A5018886262- Growth Hormone and Insulin-like Growth Factors
- Hormonal and reproductive studies
- Genetics, Aging, and Longevity in Model Organisms
- Sperm and Testicular Function
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Stress Responses and Cortisol
- Hypothalamic control of reproductive hormones
- Animal Genetics and Reproduction
- Circadian rhythm and melatonin
- Reproductive Biology and Fertility
- Regulation of Appetite and Obesity
- Sexual Differentiation and Disorders
- Digestive system and related health
- Ovarian function and disorders
- Dietary Effects on Health
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Neuroendocrine regulation and behavior
- Hormonal Regulation and Hypertension
- Estrogen and related hormone effects
- CRISPR and Genetic Engineering
- Cannabis and Cannabinoid Research
- Cancer, Hypoxia, and Metabolism
Southern Illinois University School of Medicine
2016-2025
Southern Illinois University Carbondale
2000-2023
Neurosciences Institute
2022
University of Alabama at Birmingham
2016
University of Buenos Aires
1995-2014
British Geriatrics Society
2011-2013
University of Illinois at Springfield
2009-2013
Geriatric Research Education and Clinical Center
2013
University of Michigan
1984-2013
Indiana University School of Medicine
2013
Testosterone (T) levels in the plasma of male laboratory rats and mice were measured by radioimmunoassay. There was a striking individual variation with values ranging from less than 1 ng/ml to over 30 same age strain housed under identical conditions. Using chronic indwelling catheters inserted into jugular vein, blood collected adult conscious every 24 hr for 4 or 8 days min 2l/2 hr. Considerable differences T observed between different animals, 2– 5–fold fluctuations concentrations...
Dietary protein restriction is increasingly recognized as a unique approach to improve metabolic health, and there increasing interest in the mechanisms underlying this beneficial effect. Recent work indicates that hormone FGF21 mediates effects of young mice. Here we demonstrate increases lifespan, reduces frailty, lowers body weight adiposity, improves physical performance, glucose tolerance, alters various markers within serum, liver, adipose tissue wildtype male Conversely, mice lacking...
Reduced intake of nutrients [calorie restriction (CR)] extends longevity in organisms ranging from yeast to mammals. Mutations affecting somatotropic, insulin, or homologous signaling pathways can increase life span worms, flies, and mice, there is considerable evidence that reduced secretion insulin-like growth factor I insulin are among the mechanisms mediate effects CR on aging In present study, mice with targeted disruption hormone (GH) receptor [GH receptor/GH-binding protein knockout...
Previous studies have shown that dermal fibroblast cell lines derived from young adult mice of the long-lived Snell dwarf mutant stock are resistant, in vitro, to cytotoxic effects H(2)O(2), cadmium, UV light, paraquat, and heat. We show here similar resistance profiles seen cells a related mutant, Ames mouse, growth hormone receptor-null resistant but not cadmium. Resistance H(2)O(2) 1-wk-old or normal mice, thus donors reflects developmental processes, presumably dependent, take place...
Reduced IGF-I/insulin signaling and caloric restriction (CR) are known to extend the life span delay age-related diseases. To address interaction of these two interventions, we subjected normal (N) long-lived GH receptor knockout (GHRKO) mice CR for 20 months starting at weaning. We also used bovine transgenic (bGH Tg) mice, which overexpress short-lived insulin resistant, comparison. Circulating IGF-I levels were reduced by in N animals, whereas GHRKO animals exhibited very low undetectable...
Summary Sir2 is an NAD + ‐dependent deacetylase that regulates lifespan in yeast, worms and flies. The mammalian orthologs of include SIRT1 humans mice. In this study, we analyzed the level human lung fibroblasts (IMR90) mouse embryonic (MEFs) from mice with normal, accelerated, delayed aging. protein, but not mRNA, decreased significantly serial cell passage both murine cells. Mouse rapidly prematurely senescent (p44 Tg) MEFs, remained high MEFs senescence (Igf‐1r–/–), was inversely...
Mutant dwarf and calorie-restricted mice benefit from healthy aging unusually long lifespan. In contrast, mouse models for DNA repair-deficient progeroid syndromes age die prematurely. To identify mechanisms that regulate mammalian longevity, we quantified the parallels between genome-wide liver expression profiles of with those two extremes Contrary to expectation, find significant, associations long-lived mice. Subsequent analysis significantly over-represented biological processes...
Journal Article Prolactin, Growth Hormone, Luteinizing Hormone Receptors, and Seasonal Changes in Testicular Activity the Golden Hamster Get access F. BEX, BEX 1Worcester Foundation for Experimental Biology Shrewsbury, Massachusetts 01545; Department of Biobehavioral Sciences, University Connecticut (B.D.G.) Storrs, 0626 Search other works by this author on: Oxford Academic Google Scholar A. BARTKE, BARTKE B. D. GOLDMAN, GOLDMAN S. DALTERIO Endocrinology, Volume 103, Issue 6, 1 December...
A plethora of hormones regulate many the body's functions, including growth and development, metabolism, electrolyte balances, reproduction. Numerous glands throughout body produce hormones. The hypothalamus produces several releasing inhibiting that act on pituitary gland, stimulating release Of hormones, other located in various regions body, whereas directly affect their target organs. Other hormone-producing include adrenal glands, which primarily cortisol; gonads (i.e., ovaries testes),...
Male house mice paired with a normal female for 1 week do not have higher plasma testosterone levels than males that remain in all-male groups, but markedly elevated 30 to 60 minutes after the resident is replaced by another female. Elevation of these similar isolated female, does depend on copulation strange occurs under housing conditions permit continuous exposure odors other females and males, occur when male minutes. The elevation thus appears be specific endocrine response an encounter...
Aging is a three-stage process: metabolism, damage, and pathology. The biochemical processes that sustain life generate toxins as an intrinsic side effect. These cause of which small proportion cannot be removed by any endogenous repair process thus accumulates. This accumulating damage ultimately drives age-related degeneration. Interventions can designed at all three stages. However, intervention in metabolism only modestly postpone pathology, because production so property metabolic...
The evolutionarily conserved target of rapamycin (TOR) signaling controls growth, metabolism, and aging. In the first robust demonstration pharmacologically-induced life extension in mammals, longevity was extended mice treated with rapamycin, an inhibitor mechanistic TOR (mTOR). However, detrimental metabolic effects treatment were also reported, presenting a paradox improved survival despite impairment. How lifespan such paradoxical unclear. Here we show that only observed during early...
Abstract The postnatal development of the Sertoli cell barrier, tubular lumen, fluid flow, and cytoskeletal elements in myoid cells was investigated Sprague‐Dawley rat. With aid hypertonic fixatives, a barrier to rapid entry noted majority tubules on 15th 16th (p.n.) days completely formed all prior p.n. day 18. actin forming ecto‐plasmic specialization (ES), complex related occluding junctions composing began its during period initial formation (16 day) progressively attained adult...