A5056001929- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- Pancreatic function and diabetes
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Kruppel-like factors research
- Birth, Development, and Health
- Regulation of Appetite and Obesity
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Muscle metabolism and nutrition
- Insect and Arachnid Ecology and Behavior
- Plant and animal studies
- Neuroscience of respiration and sleep
- Reproductive Physiology in Livestock
- Neuropeptides and Animal Physiology
- Diabetes Treatment and Management
- Biochemical Analysis and Sensing Techniques
- Genetic Syndromes and Imprinting
- Growth Hormone and Insulin-like Growth Factors
- Connective tissue disorders research
- Genetic and phenotypic traits in livestock
- Endoplasmic Reticulum Stress and Disease
- Animal Behavior and Welfare Studies
University of Potsdam
2021-2023
Pennington Biomedical Research Center
2013-2020
German Center for Diabetes Research
2017-2020
German Institute of Human Nutrition
2017-2020
Heinrich Heine University Düsseldorf
2017-2020
Deutsches Diabetes-Zentrum e.V.
2017-2020
Saarland University
2016
Louisiana State University System
2016
University of Pennsylvania
2014
Research Institute for Farm Animal Biology (FBN)
2013-2014
Enhanced fibroblast growth factor 21 (FGF21) production and circulation has been linked to the metabolic adaptation starvation. Here, we demonstrated that hepatic FGF21 expression is induced by dietary protein restriction, but not energy restriction. Circulating was increased 10-fold in mice rats fed a low-protein (LP) diet. In these animals, liver Fgf21 within 24 hours of reduced intake. humans, circulating levels dramatically following 28 days on LP LP-induced increases were associated...
Reduced dietary protein intake induces adaptive physiological changes in macronutrient preference, energy expenditure, growth, and glucose homeostasis. We demonstrate that deletion of the FGF21 co-receptor βKlotho (Klb) from brain produces mice are unable to mount a response restriction, an effect is replicated by whole-body FGF21. Mice forced consume low-protein diet exhibit reduced increased resistance diet-induced obesity, but loss signaling completely abrogates response. When given...
FGF21 contributes to the metabolic response dietary protein restriction, and prior data implicate GCN2 as amino acid sensor linking restriction induction. Here, we demonstrate persistent essential role of in restriction. We show that Fgf21 KO mice are fully resistant low (LP)-induced changes food intake, energy expenditure (EE), body weight gain, gene expression for 6 months. Gcn2 recapitulate this phenotype, but LP-induced effects on EE, subsequently begin appear after 14 days diet. delayed...
Increased hepatic expression of dipeptidyl peptidase 4 (DPP4) is associated with non-alcoholic fatty liver disease (NAFLD). Whether this causative for the development NAFLD not yet clarified. Here we investigate effect DPP4 overexpression on steatosis in a mouse model diet-induced obesity.
Dietary protein restriction increases adipose tissue uncoupling 1 (UCP1), energy expenditure and food intake, these effects require the metabolic hormone fibroblast growth factor 21 (FGF21). Here we test whether induction of during requires UCP1, promotes a resistance to cold stress, is dependent on concomitant hyperphagia. Wildtype, Ucp1-KO Fgf21-KO mice were placed control low (LP) diets assess changes in expenditure, intake other endpoints. Deletion Ucp1 blocked LP-induced exacerbated...
Dietary methionine restriction (MR) is well known to reduce body weight by increasing energy expenditure (EE) and insulin sensitivity. An elevated concentration of circulating fibroblast growth factor 21 (FGF21) has been implicated as a potential underlying mechanism. The aims our study were test whether dietary MR in the context high-fat regimen protects against type 2 diabetes mice investigate vegan vegetarian diets, which have naturally low levels, modulate FGF21 humans. New Zealand obese...
Fibroblast growth factor 21 (FGF21) is considered to be a promising therapeutic candidate for the treatment of type 2 diabetes. However, as FGF21 levels are elevated in obese and diabetic conditions we aimed test if exogenous sufficient prevent diabetes beta cell loss New Zealand (NZO) mice, model polygenetic obesity diabetes.Male NZO mice were treated with specific dietary regimen that leads onset within 1 week. Mice subcutaneously PBS or assess changes glucose homeostasis, energy...
Intracerebroventricular injections of leucine are sufficient to suppress food intake, but it remains unclear whether brain signaling represents a physiological signal protein balance. We tested variations in dietary and circulating levels leucine, or all three branched-chain amino acids (BCAAs), contribute the detection reduced protein. Of essential (EAAs) tested, only intracerebroventricular injection (10 μg) was intake. Isocaloric low- (9% energy; LP) normal- (18% energy) diets induced...
Abstract The relationship between levels of dominance and species richness is highly contentious, especially in ant communities. dominance‐impoverishment rule states that high only occur species‐poor communities, but there appear to be many cases diverse extent which dominant limit local through competitive exclusion remains unclear, such appears more apparent for non‐native rather than native species. Here we perform the first global analysis behavioral richness. We used data from 1,293...
What forces structure ecological assemblages? A key limitation to general insights about assemblage is the availability of data that are collected at a small spatial grain (local assemblages) and large extent (global coverage). Here, we present published unpublished from 51 ,388 ant abundance occurrence records more than 2,693 species 7,953 morphospecies local assemblages 4,212 locations around world. Ants were selected because they diverse abundant globally, comprise fraction animal biomass...
β-Hydroxybutyric acid (BHBA) acts in the brain to influence feeding behaviour, but underlying molecular mechanisms are unclear. GT1-7 hypothalamic cells expressing orexigenic agouti-related peptide (AGRP) were used study AMP-activated protein kinase (AMPK) pathway known integrate dietary and hormonal signals for food intake regulation. In a 25 mM glucose culture medium, BHBA increased intracellular calcium concentrations expression of monocarboxylate transporter 1 (MCT1 (SLC16A1))....
Non-alcoholic fatty liver diseases (NAFLD) including the severe form with steatohepatitis (NASH) are highly prevalent ailments to which no approved pharmacological treatment exists. Dietary intervention aiming at 10% weight reduction is efficient but fails due low compliance. Increase in physical activity an alternative that improved NAFLD even absence of reduction. The underlying mechanisms unclear and cannot be studied humans. Here, a rat model was developed reproduces many facets...
Low-protein diets are well known to improve glucose tolerance and increase energy expenditure. Increases in circulating fibroblast growth factor 21 (FGF21) have been implicated as a potential underlying mechanism. We aimed test whether low-protein the context of high-carbohydrate or high-fat regimen would also protect against type 2 diabetes New Zealand Obese (NZO) mice used model polygenetic obesity diabetes. Mice were placed on that provided protein at control (16 kJ%; CON) low (4...
Hormone secretion from metabolically active tissues, such as pancreatic islets, is governed by specific and highly regulated signaling pathways. Defects in insulin are among the major causes of diabetes. The molecular mechanisms underlying are, however, not yet completely understood. In this work, we studied role GTPase ARFRP1 on β-cells. A β-cell-specific Arfrp1 knockout mouse was phenotypically characterized. Pulldown experiments mass spectrometry analysis were employed to screen for new...
Housing in metabolic cages can induce a pronounced stress response. Metabolic cage systems imply housing mice on metal wire mesh for the collection of urine and feces addition to monitoring food water intake. Moreover, are single-housed, no nesting, bedding, or enrichment material is provided, which often argued have not negligible impact animal welfare due cold stress. We therefore attempted reduce during by comparing an innovative (IMC) with commercially available from Tecniplast GmbH...
After parturition, feed intake of dairy cows increases within the first weeks lactation, but molecular mechanisms stimulating or delaying slope increase are poorly understood. Some molecules controlling neuropeptides that synthesized as propeptides and subsequently processed before they bind to specific receptors in feeding centers brain. Cerebrospinal fluid surrounds most regulatory contains numerous neuropeptides. In present study, we used a proteomic approach analyze neuropeptide...