with (diabetic group) 32 controls (control were analyzed using liquid chromatography tandem mass spectrometry (LC-MS/MS). Differentially expressed two groups determined through partial least-squares-discriminant analysis principal component analysis. Receiver operating characteristic curve was calculated to evaluate...
Abstract Objective To determine the effect of deletion interleukin‐1 receptor antagonist (IL‐1Ra) protein in an animal model rheumatoid arthritis. Methods BALB/c mice deficient IL‐1Ra (IL‐1Ra −/− ) were bred with collagen‐induced arthritis (CIA)–susceptible DBA/1 and B10 transgenic for HLA–DRB1*0101 (B10.DR1). After generation on B10.DR1 backgrounds, observed development spontaneous immunized induction CIA. Results We found that although (BALB/c spontaneously developed chronic inflammatory...
The aim of this study was to analyze the changes middle hepatic vein (MHV) spectra in patients with pulmonary hypertension (PH) caused by congenital heart disease (CHD) and determine proper parameters MHV predict PH. Eighty CHD were included, whose artery pressure measured via right catheterization, detected echocardiography. peak value velocity (V) time integral (VTI) waves, including S wave, D wave A at end inspiration. values that predictive PH evaluated their cut-off points determined....
Abstract Background This study was performed to investigate the correlation of erythropoietin gene polymorphisms with diabetic retinopathy ( DR ) in a C hinese cohort type 2 diabetes mellitus T2DM ). Design Case–control held Q ilu hospital S handong U niversity, hina. Participants 792 individuals were involved, classified as groups n = 448) and non‐ NDR ; 344). The group subdivided into proliferative PDR 220) NPDR 228). Methods Three single‐nucleotide polymorphisms, rs1617640, rs507392...
B6 mice are of intermediate susceptibility to collagen-induced arthritis (CIA) while Balb/c resistant, but highly susceptible proteoglycan-induced arthritis. Antigen presentation is H-2 directed the disease that results thought be driven by regions outside MHC therefore, CXB mouse strains afford opportunity look at influence these on CIA. H2-b predicted show variation in parameters relative C57Bl/6, depending which chromosome present. Nine thirteen H-2b one has a recombined region (CXB9)....
<i>Aims:</i> Octreotide exhibits anti-angiogenic activity in animal models of retinopathy prematurity and clinical cases proliferative diabetic retinopathy. In this study, we tested the applicability using octreotide for inhibiting experimental choroidal neovascularization (CNV) rats. <i>Methods:</i> Of 15 adult rats used, 3 served as non-laser-treated controls. CNV was induced right eye remaining 12 by laser photocoagulation. These were divided into two groups (n = 6...
To investigate polymorphisms in the pigment epithelium-derived factor (PEDF) gene a Chinese cohort with exudative age-related macular degeneration (AMD).Two common single nucleotide (SNPs), Met72Thr (rs1136287) and -5736T>C (rs12150053), were genotyped, four tagSNPs (tSNPs) detected statistically PEDF of 168 AMD patients 230 age- sex-matched control participants. Genetic analyses for additive, dominant, recessive models performed on all available genotype data. All possible haplotypes these...
The association between lipoprotein-associated phospholipase A2 (Lp-PLA2) G994T gene polymorphism and the risk of ischemic stroke is unclear. aim this study to investigate influence Lp-PLA2 genetic variant on pathogenesis in Chinese population. A total 348 patients with a clinical diagnosis 260 gender-matched control subjects under physical examination were recruited from hospitals genotyped for polymorphism. results showed that there was significant difference genotype distribution two...
DQB1*0604 alleles did not show significant differences between IBS-D patients and healthy controls.Furthermore, with DQB1*03positive DQB1*0603-negative showed more severe colonic permeability lower serum IL-10 level ZO1 compared to controls or even other genotypes.The present study indicated the DQB1*02 DQB1*0603 are related occurrence in Guangdong, China, mechanism of disease may be reduced levels.
Objective: To study the clinical characteristics and risk factors of post polypectomy electrocoagulation syndrome (PPECS) in children. Methods: Clinical data 23 children with PPECS Children's Hospital Affiliated to Zhengzhou University from January 2015 December 2019 were retrospectively analyzed. Additionally, 115 without who had performed by same endoscopist at time collected into control group. The morbidity, therapeutic protocol analyzed, analyzed Logistic regression. Results: Among...
To investigate the role of irisin in exercise-induced improvement renal function type 2 diabetic rats.
<b><i>Purpose:</i></b> To establish and evaluate a novel in vitro model of retinal ischemia, to determine whether an autocrine pathway microvascular endothelial cells (RMVECs) by vascular growth factor (VEGF) signaling plays role based on this model. <b><i>Methods:</i></b> Primary RMVECs were isolated from the retinas C57/BL6J rats identified evaluation for FITC-marked CD31. The hypoxia models established with biobag at time 12, 24, 48 72 h,...