A5013126524- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Microfluidic and Capillary Electrophoresis Applications
- Cancer-related Molecular Pathways
- Microfluidic and Bio-sensing Technologies
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Integrated Energy Systems Optimization
- FOXO transcription factor regulation
- Human Health and Disease
- Lung Cancer Diagnosis and Treatment
- Microtubule and mitosis dynamics
- Process Optimization and Integration
- Hydrocarbon exploration and reservoir analysis
- Histone Deacetylase Inhibitors Research
- 3D Printing in Biomedical Research
- Coal Properties and Utilization
- RNA Interference and Gene Delivery
- Cancer Immunotherapy and Biomarkers
- Electrospun Nanofibers in Biomedical Applications
- Epigenetics and DNA Methylation
- Smart Grid Energy Management
- ATP Synthase and ATPases Research
- Immune Cell Function and Interaction
- Pancreatic function and diabetes
Shanghai Jiao Tong University
2023
China University of Mining and Technology
2023
Stony Brook University
2019-2021
Capital Medical University
2015-2016
Beijing Chest Hospital
2016
Zhejiang University
2015
Institute of Microelectronics
2008-2009
Singapore Science Park
2009
Agency for Science, Technology and Research
2008
Here, a biodegradable polymer–drug conjugate of doxorubicin (DOX) conjugated with stearic acid-grafted chitosan oligosaccharide (CSO-SA) was synthesized via disulfide linkers. The obtained DOX-SS-CSO-SA could self-assemble into nanosized micelles in aqueous medium low critical micelle concentration. size the 62.8 nm narrow distribution. In reducing environments, rapidly disassemble result from cleavage linkers and release DOX. had high efficiency for cellular uptake released DOX reductive...
Abstract Enormous efforts have been made to target metabolic dependencies of cancer cells for developing new therapies. However, the therapeutic efficacy glycolysis inhibitors is limited due their inability elicit cell death. Hexokinase 2 (HK2), via its mitochondrial localization, functions as a central nexus integrating activation and apoptosis resilience. Here we identify that K63-linked ubiquitination by HectH9 regulates localization function HK2. Through stable isotope tracer approach...
Triple-negative breast cancer (TNBC) is the most aggressive subtype of that harbors enriched stem cell (CSC) populations in tumors. Conventional chemotherapy a standard treatment for TNBC, but it spares CSC populations, which cause tumor recurrence and progression. Therefore, identification core molecular pathway controls activity expansion essential developing effective therapeutics TNBC. In this study, we identify USP2 deubiquitinating enzyme upregulated CSCs novel regulator CSCs. Genetic...
Studies have found that hypoxia is the most common feature in all of solid tumor progression, thus it has become a central issue physiology and cancer treatment. Hypoxia-inducible factor-1α (HIF-1α) could make produce adaptive biological response to more aggressive. In this paper, we used enzyme linked immune sorbent assay detect plasma level HIF-1α patients with NSCLC healthy volunteers. The results indicated 5-year survival rate squamous cell carcinomas negatively correlated low higher...
Article3 March 2021Open Access Transparent process MIG-6 is essential for promoting glucose metabolic reprogramming and tumor growth in triple-negative breast cancer Jiabei He orcid.org/0000-0002-7363-6101 Department of Pharmacological Sciences, Stony Brook University, Brook, NY, USA Search more papers by this author Chien-Feng Li orcid.org/0000-0002-9527-7576 National Institute Cancer Research, Health Research Institutes, Tainan, Taiwan Pathology, Chi-Mei Foundational Medical Center,...
The ubiquitin ligase RNF8 is known to induce epithelial-to-mesenchymal (EMT) transition and metastasis in triple-negative breast cancer (TNBC). Besides EMT, Rho GTPases have been shown as key regulators metastasis. In this study, we investigated the role of regulating cell motility. We find that knockdown TNBC cells attenuates protein mRNA levels Ras homolog family member A (RHOA) division cycle 42 (CDC42). show formation filopodia, focal adhesions, association adhesions stress fibers...
A lab-on-a-chip microfluidic device was designed, fabricated, and tested to be used in cancer cell or disease detection body fluids. Mixtures of breast cells MCF-7 control MCF-10A were captured by meandering weir filters channels. selective fluorescent complex 17β-estradiol-bovine serum albumin-fluorescein isothiocyanate enabled specifically detect after only 4 min contact. These signals are about seven times stronger than that a labeling performed on conventional glass slides following the...
A biomicrofluidic device and a compact cellular testing system were developed to be used in cancer diagnostics. The was fabricated by lithography-based microfabrication techniques, followed two-step etching of deep reactive ion etching, channels formed anodic bonding Si Pyrex. is based on the capture cells inside new meandering weir-type filter design, detection characterization using specific fluorescent labeling. Breast MCF-7 control MCF-10A flowed through microfluidic channels, captured...
Integrated energy system (IES) has been widely used in the field of supply due to high efficiency utilization. However, its economic operation is challenged by different uncertainties system. This paper establishes a multi-stage robust optimization model for IES with both decision-independent (DIUs) and decision-dependent (DDUs). Because some are affected decision, such as price, they modeled DDUs. To solve complicated scheduling problem DDUs, an improved column-and-constraint generation...
Our study uncovered that HectH9 drives glycolysis and tumor development by K63-linked ubiquitination of Hexokinase 2 (HK2). This mechanism is critical for HK2 localization to mitochondria activating HK2's functions in promotion apoptosis inhibition, suggesting targeting a new strategy tackle metabolism-addicted tumors.
Abstract Treatment of triple-negative breast cancer (TNBC) remains challenging due to a lack effective targeted therapies. Dysregulated glucose uptake and metabolism are essential for TNBC growth. Identifying the molecular drivers mechanisms underlying metabolic vulnerability is key exploiting dysregulated therapeutic applications. Mitogen-inducible gene-6 (MIG-6) has long been thought as feedback inhibitor that targets activated EGFR suppresses growth tumors driven by constitutive mutant...
Treatment of triple-negative breast cancer (TNBC) remains challenging due to a lack effective targeted therapies. Dysregulated glucose uptake and metabolism are essential for TNBC growth. Identifying the molecular drivers mechanisms underlying metabolic vulnerability is key exploiting dysregulated therapeutic applications. Mitogen-inducible gene-6 (MIG-6) has long been thought as feedback inhibitor that targets activated EGFR suppresses growth tumors driven by constitutive mutant EGFR. Here,...