A5025249597- Toxoplasma gondii Research Studies
- Trypanosoma species research and implications
- Biochemical and Molecular Research
- Autophagy in Disease and Therapy
- Heme Oxygenase-1 and Carbon Monoxide
- Parasitic Infections and Diagnostics
- Mosquito-borne diseases and control
- Neonatal Health and Biochemistry
- Porphyrin Metabolism and Disorders
- Bipolar Disorder and Treatment
- Herpesvirus Infections and Treatments
- Polyamine Metabolism and Applications
- HIV/AIDS drug development and treatment
- Research on Leishmaniasis Studies
- Cytomegalovirus and herpesvirus research
- HIV Research and Treatment
- Ubiquitin and proteasome pathways
Laboratoire de Biochimie
2025
Institute of Biomedical Science
2025
Universidade de São Paulo
2015-2025
University at Buffalo, State University of New York
2019-2025
Virginia Tech
2024
Plasmodium species replicate via schizogony, which involves asynchronous nuclear divisions followed by semi-synchronous segmentation and cytokinesis. Successful requires a double-membranous structure known as the inner membrane complex (IMC). Here we demonstrate that PfFBXO1 (PF3D7_0619700) is critical for both asexual gametocyte maturation. In Toxoplasma gondii, FBXO1 homolog, TgFBXO1, essential development of daughter cell scaffold component IMC. We forming similar IMC initiation near...
l-Serine and l-threonine have versatile roles in metabolism. In addition to their use protein synthesis, these amino acids participate the biosynthesis pathways of other even phospholipids. Furthermore, l-serine can be substrates for a serine/threonine dehydratase (Ser/ThrDH), resulting pyruvate 2-oxobutyrate, respectively, thus being with anaplerotic potential. Trypanosoma cruzi, etiological agent Chagas disease, uses several biological processes: metacyclogenesis, infection, resistance...
By binding to the adaptor protein SKP1 and serving as substrate receptors for Cullin, F-box E3 ubiquitin ligase complex, proteins regulate critical cellular processes including cell cycle progression membrane trafficking. While are conserved throughout eukaryotes well studied in yeast, plants, animals, studies parasitic protozoa lagging. We have identified eighteen putative Toxoplasma genome of which four predicted homologs Plasmodium. Two were demonstrated be important fitness here we focus...
ABSTRACT Toxoplasma gondii is an apicomplexan parasite that the cause of toxoplasmosis, a potentially lethal disease for immunocompromised individuals. During in vivo infection, parasites encounter various growth environments, such as hypoxia. Therefore, metabolic enzymes must adapt to changes fulfill their nutritional requirements. can de novo biosynthesize some nutrients, heme. The heavily rely on own heme production intracellular survival. Notably, antepenultimate step within this pathway...
Toxoplasma gondii is a foodborne pathogen that can cause severe and life-threatening infections in fetuses immunocompromised patients. Felids are its only definitive hosts, wide range of animals, including humans, serve as intermediate hosts. When the transmissible bradyzoite stage orally ingested by felids, they transform into merozoites expand asexually, ultimately generating millions gametes for parasite sexual cycle. However, bradyzoites hosts differentiate exclusively to disease-causing...
is an obligate intracellular parasite whose tachyzoite form causes disease via a lytic growth cycle. Its metabolic and cellular pathways are primarily designed to ensure survival within host cell. But during its cycle, tachyzoites exposed the extracellular milieu prolonged exposure requires activation of stress response that include reprogramming proteome. Regulation protein synthesis therefore important for survival. We previously reported in extracellularly stressed parasites, elongation...
Nucleotide sugar transporters (NSTs) play an essential role in translocating nucleotide sugars into the lumen of endoplasmic reticulum and Golgi apparatus to be used as substrates glycosylation reactions. This intracellular transport is step biosynthesis glycoconjugates. We have identified a family 11 putative NSTs Trypanosoma cruzi, etiological agent Chagas’ disease. A UDP-N-acetylglucosamine transporter, TcNST1, was by yeast complementation approach. Based on phylogenetic analysis four...
ABSTRACT l -Serine ( -Ser) and l- Threonine Thr) have versatile roles in metabolism. In addition to their use protein synthesis, these amino acids participate the biosynthesis pathways of other even phospholipids. Furthermore, -Ser Thr can be substrates for a Ser/Thr dehydratase (Ser/ThrDH), resulting pyruvate (Pyr) 2-oxobutyrate, respectively, thus being with anaplerotic potential. Trypanosoma cruzi , etiological agent Chagas disease, uses several biological processes: metacyclogenesis,...
ABSTRACT Toxoplasma gondii is a foodborne pathogen that can cause severe and life-threatening infections in fetuses immunocompromised patients. Felids are its only definitive hosts, wide range of animals, including humans, serve as intermediate hosts. When the transmissible bradyzoite stage orally ingested by felids, they transform into merozoites expand asexually, ultimately generating millions gametes for parasite sexual cycle. However, bradyzoites hosts differentiate exclusively to...
ABSTRACT Toxoplasma gondii is an apicomplexan parasite that the cause of toxoplasmosis, a potentially lethal disease for immunocompromised individuals. During in vivo infection, parasites encounter various growth environments, such as hypoxia. Therefore, metabolic enzymes must adapt to changes fulfill their nutritional requirements. can de novo biosynthesize some nutrients, heme. The heavily rely on own heme production intracellular survival. Notably, antepenultimate step within this pathway...
ABSTRACT Toxoplasma gondii is an obligate intracellular parasite whose tachyzoite form causes disease via a lytic growth cycle. Its metabolic and cellular pathways are primarily designed to ensure survival within host cell. But during its cycle tachyzoites exposed the extracellular milieu prolonged exposure requires activation of stress response that include reprogramming proteome. Regulation protein synthesis therefore important for survival. We previously reported in extracellularly...
ABSTRACT By binding to the adaptor protein SKP1 and serving as substrate receptors for Skp1, Cullin, F-box E3 ubiquitin ligase complex, proteins regulate critical cellular processes including cell cycle progression membrane trafficking. While are conserved throughout eukaryotes well studied in yeast, plants, animals, studies parasitic protozoa lagging. We have identified eighteen putative Toxoplasma genome of which four predicted homologs Plasmodium . Two were demonstrated be important...