A5081502147- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Crystallization and Solubility Studies
- Animal Behavior and Reproduction
- X-ray Diffraction in Crystallography
- Spinal Cord Injury Research
- Circadian rhythm and melatonin
- Invertebrate Immune Response Mechanisms
- Insect Utilization and Effects
- Toxoplasma gondii Research Studies
- CRISPR and Genetic Engineering
- Botulinum Toxin and Related Neurological Disorders
- Nerve Injury and Rehabilitation
- Computational Drug Discovery Methods
- Cerebral Palsy and Movement Disorders
- Genetics, Bioinformatics, and Biomedical Research
- Peroxisome Proliferator-Activated Receptors
- Nerve injury and regeneration
- Crystallography and molecular interactions
- Parasitic Infections and Diagnostics
- Cytomegalovirus and herpesvirus research
- Photoreceptor and optogenetics research
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Plant and animal studies
Tsinghua University
2023-2025
Center for Life Sciences
2017-2024
Chinese Institute for Brain Research
2017-2024
Beijing University of Chinese Medicine
2023-2024
Sophia University
2024
Peking University
2017-2024
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2020-2024
State Key Laboratory of Tribology
2024
McGovern Institute for Brain Research
2023-2024
Capital Medical University
2023-2024
Enteroendocrine cells (EEs) in the intestinal epithelium have important endocrine functions, yet this cell lineage exhibits great local and regional variations that hampered detailed characterization of EE subtypes. Through single-cell RNA-sequencing analysis, combined with a collection peptide hormone receptor knockin strains, here we provide comprehensive analysis cellular diversity, spatial distribution, transcription factor (TF) code EEs adult Drosophila midgut. We identify 10 major...
Our understanding of the molecular mechanisms underlying sleep homeostasis is limited. We have taken a systematic approach to study neural signaling by transmitter 5-hydroxytryptamine (5-HT) in drosophila. generated knockout and knockin lines for Trh, 5-HT synthesizing enzyme all five receptors, making it possible us determine their expression patterns investigate functional roles. Loss 5HT1a or 5HT2b gene decreased time whereas loss Trh diminished rebound after deprivation. small subset of,...
Aggressive behavior is regulated by various neuromodulators such as neuropeptides and biogenic amines. Here we found that the neuropeptide Drosulfakinin (Dsk) modulates aggression in Drosophila melanogaster. Knock-out of Dsk or receptor CCKLR-17D1 reduced aggression. Activation inactivation Dsk-expressing neurons increased decreased male aggressive behavior, respectively. Moreover, data from transsynaptic tracing, electrophysiology behavioral epistasis reveal function downstream a subset P1...
Abstract Circadian rhythms are orchestrated by a master clock that emerges from network of circadian pacemaker neurons. The is synchronized to external light/dark cycles through photoentrainment, but the circuit mechanisms underlying visual photoentrainment remain largely unknown. Here, we report Drosophila has eye-mediated via parallel neuron organization. Patch-clamp recordings central neurons reveal light excites most them independently one another. We also show light-responding send...
The tetramethylpyrazine-loaded conductive hydrogel could diminish the breakdown of blood–spinal cord barrier and protect against neuronal cell death to synergistically restore neurological functions post spinal injury.
By binding to the adaptor protein SKP1 and serving as substrate receptors for Cullin, F-box E3 ubiquitin ligase complex, proteins regulate critical cellular processes including cell cycle progression membrane trafficking. While are conserved throughout eukaryotes well studied in yeast, plants, animals, studies parasitic protozoa lagging. We have identified eighteen putative Toxoplasma genome of which four predicted homologs Plasmodium. Two were demonstrated be important fitness here we focus...
Female sexual behavior as an innate is of prominent biological importance for survival and reproduction. However, molecular circuit mechanisms underlying female not well understood. Here, we identify the Cholecystokinin-like peptide Drosulfakinin (DSK) to promote in Drosophila. Loss DSK function reduces receptivity while overexpressing enhances receptivity. We two pairs Dsk-expressing neurons central brain find that acts through one its receptors, CCKLR-17D3, modulate Manipulation CCKLR-17D3...
Accepting or rejecting a mate is one of the most crucial decisions female will make, especially when faced with food shortage. Previous studies have identified core neural circuity from sensing male courtship mating status to decision-making for sexual receptivity in Drosophila females, but how hunger and satiety states modulate poorly understood. Here, we identify circuit its neuromodulation underlying modulation receptivity. We find that adipokinetic hormone receptor (AkhR)-expressing...
The choice of females to accept or reject male courtship is a critical decision for animal reproduction. Serotonin (5-hydroxytryptamine; 5-HT) has been found regulate sexual behavior in many species, but it unclear how 5-HT and its receptors function different aspects behavior. Here we used Drosophila melanogaster as the model investigate modulate female receptivity. We that knockout tryptophan hydroxylase (Trh), which involved biosynthesis 5-HT, severely reduced virgin receptivity without...
Polycomb and Trithorax group (PcG TrxG) genes function to regulate gene transcription by maintaining a repressive or active chromatin state, respectively. This antagonistic activity is important for body patterning during embryonic development, but whether this module has role in adult tissues unclear. Here, we report that the Drosophila ovary, disruption of complex 1 (PRC1), specifically supporting escort cells, causes blockage cystoblast differentiation germline stem cell-like tumor...
To explore the mechanisms for repairing spinal cord injury (SCI) with tetramethylpyrazine-loaded electroconductive hydrogel (hereinafter referred to as "TGTP").
Abstract Female sexual receptivity is essential for reproduction of a species. Neuropeptides play the main role in regulating female receptivity. However, whether neuropeptides regulate during neurodevelopment unknown. Here we found peptide hormone prothoracicotropic (PTTH), which belongs to insect PG axis, negatively regulated virgin through ecdysone Drosophila melanogaster . We identified PTTH neurons as doublesex-positive neurons, they before metamorphosis 3 rd -instar larval stage....
To investigate the neuroprotective effect of conducting hydrogel loaded with tetramethylpyrazine sustained-release microparticles (hereinafter referred to as "TGTP hydrogel") on spinal cord injury rats.Forty-eight adult female Sprague Dawley rats were randomly divided into 4 groups: sham operation group (group A), model B), conductive C), and TGTP D), 12 in each group. Only laminectomy was performed A, complete transection groups B, C, D. Basso-Bettie-Bresnahan (BBB) score used evaluate...