A5039113890- Antifungal resistance and susceptibility
- Pneumonia and Respiratory Infections
- Fungal Infections and Studies
- Polysaccharides and Plant Cell Walls
- Microbial Metabolites in Food Biotechnology
- Immune Response and Inflammation
- Gut microbiota and health
- Bacterial Infections and Vaccines
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Asthma and respiratory diseases
- Phagocytosis and Immune Regulation
- Streptococcal Infections and Treatments
- Polysaccharides Composition and Applications
- Seaweed-derived Bioactive Compounds
- Neonatal Respiratory Health Research
- Mitochondrial Function and Pathology
- Urticaria and Related Conditions
- Cancer-related molecular mechanisms research
- Genetic Neurodegenerative Diseases
- Algal biology and biofuel production
- Autophagy in Disease and Therapy
- Respiratory and Cough-Related Research
- Allergic Rhinitis and Sensitization
- Cell Adhesion Molecules Research
- Immune cells in cancer
Tufts University
2020-2025
Binzhou University
2024-2025
Binzhou Medical University
2024-2025
Ocean University of China
2025
Jinan University
2024
Nanjing University of Chinese Medicine
2023-2024
Massachusetts General Hospital
2018-2022
Shantou University
2017-2020
Zhongshan Hospital of Xiamen University
2020
Xiamen University
2020
Huntington’s disease (HD) arises from the abnormal expansion of CAG repeats in huntingtin gene (HTT), resulting production mutant protein (mHTT) with a polyglutamine stretch its N-terminus. The pathogenic mechanisms underlying HD are complex and not yet fully elucidated. However, mHTT forms aggregates accumulates abnormally neuronal nuclei processes, leading to disruptions multiple cellular functions. Although there is currently no effective curative treatment for HD, significant progress...
Significance The elderly exhibit susceptibility to many infectious agents, including S. pneumoniae . A robust acute inflammatory response is associated with severe disease. triggers canonical autophagy in nonprofessional phagocytes, but its role macrophages largely unexplored. We found that BMDMs utilize LAP, rather than autophagy, both eliminate and modulate inflammation. Notably, compared young BMDMs, aged were deficient resulting compromised bacterial killing enhanced proinflammatory...
Neoagaro-oligosaccharides (NAOS) have health benefits that are related to their amount and degree of polymerization (DP). However, the current methods used quantify enzymatically released NAOS un-specific time-consuming. Agar has been extracted from Gelidium amansii degraded by AgaXa (a recombinant β-agarase). Polysaccharide analysis using carbohydrate gel electrophoresis (PACE) adapted in order NAOS. In addition, anti-oxidant activity samples assessed. We found PACE method provided...
Invasive fungal infections due to Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans constitute a substantial threat hospitalized immunocompromised patients. Further, the presence of drug-recalcitrant biofilms on medical devices emergence drug-resistant fungi, such as auris, introduce treatment challenges with current antifungal drugs. Worse, currently there is no approved drug capable obviating preformed biofilms, which increase chance infection relapses. Here, we screened...
Neutrophils are recognized to represent significant immune cell mediators for the clearance and elimination of human-pathogenic fungal pathogen Candida . The sensing fungi by innate cells is performed, in part, through lectin receptor recognition wall components downstream cellular activation signaling components, including spleen tyrosine kinase (Syk). While essential role Syk macrophages dendritic clear, there remains uncertainty with respect its contribution neutrophils. In this study, we...
ABSTRACT Streptococcus pneumoniae ( Sp ; pneumococcus), the most common agent of community‐acquired pneumonia, can spread systemically, particularly in elderly, highlighting need for adjunctive therapies. The airway epithelial barrier defends against bacteremia and is dependent upon apical junctional complex (AJC) proteins such as E‐cadherin. After mouse lung challenge, pneumolysin (PLY), a key virulence factor, stimulates secretion an inflammatory eicosanoid, triggering infiltration...
BG136, a β-1,3/1,6-glucan derived from Durvillaea antarctica, is an injectable anticancer drug and has entered Phase II clinical trials. Rational oral formulation design pivotal focus for our future development research; therefore, elucidating the gastrointestinal fate of BG136 becomes imperative. This study investigated stability biotransformation via in vitro digestion gut microbiota fermentation. The results confirmed BG136’s structural integrity, resistance to degradation highly acid...
β-glucan, a promising drug candidate for immuno-antitumor therapy, holds tremendous potential clinical applications. However, the absence of highly sensitive quantitative methods polysaccharides, attributed to their complicated chemical structures and susceptibility endogenous interference, has posed significant challenges development. Here, we report reliable analytical strategy quantifying β-1, 3/1, 6-glucan derived from Durvillaea antarctica (BG136) in various biological matrices. This...
Tetraspanins are a family of proteins possessing four transmembrane domains that help in lateral organization plasma membrane proteins. These interact with each other as well receptors and signaling proteins, resulting functional complexes called "tetraspanin microdomains." Tetraspanins, including CD82, play an essential role the pathogenesis fungal infections. Dectin-1, receptor for cell wall carbohydrate β-1,3-glucan, is vital to host defense against The current study identifies novel...
Streptococcus pneumoniae, a common cause of community-acquired bacterial pneumonia, can cross the respiratory epithelial barrier to lethal septicemia and meningitis. S. pneumoniae pore-forming toxin pneumolysin (PLY) triggers robust neutrophil (PMN) infiltration that promotes transepithelial migration in vitro disseminated disease mice. Apical infection polarized monolayers by at multiplicity (MOI) 20 resulted recruitment PMNs, loss 50% monolayer, PMN-dependent translocation. Reducing MOI 2...
ABSTRACT Streptococcus pneumoniae ( Sp ), a leading cause of community-acquired pneumonia, can spread from the lung into bloodstream to septicemia and meningitis, with concomitant threefold increase in mortality. Limitations vaccine efficacy rise antimicrobial resistance have spurred searches for host-directed therapies that target pathogenic immune processes. Polymorphonuclear leukocytes (PMNs) are essential infection control but also promote tissue damage pathogen spread. The major...
The tetraspanin CD82 is a potent suppressor of tumor metastasis and regulates several processes including signal transduction, cell adhesion, motility, aggregation. However, the mechanisms by which participates in innate immunity are unknown. We report that key regulator TLR9 trafficking signaling. recognizes unmethylated cytosine-phosphate-guanine (CpG) motifs present viral, bacterial, fungal DNA. demonstrate associate macrophages, occurs endoplasmic reticulum (ER) post-ER. Moreover,...
Abstract Background Elucidating the mechanism of macrophage phagocytic response will improve our knowledge host defence against Treponema pallidum . Objective To explore whether autophagy promotes T. phagocytosis and clearance via NLRP3 inflammasome in macrophages. Methods The interactions between role these processes ‐treated macrophages were investigated through experiments using human monocytic cell line (THP‐1)‐derived after was evaluated by inoculating rabbits with macrophage–treponeme...
Candida spp. are the fourth leading cause of nosocomial blood stream infections in North America. glabrata is second most frequently isolated species, and rapid development antifungal resistance has made treatment a challenge. In this study, we investigate therapeutic potential metformin, biguanide with well-established action for diabetes, as an agent against C. glabrata. Both wild type antifungal-resistant isolates were subjected to biguanide-antifungal combination treatment. Metformin,...