A5100411291- CAR-T cell therapy research
- Acute Lymphoblastic Leukemia research
- Renal cell carcinoma treatment
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Anesthesia and Sedative Agents
- Mitochondrial Function and Pathology
- RNA Interference and Gene Delivery
- ATP Synthase and ATPases Research
- Autophagy in Disease and Therapy
- Nausea and vomiting management
- Renal Transplantation Outcomes and Treatments
- Anesthesia and Pain Management
- Hematopoietic Stem Cell Transplantation
- Ferroptosis and cancer prognosis
- Circadian rhythm and melatonin
- Intensive Care Unit Cognitive Disorders
- Cancer-related molecular mechanisms research
- Hemoglobinopathies and Related Disorders
- Respiratory Support and Mechanisms
- Renal Diseases and Glomerulopathies
- Spinal Fractures and Fixation Techniques
- PARP inhibition in cancer therapy
- Prostate Cancer Treatment and Research
Dalian Medical University
2019-2024
Chongqing Medical University
2019-2024
Second Affiliated Hospital of Chongqing Medical University
2019-2024
First Affiliated Hospital Zhejiang University
2020-2024
Eighth Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen University
2024
Xinxiang Central Hospital
2024
Shanxi Medical University
2023
Harbin Medical University
2023
Zhejiang University
2022-2023
Abstract Background Cerebral ischemia-reperfusion injury (CIRI) refers to a secondary brain that can occur when the blood supply ischemic tissue is restored. However, mechanism underlying such remains elusive. Methods The 150 male C57 mice underwent middle cerebral artery occlusion (MCAO) for 1 h and reperfusion 24 h, Among them, 50 MCAO were further treated with Mitochondrial division inhibitor (Mdivi-1) N-acetylcysteine (NAC). SH-SY5Y cells cultured in low-glucose culture medium 4 under...
Sepsis is a dysregulated response to infection that can result in life-threatening organ failure, and septic cardiomyopathy serious complication involving ferroptosis. Olaparib, classic targeted drug used oncology, has demonstrated potential protective effects against sepsis. However, the exact mechanisms underlying its action remain be elucidated. In our study, we meticulously screened ferroptosis genes associated with sepsis, conducted comprehensive functional enrichment analyses delineate...
Septic cardiomyopathy (SCM) is associated with an imbalance in mitochondrial quality and high mortality rates, no effective treatment developed to date. Curcumin provides antioxidant, anti-inflammatory, cardiovascular, protection. However, curcumin has not been confirmed improve cardiac dysfunction sepsis. We hypothesized that can reduce abnormal inflammatory responses by improving function as a novel mechanism SCM. To explore this hypothesis, we used vivo male C57BL/6 mouse sepsis model...
Objectives Esketamine is an S (+) enantiomer of ketamine with greater potency and similar psychomimetic effects compared to racemic ketamine. We aimed explore the safety esketamine in different doses as adjuvant propofol patients undergoing endoscopic variceal ligation (EVL) or without injection sclerotherapy. Methods One hundred were randomized receive sedation 1.5 mg/kg combination sufentanil 0.1 μg/kg (group S), 0.2 E0.2), 0.3 E0.3), 0.4 E0.4) for EVL ( n = 25 each). Hemodynamic...
Excessive mitochondrial fission following ischemia and hypoxia relies on the formation of contacts between endoplasmic reticulum mitochondria (ER-Mito); however, specific mechanisms behind this process remain unclear. Confocal microscopy time course recording are used to investigate how affect activation dynamin-related protein 1 (Drp1), a central dynamics, ER-Mito interactions, consequences modifying expression Drp1, shroom (Shrm) 4, inverted formin (INF) 2 contact establishment. Both Drp1...
Context Sepsis can result in critical organ failure, and notoginsenoside R1 (NGR1) offers mitochondrial protection.
Purpose: Ischemic stroke is a high-incidence disease that threatens human well-being. The potent neuroprotective effects render reactive oxygen species (ROS) scavengers potential agents for acute ischemic therapy. Challenges such as inadequate permeability across the blood-brain barrier (BBB), limited half-life, and adverse hinder widespread utilization of small molecule inorganic ROS scavengers. Thus, there an urgent demand efficacious targeting stroke. Our study discovered superoxide...
Importance The effect of high-intensity noninvasive positive pressure ventilation (NPPV) on the need for endotracheal intubation in patients with an acute exacerbation chronic obstructive pulmonary disease (COPD) is unknown. Objective To determine whether use NPPV vs low-intensity reduces COPD and hypercapnia. Design, Setting, Participants Randomized clinical trial conducted at 30 general respiratory non–intensive care unit wards Chinese hospitals from January 3, 2019, to 31, 2022; last...
Abstract Background Female sex workers (FSWs) are at high risk of chlamydia infection, yet the seroprevalence among FSWs in China remains unclear. This study aimed to determine Chlamydia trachomatis and associated factors Guangdong Province, China. Methods A cross-sectional was conducted two cities Province. Participants provided serum urine samples. Nucleic acid amplification test (NAAT) used detect (CT) Neisseria gonorrhoeae (NG) Enzyme-linked immunosorbent assay (ELISA) IgG antibodies...
The Qinghai-Tibet Plateau (QTP) harbors hundreds of species well adapted to its extreme conditions, including low-oxygen (hypoxic) atmosphere. Here, we show that the plateau pika—a keystone mammal QTP—lacks robust circadian rhythms. major form pika Epas1 protein includes a 24-residue insert caused by point mutation at 5′ juncture site Intron14 and is more stable than other mammalian orthologs. Biochemical studies reveal an Epas1-Bmal1 complex with lower trans-activation activity occupies...
Calcific aortic valve stenosis (CAVS) is the most common heart disorder among humans. To date, no effective method has been identified to prevent this disease. Herein, we aimed identify novel diagnostic and mitochondria-related biomarkers of CAVS, based on two machine learning algorithms. We further explored their association with infiltrating immune cells studied potential function in CAVS. The GSE12644, GSE51472, GSE83453 expression profiles were downloaded from Gene Expression Omnibus...
Introduction Accurate and accessible predictors of chronic postsurgical pain (CPSP) to identify high-risk patients are prerequisite for preventive interventional strategies. We investigated the incidence risk factors CPSP after abdominal surgery, with a focus on plasma immunological markers. Materials methods This was retrospective analysis who underwent surgery under general anesthesia at tertiary center between January 2021 2022. The preoperative demographics, laboratory test data,...
Abstract Allogeneic hematopoietic cell transplantation (allo‐HCT) is recommended for core‐binding factor mutated (CBF) AML patients achieving second complete remission (CR2). However, approximately 20% of may relapse after transplant and donor preference remains unclear. We compared in this EBMT global multicenter registry‐based analysis the allo‐HCT outcomes using either haploidentical (Haplo), matched siblings donors (MSD), or 10/10 unrelated (MUD). Data from 865 de novo adult CBF CR2...
Objective. This study is aimed at identifying the potential diagnostic markers for circulating endothelial cells (CECs) acute myocardial ischemia (AMI) and exploring regulatory mechanisms of selected biomarker in mitochondrial oxidative damage vascular inflammation AMI pathology. Methods. Utilizing Gene Expression Omnibus dataset GSE66360, we scanned differentially expressed genes (DEGs) 49 patients 50 healthy subjects. To discover possible biomarkers, LASSO regression support vector machine...
Long-term artificial sweetener intake is linked to increased risk of obesity. In the present study, supplement natural from Siraitia grosvenorii (SG) (or Momordica grosvenorii) fruit, compared with aspartame (ASM), was evaluated for anti-obesity effects on mice fed high fat diet (HFD). We found that, in contrary ASM, SG extracts prevented body weight gain, insulin resistance and mass accumulation HFD mice. treatment inhibited infiltration inflammatory macrophages lowered levels cytokines...
The relationship between marine polyunsaturated fatty acid (PUFA) intake and cardiovascular disease mortality in dyslipidemic patients is unclear. Men with dyslipidemia have a higher risk of than women, PUFA supplementation may be more beneficial men. purpose this study was to assess the different types acids intakes disease, all-cause mortality, adult U.S. males dyslipidemia. ultimately included 11,848 men who were screened from National Health Nutrition Examination Survey (NHANES) 2001...
BackgroundPain management after lung resection plays a crucial role in reducing postoperative pulmonary complications (PPCs). This study aimed to examine the effect of esketamine infusion as an adjunct opioid analgesia on ventilation and patients underwent resection.MethodsPatients undergoing video-assisted thoracoscopic were randomly assigned either group or control group. The received 24-h 1.5 mcg/ml sufentanil combined with 0.75 surgery, while alone. primary outcome measure was low minute...
Abstract Focus on the implications of common perioperative drugs for mitochondrial quality control and their subsequent impact overall physiological condition has been increasing. This review discusses effects drugs, such as intravenous inhaled anesthetics, analgesics, local anesthetics underlying mechanisms. These influence properties, including morphology, dynamics, energy metabolism, protein expression, thereby affecting clinical outcomes patients undergoing surgery. Such can be either...
Hypovolemia is common in colonoscopy due to fasting and bowel preparation, propofol itself can reduce systemic vascular resistance, resulting relative hypovolemia. Therefore, hypotension not a rare event during propofol-based sedation for colonoscopy.