A5100761592- Prenatal Screening and Diagnostics
- Genomic variations and chromosomal abnormalities
- Genetic Syndromes and Imprinting
- Pregnancy and preeclampsia studies
- Assisted Reproductive Technology and Twin Pregnancy
- Fetal and Pediatric Neurological Disorders
- Congenital heart defects research
- Congenital Heart Disease Studies
- Parvovirus B19 Infection Studies
- RNA modifications and cancer
- Adrenal and Paraganglionic Tumors
- Renal and related cancers
- Prostate Cancer Treatment and Research
- Hedgehog Signaling Pathway Studies
- Safe Handling of Antineoplastic Drugs
- Skin and Cellular Biology Research
- Whipple's Disease and Interleukins
- Advanced Image Fusion Techniques
- Infant Development and Preterm Care
- Veterinary Pharmacology and Anesthesia
- Genetic and rare skin diseases.
- Lipid metabolism and disorders
- Opioid Use Disorder Treatment
- Ultrasound in Clinical Applications
- Liver Disease Diagnosis and Treatment
The First Affiliated Hospital, Sun Yat-sen University
2016-2024
University Hospitals of Cleveland
2020-2024
Peking Union Medical College Hospital
2012-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2024
Guiyang Medical University
2024
Sun Yat-sen University
2015-2024
First Affiliated Hospital of Anhui Medical University
2021-2024
Anhui Medical University
2021-2024
Case Western Reserve University
2017-2022
University School
2022
The Lrrk2 gene modulates the course of infections in mice a sex-dependent manner.
Indications for placental submission are variable. Established guidelines largely based on expert opinion, and there is a need more evidence-based criteria. A 10-year database of term placentas was used to evaluate indications significantly associated with pathology. Lesions in 5 categories were separated into high- low-grade subgroups. Two additional high-grade lesions also evaluated. chronic monitoring abnormalities, severe preeclampsia, pregestational diabetes, maternal signs infection,...
•We conducted prostate autopsies to investigate latent cancer epidemiology and measure the accuracy of biopsy.•In recent decades, prevalence has increased in China.•Transperineal transrectal biopsies exhibited similar sensitivities but different preferential areas.•Both methods biopsy missed one-third cases with large lesions, most which were anterior prostate. Prostate detected by autopsy is named cancer. As repertoire clinical cancer, may better reflect disease burden. Unlike specimens,...
To investigate the clinical value of chromosomal microarray analysis (CMA) in prenatal diagnosis abnormalities fetal growth restriction (FGR) cases.The ultrasound findings 107 FGR cases subjected to invasive diagnostic testing from March 2013 October 2015 were retrospectively reviewed. Karyotyping was performed all cases, and CMA 80 cases.In our study, karyotype identified aberrations 9.3% (10/107) while detected 18.8% (15/80) cases. achieved a 11.4% detection rate among with normal...
<b><i>Aims:</i></b> To review pregnancy outcomes, complication rates and neonatal neural development of selective termination procedures for complicated monochorionic (MC) twins. <b><i>Methods:</i></b> This was a retrospective the pregnancies that underwent reduction with radiofrequency ablation (RFA) bipolar cord coagulation (BCC) in our institution. <b><i>Results:</i></b> Forty-eight cases BCC remaining 45 RFA. Overall...
Abstract Background The contribution of genetic variants to congenital heart defects (CHDs) has been investigated in many postnatal cohorts but described few prenatal fetus cohorts. Overall, specific especially copy number (CNVs) leading CHDs are somewhat diverse among different cohort studies. In this study, a total 1118 fetuses with confirmed were recruited from three units over 5-year period, composing 961 singleton pregnancies and 157 twin pregnancies. We performed chromosomal microarray...
Leuprorelin acetate microspheres, a common gonadotropin-releasing hormone agonist, have certain clinical benefits for prostate cancer (PCa). The present study aimed to compare the efficacy and safety of generic branded leuprorelin microspheres in patients with PCa. retrospective, observational included 116 PCa who received (Boennuokang
Conventional karyotyping has been a routine method to identify chromosome abnormalities in products of conception. However, this process is being transformed by single nucleotide polymorphism (SNP) array, which advantages over karyotyping, including higher resolution and dispensing with cell culture. Therefore, the purpose study was evaluate advantage high-resolution SNP array identifying genetic aberrations conception.We consecutively collected 155 conception specimens, 139 from...
Psoriasis, a chronic inflammatory condition of the skin, is characterized by an atypical proliferation epidermal keratinocytes and immune cell infiltration. Orientin flavonoid monomer with potent anti-inflammatory activities. However, therapeutic effects orientin on psoriasis underlying mechanisms have not been elucidated.
Abstract Objective To investigate the detection rate of 16p11.2 recurrent microdeletions in fetuses with abnormal ultrasound findings and determine common carrying deletion. Methods This study reviewed 2262 consecutive who underwent prenatal chromosomal microarray analysis between October 2014 December 2016. Cases microdeletion were further genetically analyzed, their clinical features reviewed. Results The was identified 12 fetuses, had skeletal malformations (5/12), cardiovascular (4/12),...
Objective To evaluate whether discrepant copy number variations (CNVs) contribute to the risk for discordant congenital anomalies in monochorionic diamniotic (MCDA) twins. Methods We conducted a parallel testing using both G-banding standard karyotyping and chromosomal microarray analysis (CMA) with Affymetrix CytoScan HD array MCDA twins malformations. Results During study period, 193 malformations were detected followed up. Multiple cardiac defects most frequently among fetuses Among all...
Reportedly, various urine manipulations can be performed by opioid use disorder (OUD) patients who are on buprenorphine/naloxone medications to disguise their non-compliance the treatment. One type of manipulation is known as “spiking” adulteration, directly dipping a film into urine. Identifying this has been aim many previous studies. These studies have revealed adulterations through inappropriately high levels “buprenorphine” and “naloxone” very small amount “norbuprenorphine.” So, does...
Uniparental disomy is the inheritance of a homologous chromosome pair or part chromosomes from only one parent. However, clinical significance uniparental and difference among prognosis involvement different remain unclear.
Prenatal ultrasound is the preferred modality for diagnosing fetal congenital heart disease. Given issues of physician proficiency and hospital distribution, we propose a dynamic sequential cross-sectional scanning (SCS) to explore feasibility cardiac screening by sonographers with less than 5 years experience in ultrasound. Twenty residents were randomly divided into two groups, receiving training American Institute Ultrasound Medicine (AIUM) echocardiography SCS method. According needs...
This study aimed to estimate the associations of copy number variants (CNVs) with fetal kidney ultrasound anomalies. A total 331 fetuses anomalies who underwent prenatal chromosomal microarray analyses were enrolled. The classified into groups isolated and nonisolated or according types anomalies.Clinically significant CNVs identified in 3.4% 7.3% anomalies, respectively. more frequently abnormal embryonic migration kidneys (6.6%) than malformations renal parenchyma (4.7%) urinary collecting...
Mineral exploiting information is an important indicator to reflect regional mineral activities. Accurate extraction of this essential management and environmental protection. In recent years, there are increasingly large number pieces research on land surface classification by conducting multi-source remote sensing data. However, in order achieve the best result, how select optimal feature combination key issue. This study creatively combines Out Bag data with Recursive Feature Elimination...
To assess the clinical characteristics of fetal aneuploidy between dichorionic twins (DCT) and monochorionic (MCT) undergoing invasive prenatal diagnosis.Twin fetuses diagnosis were enrolled in this study. All twin classified into 2 groups according to chorionicity. The rates different compared.This study included 1,714 (857 sets pairs); among them, 1,190 DCT 524 MCT. Overall, rate was 4.7% (56/1,190) 3.4% (18/524) Sixty-four (86.5%, 64/74) aneuploidies occurred only one fetus pairs. In DCT,...
Cytomegalovirus (CMV) infection is one of the most common congenital viral infections. Classically associated placental findings include chronic villitis with plasma cells, stromal hemosiderin deposition, and identification inclusions in villous endothelial cells. We present a case confirmed CMV that lacked these classical findings, but demonstrated massive perivillous fibrin deposition (MPVFD). This first report MPVFD. MPVFD an uncommon lesion adverse fetal outcomes high risk recurrence....
Familial Rubinstein-Taybi syndrome (RSTS) with recurrent RSTS siblings and apparently unaffected parents is rare; such cases might result from parental somatic and/or germline mosaicism. Parental low-level (&lt;10%) mosaicism in the CREBBP-associated family has not been reported. Here, we present our studies of a Chinese two parents. We detected apparent de novo variant (DNV) c.3235C&gt;T (p.Gln1079 * ) CREBBP via trio whole-exome sequencing. High-depth next-generation sequencing...
Ectodermal Dysplasia is a diverse group of inherited disorders characterized by congenital defect in two or more ectodermal structures. Due to fairly low incidence, the best our knowledge there are few clues that can assist making an effective prenatal ultrasound diagnosis. Currently, diagnosis dysplasia depends on fetal genetic test combined with family history. In this case report, we present remarkable image, testing, history, and relevant exams stillbirth.A multipara 22-week singleton...