A5100634832- Plant Physiology and Cultivation Studies
- Horticultural and Viticultural Research
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Postharvest Quality and Shelf Life Management
- Nanoplatforms for cancer theranostics
- Plant-derived Lignans Synthesis and Bioactivity
- Phytochemistry and Biological Activities
- Photodynamic Therapy Research Studies
- Drug Transport and Resistance Mechanisms
- Cancer Treatment and Pharmacology
- Plant Micronutrient Interactions and Effects
- Biological Activity of Diterpenoids and Biflavonoids
- Traditional Chinese Medicine Analysis
- Natural product bioactivities and synthesis
- Dermatologic Treatments and Research
- Engineering Structural Analysis Methods
- Drug-Induced Hepatotoxicity and Protection
- Vibration and Dynamic Analysis
- Immunotherapy and Immune Responses
- Plant Pathogens and Fungal Diseases
- Phytochemistry and Bioactive Compounds
- Plant Reproductive Biology
- Advanced biosensing and bioanalysis techniques
- Phytochemical compounds biological activities
Institute of Materials and Environmental Chemistry
2025
China General Nuclear Power Corporation (China)
2022-2024
Zhejiang University
2005-2024
China Agricultural University
2024
Harbin Engineering University
2023
Jiaxing University
2009-2021
State Key Laboratory of Silkworm Genomic Biology
2021
Southwest University
2021
Innovation Team (China)
2021
Sun Yat-sen University
2012-2017
Here, a biodegradable polymer–drug conjugate of doxorubicin (DOX) conjugated with stearic acid-grafted chitosan oligosaccharide (CSO-SA) was synthesized via disulfide linkers. The obtained DOX-SS-CSO-SA could self-assemble into nanosized micelles in aqueous medium low critical micelle concentration. size the 62.8 nm narrow distribution. In reducing environments, rapidly disassemble result from cleavage linkers and release DOX. had high efficiency for cellular uptake released DOX reductive...
Background: Solid tumors need new blood vessels to feed and nourish them as well allow tumor cells escape into the circulation lodge in other organs, which is termed "angiogenesis." Some within solid can overexpress integrins α v β 3 5 , specifically recognize peptide motif Arg-Gly-Asp (RGD). Thus, targeting of RGD-modified micelles vasculature a promising strategy for tumor-targeting treatment. Methods: RGD (GSSSGRGDSPA) was coupled poly(ethylene glycol)-modified stearic acid-grafted...
Redox-responsive nanomaterials applied in drug delivery systems (DDS) have attracted an increasing attention pharmaceutical research as a carrier for antitumor therapy. However, there would be unwanted release from redox-responsive DDS with no selection at nontarget sites, leading to undesirable toxicities normal tissues and cells. Here, A54 peptide modified PEGylated reduction cleavable glucolipid conjugate (A54-PEG-CSO-ss-SA, abbreviated APCssA) was designed intracellular of doxorubicin...
O-aminophenol oxidases, a specialized subclass of type-III copper proteins, play crucial role in the biosynthesis bioactive nitrosophenols which display antiretroviral and blood cholesterol lowering activity. Another related tyrosinases, closely resemble o-aminophenol oxidases both structurally enzymatically but lack their unique ability to oxidize o-aminophenols into nitrosophenols. To unpuzzle catalytic disparities subclasses, highly conserved amino acid residues vicinity center were...
O‐aminophenol oxidases, a specialized subclass of type‐III copper proteins, play crucial role in the biosynthesis bioactive nitrosophenols which display antiretroviral and blood cholesterol lowering activity. Another related tyrosinases, closely resemble o‐aminophenol oxidases both structurally enzymatically but lack their unique ability to oxidize o‐aminophenols into nitrosophenols. To unpuzzle catalytic disparities subclasses, highly conserved amino acid residues vicinity center were...
Metastasis is one of the major obstacles for successful therapy breast tumor. To inhibit metastasis and growth tumor simultaneously, a Celastrol (Cela) loaded glucolipid-like conjugates (CSOSA/Cela) with αvβ3-ligand Tetraiodothyroacetic acid (TET) modification (TET-CSOSA/Cela) were established to block nuclear factor-kappa B (NF-κB) signaling pathway. The distribution TET-CSOSA was remarkably increased in lung primary 4T1 tumor-bearing mice by means αvβ3 receptor-mediated interaction....
Development of successful formulations for poorly water-soluble drugs remains a longstanding critical and challenging issue in cancer therapy. The stearic acid-g-chitosan oligosaccharide (CSO-SA) micelles have been presented as potential candidates intracellular antitumour agent delivery carrier. Herein, podophyllotoxin (PPT) loaded CSO-SA (CSO-SA/PPT) were prepared by dialysis method. drug encapsulation efficiency could reach higher level, the micellar size zeta increased with increasing...
SERPINA3K, also known as kallikrein-binding protein (KBP), is a serine proteinase inhibitor with anti-inflammatory and anti-angiogenic activities. Our previous studies showed that SERPINA3K inhibited proliferation in dose-dependent manner induced apoptosis of endothelial cells but had no influence on SGC-7901 gastric carcinoma or HepG2 hepatocarcinoma cells. However, it unknown whether has direct impact other which mechanisms are involved. In this study, we report for the first time not only...
Polyethylenimine (PEI) is considered to be a promising non-viral gene delivery vector. To solve the toxicity versus efficacy and tumor-targeting challenges of PEI used as vector, we constructed novel vector DR5-TAT-modified Pluronic-PEI (Pluronic-PEI-DR5-TAT), which was based on attachment low-molecular-weight polyethylenimine (LMW-PEI) amphiphilic polymer Pluronic prepare Pluronic-modified LMW-PEI (Pluronic-PEI). This then conjugated multifunctional peptide containing cell-penetrating (TAT)...
Oncological photodynamic therapy (PDT) relies on photosensitizers (PSs) to photo-oxidatively destroy tumor cells. Currently approved PSs yield satisfactory results in superficial and easy-to-access tumors but are less suited for solid cancers internal organs such as the biliary system pancreas. For these malignancies, second-generation metallated phthalocyanines more appropriate. Presently it is not known which of commonly employed phtahlocyanines, namely aluminum phthalocyanine (AlPC) zinc...
Introduction: Long non-coding RNA (lncRNA) refers to a category of molecules exceeding 200 nucleotides in length, which exerts regulatory role the context ovarian development. There is paucity research examining involvement lncRNA regulation ovary development Taihe Black-Bone Chickens. In order further investigate egg laying mechanisms Chickens at different periods, transcriptome analysis was conducted on tissues periods. Methods: This study randomly selected from 12 chickens for RNA-seq....
The purpose of this study was to prepare and characterize emodin-loaded stearic acid-g-chitosan oligosaccharide (CSO-SA/EMO) evaluate its antitumor activity in vitro. In study, used as a carrier physicochemical properties were determined by different methods. Cell uptake behavior examined using FITC-labeled oligosaccharide. CSO-SA/EMO prepared ultrasonication dialysis. Particle size, surface potential, entrapment efficiency, drug release studied effects on gastric cancer cells investigated...
SUMMARY The first dog-associated outbreak of rabies in swine China (Hunan province) has been diagnosed and the related virus isolated. Sequence analysis showed that pig isolate was a genotype 1 with very high nucleotide identity to local dog isolates.
By the regulation of fruit ripening we ensure consumers have a year-round supply with acceptable eating quality and health promoting components. Fruit is highly regulated process coordinated genetic metabolic events, leading to essential changes in gene expression, physiology, biochemistry anatomy. These complex regulatory events transform physiologically mature but inedible into an edible, tasty product. Molecular analysis development especially ripening, has resulted confirmed gains...
A modification of CSOSA micelles with BKT-140 increased receptor-mediated cell uptake and anti-metastasis effect in the CXCR4 high expressing cells.
Low-oxygen and/or high-carbon dioxide injury result from holding apples and pears in atmospheres below/above their tolerance for oxygen/carbon levels. The incidence extent of the disorders are influenced by concentration carbon oxygen duration exposure as well site conditions, cultivar, fruit maturity, storage temperature humidity. Cultivars individual fruits vary susceptibility to because anatomical differences (size intercellular space, rate gas diffussion tissue through skin) biochemical...
SummaryInternal flesh browning and cavities frequently occur in 'Conference' pears during controlled atmosphere (CA)-storage, particularly under high CO2 or low O2 partial pressures, both. Boron (B) appears to alleviate the occurrence of injuries. In three consecutive years, effects pre-harvest B application, alone combined with calcium (Ca), were assessed on several physiological parameters pear fruit stored conditions.'Conference' trees sprayed up six-times before harvest, without...
Chlorines are attractive compounds for photodynamic therapy because of their high absorption in the red wavelength region. The stearic acid-grafted chitosan oligosaccharide (CSO-SA) micelles have been presented as potential candidates intracellular drug delivery carrier special structure. In this study, CSO-SA were prepared to encapsulate chlorine e6 (Ce6). physicochemical properties synthesized characterized. critical micelle concentration (CMC) with 4.96% amino substituted degree (SD %)...
Sweet (Prunus avium L.) and sour cherries cerasus are two economically important species in Europe. The capability to distinguish among cherry cultivars breeding, cultivation germplasm collection is extremely for scientific as well economic reasons. Normally morphological traits used identify but these often differently expressed different environments production practices. Our objective was, parallel the usual identifying methods, fingerprint a subset of 43 sweet- 30 with 15 SSR primers,...