A5100691857- Circadian rhythm and melatonin
- Neurobiology and Insect Physiology Research
- Prostate Cancer Treatment and Research
- Cancer-related gene regulation
- T-cell and B-cell Immunology
- Single-cell and spatial transcriptomics
- Wnt/β-catenin signaling in development and cancer
- Genetics, Aging, and Longevity in Model Organisms
- Invertebrate Immune Response Mechanisms
- Estrogen and related hormone effects
- Congenital Diaphragmatic Hernia Studies
- Insect symbiosis and bacterial influences
- Spaceflight effects on biology
- Reproductive Biology and Fertility
- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- Domain Adaptation and Few-Shot Learning
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Neural Network Applications
- Medical Imaging and Pathology Studies
- Immunotherapy and Immune Responses
- Genomics and Chromatin Dynamics
- Atherosclerosis and Cardiovascular Diseases
- Receptor Mechanisms and Signaling
Fudan University
2025
Wuhan University
2024
National Institute of Biological Sciences, Beijing
2019-2023
Tsinghua University
2019-2021
Taiyuan University of Technology
2020
Southern Medical University
2013
To gain mechanistic insights into the functions and developmental dynamics of tumor-infiltrated immune cells, especially B-lymphocytes, here we combine single-cell RNA-sequencing antigen receptor lineage analysis to characterize a large number triple-negative breast cancer infiltrated cells report comprehensive atlas B-lymphocytes. The transcriptional profiles reveal significant heterogeneity in B-cell subgroups. analyses demonstrate that compared with those peripheral blood, B-cells have...
Abstract Twenty-nine years following the breakthrough discovery that a single-gene mutation of daf-2 doubles Caenorhabditis elegans lifespan, it remains unclear where this insulin/IGF-1 receptor gene is expressed and acts to regulate ageing. Using knock-in fluorescent reporters, we determined its downstream transcription factor daf-16 are ubiquitously. tissue-specific targeted protein degradation, intracellular DAF-2-to-DAF-16 signaling in intestine plays major role lifespan regulation,...
Abstract Wnt/β‐catenin signaling and its dysregulation play critical roles in stem cell fate determination the pathology of various diseases. However, application translated Wnt ligand regenerative medicine is hampered by hydrophobicity cross‐reactivity with Frizzled (FZD) receptors. Here, a synthetic key receptor modulator, FZD agonist RRP‐pbFn generated, for high‐efficiency activation absence direct binding to LRP5/6. demonstrates superior potency compared surrogate Wnt, supporting growth...
A compound that disassembles the circadian repressive super-complex can reset phase and relieve jet lag in mice.
The Qinghai-Tibet Plateau (QTP) harbors hundreds of species well adapted to its extreme conditions, including low-oxygen (hypoxic) atmosphere. Here, we show that the plateau pika—a keystone mammal QTP—lacks robust circadian rhythms. major form pika Epas1 protein includes a 24-residue insert caused by point mutation at 5′ juncture site Intron14 and is more stable than other mammalian orthologs. Biochemical studies reveal an Epas1-Bmal1 complex with lower trans-activation activity occupies...
Postoperative cognitive dysfunction (POCD) is a central nervous system complication that occurs after anesthesia, particularly among the elderly. However, neurological pathogenesis of postoperative remains unclear. The aim this study was to evaluate effects sevoflurane exposure on serum metabolites and hippocampal gene expression in elderly patients aging mice by metabolomics transcriptomic analysis explore induced POCD.
Androgen receptor (AR) is expressed in both the prostate epithelium and stroma plays diverse roles physiology. Although low expression of stromal AR clinically associated with advanced cancer stage worse outcome, whether inhibits or promotes progression remains controversial. Here, we specifically delete smooth muscle cells adult mouse under two tumorigenic conditions, namely, Hi-Myc genetic model T + E2 hormonal carcinogenesis model. Histology analyses show that deletion exacerbates tumor...
Intestinal stem cells (ISCs) are able to generate gut-specific enterocytes, as well neural-like enteroendocrine cells. It is unclear how the tissue identity of ISC lineage regulated confer cell-lineage fidelity. Here, we show that, in adult Drosophila midgut, loss transcriptional repressor Tramtrack ISCs causes a self-renewal program switch neural cell (NSC)-like, and that drives neuroendocrine tumor development. In Tramtrack-depleted ISCs, ectopically expressed Deadpan acts major factor for...
The task of distinguishing types tumors in brain MRI scans is paramount importance the medical field. In recent years, deep learning methods have produced leaps advancements, especially field computer vision, which allowed to address important challenges such as image classification rise convolutional neural networks brought about achievement new heights many tasks, include analysis. They very good results terms accuracy and performances, by recognizing repeating patterns shapes a image,...
Both the canonical Wnt and androgen receptor (AR) signaling pathways are important for prostate organogenesis homeostasis. How they crosstalk to regulate stem cell behaviors remains unclear. Here, we show in lineage-tracing mouse models that although is essential basal multipotency, ectopic activity promotes over-proliferation squamous phenotypes, which counteracted by elevated levels of androgen. In organoids, dihydrotestosterone (DHT) antagonizes R-spondin-stimulated growth a...
Abstract While it has been well-recognized that T-cell mediated adaptive cellular immunity plays important roles in cancer immune response and tumor control, the of B lymphocytes development therapy have only proposed until recently, are still mostly controversial. To gain mechanistic insights into origin dynamics infiltrated cells, especially lymphocytes, we combine single-cell RNA-sequencing antigen receptor lineage analysis to characterize a large number triple-negative breast (TNBC)...
Abstract Both the canonical Wnt signaling and androgen are important factors regulating prostate organogenesis. How these two pathways crosstalk to regulate stem cell functions remain unclear. Here, we show that while activity is required for basal multipotency in vivo, ectopic does not promote basal-to-luminal differentiation. We provide evidence may keep check. In organoid culture from cells, dihydrotestosterone (DHT) antagonizes R-spondin-stimulated growth a concentration-dependent...
Summary Twenty-eight years following the breakthrough discovery that a single-gene mutation of daf-2 can double lifespan Caenorhabditis elegans , it remains unclear where this gene, which encodes an insulin/IGF-1 receptor, is expressed and acts to regulate aging. Here, by inserting DNA sequences fluorescent tags into genomic locus its downstream transcription factor daf-16 we determined both genes are in most or all tissues from embryos through adulthood, line with their diverse functions....
Enteroendocrine cells (EEs) in the intestinal epithelium have important endocrine functions, yet this cell lineage exhibits great local and regional variations that hampered detailed characterization of EE subtypes. Through single RNA-sequencing analysis, combined with a collection neuropeptide/receptor knock-in strains, here we provide comprehensive analysis cellular diversity, spatial distribution transcription factor (TF) code EEs adult Drosophila midgut. We identify 10 major subtypes...
Abstract Meiosis is essential for fertility in sexually reproducing species, extensive studies tried to delineate this sophisticated process. Notwithstanding, the molecules involved meiosis have not been fully characterized. In study, we investigate role of zinc finger protein 541 (ZFP541) and its interacting potassium channel tetramerization domain containing 19 (KCTD19) mice. We demonstrate that they are indispensable male by regulating proper pachytene progression. ZFP541 expressed...