A5100777592- Pulmonary Hypertension Research and Treatments
- COVID-19 Clinical Research Studies
- Cerebrovascular and Carotid Artery Diseases
- Parkinson's Disease Mechanisms and Treatments
- Venous Thromboembolism Diagnosis and Management
- Vascular Anomalies and Treatments
- Cardiovascular Function and Risk Factors
- Peripheral Artery Disease Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Liver Disease and Transplantation
- Cardiovascular Issues in Pregnancy
- Eicosanoids and Hypertension Pharmacology
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Nuclear Receptors and Signaling
- MRI in cancer diagnosis
- Acute Ischemic Stroke Management
- Angiogenesis and VEGF in Cancer
- Intracranial Aneurysms: Treatment and Complications
- Spinal Fractures and Fixation Techniques
- Peptidase Inhibition and Analysis
- Cardiac tumors and thrombi
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Thermal Regulation in Medicine
- Cancer-related molecular mechanisms research
State Key Laboratory of Respiratory Disease
2018-2025
Binzhou University
2025
Binzhou Medical University
2025
West China Second University Hospital of Sichuan University
2013-2024
Sichuan University
2013-2024
Guiyang Medical University
2024
Union Hospital
2011-2023
Huazhong University of Science and Technology
2012-2023
First Affiliated Hospital of Guangzhou Medical University
2018-2023
Guangzhou Medical University
2018-2023
Background The coronavirus disease 2019 (COVID-19) outbreak is evolving rapidly worldwide. Objective To evaluate the risk of serious adverse outcomes in patients with COVID-19 by stratifying comorbidity status. Methods We analysed data from 1590 laboratory confirmed hospitalised 575 hospitals 31 provinces/autonomous regions/provincial municipalities across mainland China between 11 December and January 2020. composite end-points, which consisted admission to an intensive care unit, invasive...
The novel coronavirus disease 2019 (COVID-19) has become a global health emergency. cumulative number of new confirmed cases and deaths are still increasing out China. Independent predicted factors associated with fatal outcomes remain uncertain.The goal the current study was to investigate potential risk from COVID-19 through multivariate Cox regression analysis nomogram model.A retrospective cohort 1,590 hospitalized patients throughout China established. prognostic effects variables,...
Since December, 2019, the coronavirus disease 2019 (COVID-19) has spread globally, infecting more than 1 million people and causing 70 000 deaths.1Kim JY Choe PG Oh Y et al.The first case of novel pneumonia imported into Korea from Wuhan, China: implication for infection prevention control measures.J Korean Med Sci. 2020; 35: e61Crossref PubMed Scopus (281) Google Scholar, 2Wu Z McGoogan JM Characteristics important lessons outbreak in summary a report 72 314 cases Chinese Center Disease...
During the outbreak of coronavirus disease 2019 (COVID-19), consistent and considerable differences in severity mortality rate patients treated Hubei province compared to those other parts China have been observed. We sought compare clinical characteristics outcomes being inside outside province, explore factors underlying these differences.
Abstract Objective To evaluate the spectrum of comorbidities and its impact on clinical outcome in patients with coronavirus disease 2019 (COVID-19). Design Retrospective case studies Setting 575 hospitals 31 province/autonomous regions/provincial municipalities across China Participants 1,590 laboratory-confirmed hospitalized patients. Data were collected from November 21 st , to January 2020. Main outcomes measures Epidemiological variables (in particular, comorbidities) extracted medical...
Patients with coronavirus disease 2019 (COVID-19) exhibit a spectrum of respiratory symptoms like cough and dyspnea.1-3 Airway mucus is an adhesive viscoelastic gel composed mostly high-molecular-weight mucous glycoproteins water, which important in maintaining lung function health, pathological hypersecretion may cause airway obstruction lead to distress. Mucin (MUC) are the major macromolecular components mucus, classified into two types: gel-forming secreted MUC5AC membrane-tethered...
Trimethylamine N-oxide (TMAO), a metabolite derived from intestine microbial flora, enhances vascular inflammation in variety of cardiovascular diseases, and the bacterial communities associated with TMAO metabolism are higher pulmonary hypertension (PH) patients. The effects on PH, however, have not been elucidated. In present study, circulating was found to be elevated intermediate high-risk PH patients when compared healthy control or low-risk monocrotaline-induced rat models, elevated;...
Genome-wide association studies (GWASs) have identified numerous susceptibility loci for Parkinson's disease (PD), but its genetic architecture remains underexplored in populations of non-European ancestry. To identify variants associated with PD the Chinese population, we performed a GWAS using whole-genome sequencing (WGS) 1,972 cases and 2,478 controls, replication study total 8209 9454 controls. We one new risk variant rs61204179 (P
Pulmonary hypertension (PH) patients typically present with a diminished platelet count, but the role of platelets in development and progression PH remains unclear. Our research has uncovered that within animal models PH, depletion or transfusion from healthy donors reduced pulmonary vascular thickening. In contrast, PH-affected subjects into animals led to an augmentation Transcriptomic analysis revealed exhibited upregulation genes associated cellular adhesion, activation, adhesion....
Hypoalbuminemia is commonly observed in patients with severe Coronavirus Disease 2019 (COVID-19) and independently associated adverse outcomes. However, the efficacy of albumin administration on clinical prognosis these remains uncertain. This multicenter retrospective study enrolled 458 COVID-19 four medical centers from December 1, 2022, to June 2024. Clinical features laboratory variables were collected through electronic records. The cohorts divided into two groups: non-albumin...
Alteration in microbiota composition of respiratory tract has been reported the progression many chronic lung diseases, yet, correlation and causal link between disease development pulmonary hypertension (PH) remain largely unknown. This study aims to define compare pharyngeal swab samples patients with PH reference subjects. A total 118 79 subjects were recruited, collected sequence 16S ribosomal RNA (16S rRNA) V3-V4 region microbiome. The relative abundances profoundly different from Ace...
Pulmonary arterial smooth muscle cell (PASMC) phenotype switching, which is characterized by changes in (SM)-specific gene expression, contributes to vascular remodeling pulmonary hypertension. In addition, it has been shown that the transcription of SM-specific genes modulated cytoskeleton rearrangement. However, intracellular mechanisms and signaling pathways regulate these relationships are largely unknown. present study, we aimed investigate roles phosphoinositide 3-kinase (PI3K) protein...
Mutations of the glucocerebrosidase (GBA) gene have reportedly been associated with Parkinson disease (PD) in various ethnic populations such as Singaporean, Japanese, Formosan, Canadian, American, Portuguese, Greek, Brazilian, British, Italian, Ashkenazi Jewish, southern and southwestern Chinese. The purpose this study is to determine central China whether or not reported GBA mutations remain PD. In project, we conducted a controlled cohort 208 Chinese PD patients 298 controls for three...
Inflammation activation is accompanied by tumor growth, migration, and differentiation. Photodynamic therapy (PDT) can trigger an inflammatory response to cause negative feedback of inhibition. In this paper, a feedback-elevated antitumor amplifier developed constructing self-delivery nanomedicine for PDT cascade anti-inflammation therapy. Based on the photosensitizer chlorin e6 (Ce6) COX-2 inhibitor indomethacin (Indo), prepared via molecular self-assembly technology without additional drug...
CD146 is highly expressed in various malignant tumors and associated with the poor prognosis. However, role of clear cell renal carcinoma (ccRCC) still unknown. This study aimed to identify ccRCC by integrated bioinformatics analysis.CD146 mRNA expression methylation data was examined using TIMER, UALCAN, MethSurv databases. paraffin-embedded tissues (140 cancer samples 140 paracancer tissues) from our cohort were immunohistochemistry assay. The LinkedOmics database used signaling pathways...
The interleukin-21 receptor (IL-21R) can be upregulated in endothelial cells (EC) from ischemic muscles mice following hind-limb ischemia (HLI), an experimental peripheral arterial disease (PAD) model, blocking this ligand–receptor pathway-impaired STAT3 activation, angiogenesis, and perfusion recovery. We sought to identify mRNA microRNA transcripts that were differentially regulated HLI, based on the muscle having intact, or reduced, IL-21/IL21R signaling. In comparison, 200 mRNAs...
Excitotoxicity is one of the most extensively studied processes neuronal death and plays an important role in Alzheimer's disease. In present study, protective effects Gossypium herbaceam extracts (GHE) on learning memory impairment