A5101536162- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Cancer-related gene regulation
- Head and Neck Cancer Studies
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Probabilistic and Robust Engineering Design
- Cancer-related molecular mechanisms research
- Lanthanide and Transition Metal Complexes
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Electrocatalysts for Energy Conversion
- Ionic liquids properties and applications
- Neuroscience and Neuropharmacology Research
- Sulfur Compounds in Biology
- Memory and Neural Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Metal-Organic Frameworks: Synthesis and Applications
- MicroRNA in disease regulation
- Acoustic Wave Phenomena Research
- Traffic control and management
- Vehicle Noise and Vibration Control
- Protease and Inhibitor Mechanisms
- Minerals Flotation and Separation Techniques
- Thermal and Kinetic Analysis
Guangzhou Medical University
2012-2025
State Key Laboratory of Respiratory Disease
2019-2024
Lanzhou Jiaotong University
2023-2024
Chengdu University of Traditional Chinese Medicine
2024
Xiamen University
2023-2024
City University of Macau
2022-2024
Qingdao National Laboratory for Marine Science and Technology
2024
Ocean University of China
2024
Central South University
2022-2024
China Agricultural University
2024
Abstract The biological role of miR-500a-5p has not yet been reported in the context colorectal cancer (CRC). Here, we show that expression is decreased CRC tissues compared with adjacent normal tissues. Low associated malignant progression. Moreover, transfection cells induces G0/G1 cell cycle arrest and inhibits their growth migration. Mechanistically, directly targets HDAC2 HDAC2-mediated proliferation nude mice. Furthermore, YY1 binds to promoter negatively regulates its transcription....
MiR-646 has been reported to be aberrantly expressed in human cancers. However, the underlying molecular mechanisms of action miR-646 gastric cancer (GC) have not yet investigated.In vitro function GC was evaluated using EdU assay, plate colony formation and matrigel invasion assay. Real-time PCR or western blotting performed detect FOXK1 expressions. In vivo tumour growth metastasis were conducted nude mice.MiR-646 expression downregulated tissues compared with adjacent normal tissues. Low...
We previously found that the disorder of soluble epoxide hydrolase (sEH)/cyclooxygenase-2 (COX-2)-mediated arachidonic acid (ARA) metabolism contributes to pathogenesis non-alcoholic fatty liver disease (NAFLD) in mice. However, exact mechanism has not been elucidated. Accumulating evidence points essential role cellular senescence NAFLD. Herein, we investigated whether restoring balance sEH/COX-2-mediated ARA attenuated NAFLD via hepatocyte senescence. A promised dual inhibitor sEH and...
Abstract Background Stroke is a major cause of mortality and long-term disability worldwide. Whether the associations between brain imaging-derived phenotypes (IDPs) stroke are causal uncertain. Methods We performed two-sample bidirectional Mendelian randomization (MR) analyses to explore IDPs stroke. Summary data 587 (up 33,224 individuals) from UK Biobank five types (sample size range 301,663 446,696, case number 5,386 40,585) MEGASTROKE consortium were used. Results Forward MR indicated...
Abstract Forkhead box (FOX) K1 is a member of the FOX transcription factor superfamily. High FOXK1 expression associated with several cancers. However, whether contributes to gastric cancer (GC) development and progression remains unknown. We analyzed promoter using Promo software found binding sequence factors, including c-jun. molecular mechanism by which affects c-jun-mediated malignant phenotype poorly understood. Here, we that protein was higher in 8/10 (80.0%) fresh tissues compared...
Polo-like kinase 1 (PLK1) is a protein that overexpressed in breast cancer and may represent an attractive target for treatment. However, few studies have investigated the relationship between PLK1 radiosensitivity cancer. Here, we attempted to explore whether inhibition could sensitize cells radiation.
Tanshinone-IIA (Tan-IIA), a primary active component extracted from commonly used Chinese herbal, Salvia miltiorrhiza (Danshen), is considered as potential inhibitor against tumor cell proliferation. However, the application of Tan-IIA hindered by its poor water solubility and low bioavailability. In this work, an imidazole moiety was linked to skeleton enhance antitumor activity. A series Tan-IIA-based analogues TA01–TA12 were synthesized, their inhibitory activities migration invasion...
Molecular probes suitable for different fluorescence imaging technologies can meet the requirements of scientific research in biological applications. In this work, a naphthalimide-cyanine-based sulfonamide was used to specifically visualize glutathione mouse tissues with two-photon manner naphthalimide moiety and near-infrared cyanine moiety, respectively. The results showed that probe served as dual-model tissue-imaging agent visualization around 200 μm depth 120 manner, which provided...