A5014909771- Gut microbiota and health
- Prostate Cancer Diagnosis and Treatment
- Urologic and reproductive health conditions
- Animal Nutrition and Physiology
- Genomics, phytochemicals, and oxidative stress
- Prostate Cancer Treatment and Research
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Essential Oils and Antimicrobial Activity
- Vitamin C and Antioxidants Research
- Pharmacological Effects of Natural Compounds
- Radio Astronomy Observations and Technology
- Neuroinflammation and Neurodegeneration Mechanisms
- Ginseng Biological Effects and Applications
- Abdominal Trauma and Injuries
- Circular RNAs in diseases
- Ovarian cancer diagnosis and treatment
- Intraperitoneal and Appendiceal Malignancies
- Lung Cancer Research Studies
- Amoebic Infections and Treatments
- Autophagy in Disease and Therapy
- Axon Guidance and Neuronal Signaling
- Stress Responses and Cortisol
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
Xiaomi (China)
2025
Beijing Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
Tianjin Normal University
2012-2022
Nanjing University of Chinese Medicine
2018-2020
Peking Union Medical College Hospital
2017-2020
Clostridium butyricum (CB) can enhance antioxidant capacity and alleviate oxidative damage, but the molecular mechanism by which this occurs remains unclear. This study used enterotoxigenic Escherichia coli (ETEC) K88 as a pathogenic model, p62-Keap1-Nrf2 signaling pathway intestinal microbiota starting point to explore through CB alleviates damage. After pretreatment with for 15 d, mice were challenged ETEC 24 h. The results suggest that dramatically reduce crypt depth (CD) significantly...
•We conducted prostate autopsies to investigate latent cancer epidemiology and measure the accuracy of biopsy.•In recent decades, prevalence has increased in China.•Transperineal transrectal biopsies exhibited similar sensitivities but different preferential areas.•Both methods biopsy missed one-third cases with large lesions, most which were anterior prostate. Prostate detected by autopsy is named cancer. As repertoire clinical cancer, may better reflect disease burden. Unlike specimens,...
Salmonella enterica Serovar Typhimurium (S. Typhimurium) infection can cause inflammation and oxidative stress in the body, leading to gastroenteritis, fever other diseases humans animals. More more studies have emphasized broad prospects of probiotics improving stress, but ability mechanism Lactobacillus acidophilus (LA) alleviate inflammatory/oxidative reaction caused by pathogens are still unclear. In this study, we treated mice with LA for 14 days, infected them S. 24 h, sacrificed...
Black hole masses are estimated for radio-loud quasars using several self-consistent scaling relationships based on emission-line widths and continuum luminosities. The emission lines used, Hβ, Mg ii λ2798 C iv λ1549, have different dependencies orientation as by radio core dominance. We compare differences in the log of black from show that they depend dominance sense core-dominated, jet-on objects systematically smaller Hβ determined compared to those iv, while lobe-dominated edge-on...
Baicalin isolated from Scutellaria baicalensis possesses antidepressant abilities through its relation to hippocampal neurogenesis. Current research has found that baicalin can promote the proliferation of granule cells, however, detailed mechanism on survival and maturation cells yet be sufficiently explored. The purpose this study was evaluate whether could facilitate explore potential mechanism. chronic corticosterone (CORT)-induced mouse model depression used assess antidepressant-like...
Background: Whether the probiotic Clostridium butyricum (CB) alleviates enterotoxigenic Escherichia coli (ETEC) K88-induced inflammation by regulating activation of toll-like receptor (TLR) signaling pathway is not clear, thus, we carried out this study. A total 72 piglets (average body weight 7.09 ± 0.2 kg) were randomly divided into three groups 24 per group. Pigs either fed a daily diet (NC, negative control), tested every day 1 × 10 9 CFU/mL ETEC K88 (PC, positive or basal supplemented...
Clostridium butyricum (CB) is a naturally occurring probiotic compound that can alleviate the oxidative damage induced by enterotoxigenic Escherichia coli K88 (ETEC K88) in porcine intestinal epithelial (IPEC-J2) cells. In this study, we investigate molecular mechanism underlying effect. Based on cell viability, malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPX) assessments, optimal concentration of ETEC was determined to be 1 × 103 cfu/mL. Viable bacteria counts...
Abstract Endometrial cancer (EC) constitutes a common female genital tract tumor with rising incidence rate. Sirtuin 1 (SIRT1) is member of histone deacetylase, which extensively participates in the progression aging, cell death, and tumorigenesis. This study explored effect SIRT1‐mediated LC3 acetylation on autophagy proliferation EC cells. SIRT1 expression tissues adjacent tissues, lines normal human epithelial cells was detected. elevated tissues. Knockdown inhibited proliferation,...
The emergence and spread of antibiotic resistance genes in pathogenic microorganisms have resulted many countries restricting the use antibiotics as growth promoters animal feed. combined essential oils organic acids can help maintain intestinal health, improve performance, alleviate negative effects banned for certain economically important animals. Although modes action dietary supplementation such thymol-citric acid (EOA1) thymol-butyric (EOA2) remain unclear, it is speculated that their...
Despite the availability of numerous treatment options, managing patients with platinum-resistant ovarian cancer (PROC) remains challenging, and prognosis PROC is notably unfavorable. This retrospective study aimed to assess efficacy safety combined anlotinib-oral etoposide for PROC.
Abstract Background The characteristics of prostate cancer on autopsy and early‐stage are identical. Using specimens, we analysed clarified the spatial distributions lesions. Method We obtained specimens from Chinese donors without a diagnosis analyzed pathological by whole‐mount sampling. determined lesions in horizontal vertical dimensions. dimension included four quadrants (left‐anterior, left‐posterior, right‐anterior, right‐posterior quadrants), peripheral zone, transition zone. Result...
Abstract Salmonella , a pathogenic gram-negative bacterium, has been reported to cause intestinal inflammatory response, which is found in both humans and animals. However, the underlying mechanism not quite clear. To this end, we used typhimurium (ST)-infected mice or epithelioid cell line 6 (IEC-6 cells) as model explore roles of ST reducing response elucidate potential mechanisms. In vivo experiments, were given with different concentrations (2.5×10 cfu/mL, 2.5×10 7 cfu/mL 8 cfu/mL). The...
Abstract Background: The emergence and spread of antibiotic resistance genes in pathogenic microorganisms have led to many countries enacting restricted use antibiotics as growth promoters animal feed. combined essential oils organic acids can help maintain intestinal health, improve performance, alleviate the negative effects banned for certain economically important animals. However, modes action dietary supplementation (thymol-citric acid; EOA1, thymol-butyric EOA2) remain unclear,...