A5101910957- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Neuroblastoma Research and Treatments
- Cancer Cells and Metastasis
- Herpesvirus Infections and Treatments
- Cancer Research and Treatments
- interferon and immune responses
- Cancer, Hypoxia, and Metabolism
- Virus-based gene therapy research
- Immune cells in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer-related Molecular Pathways
- Heart Rate Variability and Autonomic Control
- Pharmacological Effects of Natural Compounds
- Bone and Dental Protein Studies
- Traditional Chinese Medicine Studies
- Biochemical effects in animals
- Cytokine Signaling Pathways and Interactions
- FOXO transcription factor regulation
- Biochemical Analysis and Sensing Techniques
- Bacterial Infections and Vaccines
- Ion channel regulation and function
- Forest Insect Ecology and Management
Ruijin Hospital
2025
Shanghai Jiao Tong University
2025
Nanfang Hospital
2008-2024
Southern Medical University
2008-2024
Shandong University of Traditional Chinese Medicine
2009-2024
Guangdong Pharmaceutical University
2024
Guangdong Medical College
2024
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2022-2024
South China University of Technology
2021-2024
Tianjin First Center Hospital
2024
Abstract Background The transcription factor HOXD9 is one of the members HOX family, which plays an important role in neoplastic processes. However, growth and metastasis gastric cancer (GC) remains to be elucidated. Methods In vitro functional RURY3 GC cells was determined using TMA-based immunohistochemistry, western blot, EdU incorporation, gelatin zymography, luciferase, chromatin Immunoprecipitation (ChIP) cell invasion assays. vivo tumor were conducted nude mice. Results overexpressed...
Abstract In pneumonia, the deficient or delayed pathogen clearance can lead to proliferation and subsequent overactive immune responses, inducing acute lung injury (ALI). While screening human genome coding genes using our peripheral blood cell chemotactic platform, we unexpectedly find SLP adaptor CSK interacting membrane protein (SCIMP), a with neutrophil activity secreted during ALI. However, specific role of SCIMP in ALI remains unclear. this study, investigate secretion exosomes (SCIMP...
Laccase, a member of group proteins collectively known as multicopper oxidases, is hypothesized to play an important role in insect cuticle sclerotization by oxidizing catechols the their corresponding quinones, which then catalyze protein cross-linking reactions. Laccase 2 has been proved gene required for beetle tanning through RNA interference (RNAi) experiments on red flour Tribolium castaneum. The pine sawyer beetle, Monochamus alternatus (Coleoptero: Cerambycidae) serving major vector...
Low-grade pro-inflammatory state and leptin resistance are important underlying mechanisms that contribute to obesity-associated hypertension. We tested the hypothesis Astragaloside IV (As IV), known counteract obesity hypertension, could prevent hypertension by inhibiting reaction resistance. High-fat diet (HFD) induced obese rats were randomly assigned three groups: HFD control group (HF con group), As group, + α-bungaratoxin (α-BGT) IV+α-BGT group). (20 mg·Kg
Centromere protein U (CENPU), a centromere-binding required for cellular mitosis, has been reported to be closely associated with carcinogenesis in multiple malignancies; however, the role of CENPU hepatocellular carcinoma (HCC) is still unclear.Herein, we investigated its biological and molecular mechanism development HCC.High expression HCC tissue was observed correlated positively poor prognosis patients.CENPU knockdown inhibited proliferation, metastasis, G1/S transition cells vivo...
Abstract Background Acute gout arthritis (AGA) is a common metabolic joint disease and urgently needs safer alternative therapy due to the significant side effects from long-term use of primary medications. Folium Hibisci Mutabilis , traditional medicinal herb, has demonstrated promising therapeutic efficacy in clinical management AGA, but its pharmacological mechanisms remain be elucidated. Methods Mutabili was isolated refined into Extract (FHME). Then, monosodium urate-induced AGA animal...
Accumulating studies have demonstrated the abnormal expressions and prognostic values of certain members tripartite motif (TRIM) family in diverse cancers. However, comprehensive TRIM hepatocellular carcinoma (HCC) are yet to be clearly defined.The were evaluated by survival analysis univariate Cox regression based on gene expression data clinical HCC from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. profiles, protein-protein interaction among family, prediction...
Huangqi Guizhi Wuwu decoction (HQGZWWD) is a traditional Chinese herbal medicine formulation with significant anti-inflammatory activity. However, its underlying mechanism remains unknown. Through network pharmacology and experimental validation, this study aimed to examine the potential of HQGZWWD in regulating macrophage polarization inflammation.The active components were obtained from Traditional Medicine Systems Pharmacology database Analysis Platform (TCMSP), whereas corresponding...
Neuroblastoma (NB) is one of the deadliest paediatric solid tumours due to its rapid proliferative characteristics. Amplified copies MYCN are considered most important marker for prediction tumour relapse and progression in NB, but they were only detected 20-30% NB patients, indicating there might be other oncogenes development NB. The far upstream element binding protein 1 (FUBP1) was first identified as a transcriptional regulator proto-oncogene MYC. However, expression role FUBP1 have not...
Nasopharyngeal carcinoma (NPC) is a type of epithelial malignancy known for its high likelihood metastasizing to distant organs, which remains the primary obstacle in treatment NPC. The present study aimed identify potential intervention target NPC metastasis.
Background/Aims: Metastasis is the primary cause of colorectal cancer (CRC)-related death. However, molecular mechanisms underlying metastasis in CRC remain unclear. Methods: We evaluated mRNA and protein expression levels by quantitative real-time reverse transcription PCR, western blotting, immunofluorescence, tissue microarrays, immunohistochemistry assays. also assessed migration invasion abilities cells vitro wound healing assays, blot analysis, immunofluorescence. Tumor was nude mice...
Nasopharyngeal carcinoma (NPC) is an epithelial malignancy ubiquitously associated with Epstein-Barr virus (EBV). EBV generates various viral microRNAs (miRNAs) by processing the BHRF1 and BamHI A rightward (BART) transcripts. These BART miRNAs are abundantly expressed in NPC, but their functions molecular mechanisms remain largely unknown. Our study found that EBV-encoded microRNA BART-22 was significantly upregulated NPC tissues positively correlated tumor progression. Furthermore, we...
Alzheimer's disease (AD) is the most common cause of dementia. Pigment epithelium-derived factor (PEDF), a unique neurotrophic protein, decreases with aging. Previous reports have conflicted regarding whether PEDF concentration altered in AD patients. In addition, effect on has not been documented. Here, we tested serum samples 31 patients and 271 normal controls. We found that compared to levels young middle-aged control subjects, were reduced old-aged controls even more so Furthermore,...
Abstract Gastric cancer (GC) constitutes substantial mortality worldwide. Several types aberrantly express bone marrow stromal cell antigen 2 (BST2), yet its functional and underlying mechanisms in GC progression remain unknown. In our study, RNA sequencing data revealed that BST2 was transcriptionally activated by homeobox D9 (HOXD9). significantly upregulated tissues promoted epithelial–mesenchymal transition metastasis of GC. knockdown reversed HOXD9's oncogenic effect on metastasis....
Distant metastasis is the primary cause of nasopharyngeal carcinoma (NPC) treatment failure while epithelial-mesenchymal transition (EMT) critical process NPC invasion and metastasis. However, tumor-suppressor genes involved in EMT have not been explored clearly compared with oncogenes. In present study, expression pigment epithelium-derived factor (PEDF), a potent endogenous antitumor factor, was diminished human tissues associated clinicopathological features. The knockdown PEDF induced...
Background/Aims: The CCDC43 gene is conserved in human, rhesus monkey, mouse and zebrafish. Bioinformatics studies have demonstrated the abnormal expression of colorectal cancer (CRC). However, role molecular mechanism CRC remain unknown. Methods: functional FOXK1 epithelial-mesenchymal transition (EMT) was determined using immunohistochemistry, flow cytometry, western blot, EdU incorporation, luciferase, chromatin Immunoprecipitation (ChIP) cell invasion assays. Results: overexpressed human...
Sarcopenia is linked to an unfavorable prognosis in individuals with rheumatoid arthritis (RA). Early identification and treatment of sarcopenia are clinically significant. This study aimed create validate a nomogram for predicting risk RA patients, providing clinicians reliable tool the early high-risk patients.