A5089647803- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Sleep and Wakefulness Research
- Fibroblast Growth Factor Research
- Pancreatic function and diabetes
- Neuroscience of respiration and sleep
- Neuroscience and Neuropharmacology Research
- Circadian rhythm and melatonin
- Diet and metabolism studies
- Epigenetics and DNA Methylation
- Genetic Syndromes and Imprinting
- Neuroinflammation and Neurodegeneration Mechanisms
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Diet, Metabolism, and Disease
- Retinal Development and Disorders
- Diabetes Treatment and Management
- Glaucoma and retinal disorders
- Photoreceptor and optogenetics research
- Optical Imaging and Spectroscopy Techniques
- Visual perception and processing mechanisms
- Olfactory and Sensory Function Studies
- Human-Automation Interaction and Safety
- Ocular and Laser Science Research
- Sleep and Work-Related Fatigue
Pennington Biomedical Research Center
2013-2025
Louisiana State University
2021-2022
University of Alabama at Birmingham
2004-2014
Louisiana State University System
2009-2010
McMaster University
1983
Kansas State University
1968
Dietary protein restriction is increasingly recognized as a unique approach to improve metabolic health, and there increasing interest in the mechanisms underlying this beneficial effect. Recent work indicates that hormone FGF21 mediates effects of young mice. Here we demonstrate increases lifespan, reduces frailty, lowers body weight adiposity, improves physical performance, glucose tolerance, alters various markers within serum, liver, adipose tissue wildtype male Conversely, mice lacking...
Dietary protein restriction increases adipose tissue uncoupling 1 (UCP1), energy expenditure and food intake, these effects require the metabolic hormone fibroblast growth factor 21 (FGF21). Here we test whether induction of during requires UCP1, promotes a resistance to cold stress, is dependent on concomitant hyperphagia. Wildtype, Ucp1-KO Fgf21-KO mice were placed control low (LP) diets assess changes in expenditure, intake other endpoints. Deletion Ucp1 blocked LP-induced exacerbated...
The nucleus of the solitary tract (NST), located in dorsomedial medulla, is site visceral sensory modulation a variety homeostatic reflexes. Given recent advancements understanding active regulation synaptic information flow by astrocytes, we sought to determine whether afferent inputs NST neurons also activates astrocytes. Using confocal, live-cell calcium imaging brainstem slices, investigated possibility that stimulation vagal afferents, major input into NST, activated as indicated...
Glucose homeostasis is maintained through interplay between central and peripheral control mechanisms which are aimed at storing excess glucose following meals mobilizing these same stores during periods of fasting. The nucleus the solitary tract (NST) in dorsal medulla has long been associated with detection availability homeostasis. Recent evidence emerged supports involvement astrocytes aim present study was to investigate whether NST-astrocytes respond physiologically relevant decreases...
Metabolic inflexibility to Western high-fat diets may contribute the obesity epidemic. However, validated methods for assessing metabolic flexibility (MetFlex) meals are currently lacking. The purpose of this study was evaluate reliability a novel approach determining MetFlex meal and compare it with gold standard measuring high-carbohydrate loads. Eight healthy adults were enrolled in our study, which consisted following two assessments MetFlex: 1) fat, via overnight stays chamber separated...
Leptin is a hormone released from adipose tissue. While this normally acts to reduce feeding behavior and increase energy expenditure, in obesity, resistance these effects occurs even though the large amounts. Although leptin no longer works suppress obese, retains its potent on other autonomic functions such as blood pressure regulation. has been associated with hypertension increased sympathetic activity. Therefore, emerging major contributor hypertensive state observed obesity....
Abstract Dietary protein restriction induces adaptive changes in food preference, increasing consumption over carbohydrates or fat. We investigated whether motivation and reward signaling underpin these preferences. In an operant task, protein-restricted male mice responded more for liquid rewards, but not carbohydrate, fat, sweet rewards compared to non-restricted mice. The restriction-induced increase responding was absent Fgf21 -KO with neuron-specific deletion of the FGF21 co-receptor...
Dietary protein restriction induces adaptive changes in food preference, increasing consumption over carbohydrates or fat. We investigated whether motivation and reward signaling underpin these preferences. In an operant task, protein-restricted male mice responded more for liquid rewards, but not carbohydrate, fat, sweet rewards compared to non-restricted mice. When the number of responses required access varied, exhibited higher at moderate high response requirements. The...
The effect of silence, slow music, and Tijuana Brass music on the control activity twenty four automotive drivers was recorded a Greensfield's Driveometer. Control affected by but effects were not same; speed faster during weaving less.
Hindbrain catecholaminergic (CA) neurons are required for critical autonomic, endocrine, and behavioral counterregulatory responses (CRRs) to hypoglycemia. Recent studies suggest that CRR initiation depends on hindbrain astrocyte glucose sensors (McDougal DH, Hermann GE, Rogers RC. Front Neurosci 7: 249, 2013; RC, Ritter S, GE. Am J Physiol Regul Integr Comp 310: R1102-R1108, 2016). To test the proposition CA glucoprivation dependent, we utilized transgenic mice in which calcium reporter...
Objective This study aimed to investigate a novel approach for determining the effects of energy‐standardized dinner meals (high‐fat and low‐fat) on respiratory exchange ratio (RER) dynamics metabolic flexibility. Methods Using randomized crossover design, energy expenditure, RER, macronutrient oxidation rates were assessed in response single meal during an overnight stay whole‐body room calorimeter. Eight healthy adults completed two chamber stays while fed either high‐fat (60% fat, 20%...
Tuxen, D. V.; Sutton, J.; Upton, A.; Sexton, McDougal, D.; Sale, Author Information