A5012941622- Catalytic C–H Functionalization Methods
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Cyclopropane Reaction Mechanisms
- Catalytic Alkyne Reactions
- Asymmetric Hydrogenation and Catalysis
- Catalytic Cross-Coupling Reactions
- Synthesis and Catalytic Reactions
- Radical Photochemical Reactions
- Oxidative Organic Chemistry Reactions
- Synthetic Organic Chemistry Methods
- Chemical synthesis and alkaloids
- COVID-19 Clinical Research Studies
- Crystallography and molecular interactions
- Sulfur-Based Synthesis Techniques
- Synthesis and bioactivity of alkaloids
- Click Chemistry and Applications
- Synthesis and pharmacology of benzodiazepine derivatives
- Berberine and alkaloids research
- Advanced Synthetic Organic Chemistry
- Fluorine in Organic Chemistry
- Synthesis of Organic Compounds
- COVID-19 and healthcare impacts
- Inflammasome and immune disorders
- Microbial Natural Products and Biosynthesis
Northwest A&F University
2016-2025
Northwest Institute of Mechanical and Electrical Engineering
2024
Third Affiliated Hospital of Guangzhou Medical University
2020-2021
Guangzhou Medical University
2020-2021
First Affiliated Hospital of Guangzhou Medical University
2020
State Key Laboratory of Respiratory Disease
2020
Ewha Womans University
2016
Lanzhou University
2009-2014
Lanzhou Institute of Chemical Physics
2011
Shaanxi Normal University
2007
Background The coronavirus disease 2019 (COVID-19) outbreak is evolving rapidly worldwide. Objective To evaluate the risk of serious adverse outcomes in patients with COVID-19 by stratifying comorbidity status. Methods We analysed data from 1590 laboratory confirmed hospitalised 575 hospitals 31 provinces/autonomous regions/provincial municipalities across mainland China between 11 December and January 2020. composite end-points, which consisted admission to an intensive care unit, invasive...
During the outbreak of coronavirus disease 2019 (COVID-19), consistent and considerable differences in severity mortality rate patients treated Hubei province compared to those other parts China have been observed. We sought compare clinical characteristics outcomes being inside outside province, explore factors underlying these differences.
Take two: α-Diazocarbonyl compounds display a diverse pattern of reactivity upon palladium-catalyzed reaction with esters. Esters bearing an alkynyl group on the carbonyl carbon atom lead to two different CC bonds at same in single operation through decarboxylation and migratory insertion, whereas aromatic benzylic acid derivatives afford esters O-substituted quaternary center. Detailed facts importance specialist readers are published as ”Supporting Information”. Such documents...
An efficient palladium-catalyzed coupling of propargylic carbonates (1) with N-tosylhydrazones (2, 2′) has been carried out. A wide range N-sulfonylhydrazones (3) and multisubstituted vinylallenes (4) can be obtained selectively by using either [PdCl2(CH3CN)2] or [Pd2(dba)3] as catalysts. (dba=trans,trans-dibenzylideneacetone, dppp=propane-l,3-diylbis(diphenylphosphane), Ts=4-toluenesulfonyl.)
A new and efficient metal-free cascade cyclization of 1,6-enynes with aldehydes is developed for the synthesis tricyclic fluorene derivatives. The reaction involves a radical process one C(sp(2))-C(sp(2)) two C(sp(2))-C(sp(3)) bonds are formed simultaneously in pot by using PivOH TBHP.
Activation of C2 and C3 indoles by molecular iodine (I(2)) base followed in situ reaction with 1-(2-tosylaminophenyl)ketones or 2-tosylaminobenzaldehyde can afford highly substituted indolo(2,3-b)quinolines moderate to excellent yields (up 99%). The provides a metal-free selective difunctionalization indoles. synthetic potential the protocol has been illustrated synthesis neocryptolepine its 11-methyl analogue.
Two different cyclic amino esters are synthesized by palladium-catalyzed cross-coupling reaction of diazoesters with N-substituted-2-iodoanilines. Aryldiazoacetates lead to α-amino an α-quaternary carbon centre in the presence CO. Additionally, arylvinyldiazoacetates afford α,β-unsaturated γ-amino esters.
Extensive effort has been expended to utilize π-allyl palladium complexes as electrophilic allyl donor intermediates in cooperative dual catalysis, but their counteranions such carboxylates and alkoxides are almost always discarded waste. We have developed a Pd(0)/Rh(II) dual-catalysis system that utilizes both nucleophilic counteranion functionalities inherent the starting allylic substrates. In this redox-compatible Pd(0) Rh(II) catalysts selectively activate substrates...
Interleukin6 (IL-6) is a key driver of hyperinflammation in COVID-19, and its level strongly correlates with disease progression. To investigate whether variability COVID-19 severity partially results from differential IL-6 expression, functional single-nucleotide polymorphisms (SNPs) were determined Chinese patients mild or severe illness. An Asian-common haplotype defined by promoter SNP rs1800796 intronic SNPs rs1524107 rs2066992 correlated severity. Homozygote carriers C-T-T variant at...
The first gold(III)-catalyzed regioselective oxidation/cycloisomerization of diynes 1 with pyridine N-oxide as the oxidant was developed, providing a range synthetically valuable and useful fused furan derivatives 3 in moderate to good yields. Control experiments confirmation structure minor products 5 suggest that this chemistry concerted oxidation/SN2′-type addition/cyclization process via β-gold vinyloxypyridinium intermediate putative vinyl cation intermediate.
A Brønsted acid-catalyzed 2-alkynyl-4-hydroxybenzaldehydes and primary amines to 6(2 H )-isoquinolinones in one-pot has been reported. This protocol tolerates various commercially available amines, including chiral amino alcohols acids.
A Rh(II)/Pd(0) dual-catalysis strategy that promotes the regio-divergent transformations of alkylic oxonium ylides from α-diazo-β-ketoesters has been developed. Polyfunctionalized dihydrofuran-3-ones with an O-substituted quaternary carbon center and 2,3-disubstituted benzofurans can be selectively obtained in good to excellent yields at room temperature via one-pot synthesis. The reaction mechanism was further investigated by control, stepwise, crossover experiments.
An efficient two component cycloaddition reaction to synthesize various substituted quinoline derivatives was developed. Ynone 1 functionalizated by N-oxide attacking the C3-oxetium site and C3-site regioselectively give 3 4. Analogues 3k 4v have a high binding constant with Hg2+ in CH3CN.
A novel relay Rh(II)/Pd(0) dual catalysis strategy that promotes the divergent reaction of α-diazo-carbonyl compounds with allylic carboxylates for selective construction cyclic all-quaternary carbon centers has been developed. This binary catalyst system rendered domino C–H insertion/allylic alkylation process under mild conditions. Remarkably, catalytic shows good selectivity and excellent tolerance to various functionalities is operationally simple.
An attractive palladium-catalyzed three-component reaction of ortho-amino aryl diazo esters, allyl carboxylates, and carbon monoxide (CO) has been developed. This catalytic system rendered domino carbene migratory insertion carbonylation. Remarkably, 2-indolones 3 with a C3 all-carbon quaternary center can be selectively obtained in good to excellent yields via one-pot synthesis, which two different C-C bonds one C-N bond were formed straightforward manner.
Mal zwei: α-Diazocarbonyl-Verbindungen reagieren unter Palladiumkatalyse in vielfältiger Weise mit Estern. Am Carbonyl-Kohlenstoffatom alkinylierte Ester bilden zwei unterschiedliche C-C-Bindungen an demselben Kohlenstoffatom einem einzigen Schritt durch Decarboxylierung und migratorische Insertion, aromatische benzylische Säurederivate ergeben hingegen Aryl- bzw. Benzylester O-substituiertem quartärem Kohlenstoffzentrum. Detailed facts of importance to specialist readers are published as...
A facile gold-catalyzed oxidation terminal alkynes to synthesize substituted dihydronaphthalen-2(1H)-ones 3 and phenanthrenols 5 was realized. Various useful structures drug precursors were generated in up 99% yield under mild condition low catalyst loading.
Abstract The efficient construction of quaternary carbon centers is a challenging task due to their enhanced structural complexity. Although the catalytic gem‐ difunctionalization α ‐diazo carbonyl compounds via metal‐carbenoids well‐documented, developing new methods access which are difficult or unattainable in monocatalysis highly desirable. Dual catalysis where two different catalysts work concurrently has emerged as powerful strategy achieve reactivity and selectivity. In this review,...
Abstract A chemo‐selective Rh(II)/Pd(0) dual catalysis that promotes one‐pot synthesis of C3‐quaternary allylic oxindoles from N ‐aryl‐ α ‐diazo‐ β ‐ketoamides and functionalized allyl carbonates in good to excellent yields has been developed. The efficiency this transformation relies on the choice strategy enabled cascade intramolecular aryl C−H insertion alkylation under mild conditions. magnified image
A cooperative Rh(II)/Pd(0) dual-catalysis strategy that promotes a cyclization/allylic alkylation cascade of stable α-diazo-δ-keto-esters has been developed. Highly substituted 3(2H)-furanones with C2-quaternary center can be obtained efficiently under mild conditions via one-pot synthesis. Remarkably, this binary catalytic system shows high chemo-, regio-, and stereoselectivity excellent tolerance to various functionalities.
An efficient and chemoselective transformation of β-amido ynones to 3-acyl-substituted quinolones 2 3-H-quinolones 4 has been developed. In this reaction, β-cyclic amido can be selectively transformed into in anhydrous EG via a selective C═O bond cleavage, 1,5-O migration, C═C recombination process. The practical approach reaction renders it viable alternative for the construction various quinolones.
A relay Rh(ii)/Pd(0) dual catalysis that enables domino [1,2]-sigmatropic rearrangement/allylic alkylation of α-diazo tertiary alcohols is described. This transformation represents a highly efficient method for the one-pot synthesis α-quaternary β-keto-esters under mild conditions, in which two separate C-C σ-bonds at carbenic center were formed straightforward manner.
Copper(I)-catalyzed ‘click chemistry’ using acetylene gas was successfully explored under mild conditions. 1-Substituted-1,2,3-triazoles were conveniently synthesized from the corresponding aromatic and aliphatic azides.