A AgSCF3-mediated radical cascade cyclization/trifluoromethylthiolation of 1,6-enynes triggered by a C–C triple bond is developed. This protocol also provides another opportunity to construct valuable trifluoromethylthio-substituted polycyclic fluorene system through the formations one C–SCF3 and two bonds in single step.

A palladium-catalyzed C-H allylation of electron-deficient polyfluoroarenes with gem-difluorinated cyclopropanes is reported. It provides a useful and facile approach to 2-fluoroallylic in moderate excellent yields high Z-selectivity. In addition, this new has good functional group compatibility broad substrate scope.

A highly diastereoselective dearomatization of indoles via palladium-catalyzed decarboxylative alkynyl termination was developed. This protocol provides dissimilar tetracyclic and tetrasubstituted indoline scaffolds bearing congested stereocenters, which led to operationally simple conditions, short time, broad substrate scope. Additionally, this reaction system could be scaled gram quantities in a satisfactory yield diastereoselectivity.

A strategy for the synthesis of iodocarbazoles through a tandem iodocyclization with migration and aromatization is presented. This sequential cascade process concisely conducted at room temperature in short time. Moreover, obtained halides can be further applied to palladium-catalyzed coupling reactions, which act as important intermediates building other valuable compounds.

In this article, we propose a novel approach to achieve spectrum prediction, parameter fitting, inverse design and performance optimization for the plasmonic waveguide coupled with cavities structure (PWCCS) based on artificial neural networks (ANNs).The Fano resonance plasmon induced transparency effect originated from PWCCS have been selected as illustrations verify effectiveness of ANNs.We use genetic algorithm network architecture select hyper-parameters ANNs.Once ANNs are trained by...

A novel strategy for the synthesis of 2-arylated oxazole derivatives <italic>via</italic> palladium/copper-catalyzed decarbonylative heteroarylation amides C–N bond activation by ground-state destabilization is reported.

Abstract A series of novel halogen‐functionalized imidazolium halides were successfully designed and synthesized by grafting halogenated hydrocarbons on the side chain applied to catalyze intermolecular dehydration alcohols. Under metal‐free, acid‐free, solvent‐free, mild conditions in an air atmosphere, 1‐(4‐bromobutyl)‐3‐methylimidazolium bromide was found efficiently etherification monohydric alcohols diols, as well synthesis certain unsymmetrical ethers. Interestingly, immiscibility...

Mesoporous carbon spheres with densely and accessible atomic Co–Nx sites are employed as efficient air electrodes for neutral Mg–air batteries.

Abstract A convenient strategy is presented for the easy preparation of a series 2 H ‐chromenes under mild conditions through iodocyclization readily accessible propynols. In addition, various 4‐chromanones can be synthesized p ‐toluenesulfonic acid catalyzed cascade cyclization with high efficiency (yields up to 99 %). Our developed reaction systems are proven have good functional‐group applicability and scaled gram quantities in satisfactory yields. These also provide new synthetic two...

Ferrous and sulfur ions are essential elements for the human body, which play an active role in maintaining body's normal physiology. Meanwhile, mussel-inspired polydopamine (PDA) possesses good hydrophilicity biocompatibility. In present work, ferrous sulfide embedded into nanoparticles (PDA@FeS NPs) was designed synthesized via a simple predoping polymerization-coprecipitation strategy intelligent PDA matrix successfully prevented oxidation agglomeration of FeS nanoparticles. Importantly,...

The low-molecular-weight and easily prepared N-thiobenzoyl 1-methyl-histidine methyl ester 3k was utilized to efficiently catalyze the kinetic resolution of racemic secondary alcohols. Comparison conformations amide catalyst 3c thioamide made understand origin improvement enantioselectivity by modification.

A strategy for the synthesis of spiroketal compounds through a tandem iodocyclization 1-(2-ethynylphenyl)-4-hydroxybut-2-yn-1-one derivatives is presented. This reaction could proceed under very mild conditions in short time and avoid use expensive toxic metal catalysts. Moreover, resulting halides can be further exploited by subsequent palladium-catalyzed coupling reactions, which act as important intermediates building other valuable compounds.

An efficient cobalt-catalyzed C-S/C-Se bond formation method for the synthesis of benzo[b]thio/selenophene-fused imidazo[1,2-a]pyridines has been developed. This protocol was catalyzed by an inexpensive and commercially available cobalt catalyst without extra reductant while using thiocyanate selenocyanate as sulfur selenium sources. A wide range were obtained in good yields.

We disclose herein an efficient and facile method for the synthesis of SF5-containing isoquinolinediones with all-carbon quaternary stereocenter via intramolecular pentafluorosulfanylation acrylamides using SF5Cl as a reagent. The protocol proceeds under mild reaction conditions enjoys broad substrate scope, wide functional group compatibility, high atom- step-economy. A radical mechanism involving SF5 cascade addition/cyclization is proposed.

Inhibition of the epidermal growth factor receptor (EGFR) has been proved to be one most promising strategies for treatment non-small cell lung cancers. A series 2-aryl-4-amino substituted quinazoline derivatives were designed and synthesized with purpose overcome L858R/T790M/C797S (CTL) triple mutant drug resistance biological activity inhibition CTL kinases EGFR wild type (WT) evaluated. Three compounds (20, 24 27) showed excellent inhibitory activities against (IC50 < 1 µM) high...

Abstract A method to synthesize benzofurylselenocyanates, benzothienylselenocyanates and indolylselenocyanates via electrophilic selenocyanogen cyclization was established. This sequential process conducted under mild conditions in a short time. protocol successfully applied late‐stage functionalization of bioactive molecules. Notablely, the selenocyanate can be converted into other valuable Se‐containing compounds showed antitumor activity human hepatoma cells HepG2. magnified image

A palladium-catalyzed cis -selective carboalkylation of internal alkynes with cyclobutanols is reported, providing a useful and facile approach to alkyl-substituted olefins moderate good yields excellent stereoselectivity.

A strategy for the synthesis of 6,9-dihydropyrido[1,2-a]indoles through a cascade iodocyclization 4-(3-methyl-1H-indol-1-yl)-1,1-diphenylbut-2-yn-1-ol derivatives is presented. This reaction was conducted under very mild conditions and in short time. The reactions are metal-free, environmentally friendly give up to 94% yield. Moreover, obtained halides allow functional group diversification by palladium-catalyzed coupling reactions, which could act as potential intermediates valuable compounds.

An expedient strategy for the synthesis of 3-phosphinoylbenzofurans through a cascade electrophilic phosphination cyclization has been presented.

Micro/nanomaterials with multilayer core-shell structures are receiving widespread attention due to their potential in energy storage and conversion systems. However, simple fabrication of multilayered structured micro/nanomaterials a consistent composition still faces great challenge. Herein, one-step solvothermal method is used fabricate Cu-based metal organic framework microspheres (Cu-MOF-MCSMSs) as efficient oxygen reduction reaction (ORR) catalysts. The systematic structural evolution...