A5061625824- Microbial Natural Products and Biosynthesis
- Catalytic C–H Functionalization Methods
- Fungal Biology and Applications
- Multicomponent Synthesis of Heterocycles
- Oxidative Organic Chemistry Reactions
- Asymmetric Synthesis and Catalysis
- Asymmetric Hydrogenation and Catalysis
- Radical Photochemical Reactions
- Synthesis and Biological Evaluation
- Synthesis and Catalytic Reactions
- X-ray Diffraction in Crystallography
- Synthesis of Organic Compounds
- Crystallization and Solubility Studies
- Microbial Metabolism and Applications
- Synthetic Organic Chemistry Methods
- Sulfur-Based Synthesis Techniques
- Cancer therapeutics and mechanisms
- Synthesis and biological activity
- Chemical Synthesis and Analysis
- Cyclopropane Reaction Mechanisms
- Bioactive Compounds and Antitumor Agents
- Inorganic Fluorides and Related Compounds
- Fluorine in Organic Chemistry
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactions of Organic Compounds
Xinxiang Medical University
2016-2025
Shanghai Institute of Technology
2024
Nantong University
2024
First Affiliated Hospital of Xinxiang Medical University
2024
Universiti Sains Malaysia
2023
Xinxiang University
2013-2021
State Council of the People's Republic of China
2021
Scripps Research Institute
2015-2017
Kunming Institute of Botany
2006-2009
Chinese Academy of Sciences
2006-2009
A conformationally flexible template for the meta-C-H olefination of benzoic acids was designed through both experimental and computational efforts. The newly favors a silver-palladium heterodimer low barrier transition state, demonstrates that it is feasible to lengthen templates so as achieve meta-selectivity when distance between functional handle native substrate target C-H bond decreases. Analysis ortho-, meta-, para-C-H cleavage states determined new conformation optimizes interaction...
Fluorescence-enhanced supra-amphiphiles based on (WP5)
Herein for the first time, we disclose a practical and straightforward approach to access α-SF5 ketones via direct oxypentafluorosulfanylation of alkynes with SF5Cl oxygen under acidic conditions by one step. The protocol features mild reaction conditions, broad substrate scope, good functional group compatibility can be applied late-state functionalization complex natural products pharmaceuticals. A radical mechanism involving SF5 addition triple bonds followed O2 capture is proposed.
Four new prenylxanthones and five known compounds were isolated from the plant endophytic fungus<italic>Emericella</italic>sp. XL029. Biological assays revealed that showed selective inhibitory activity against bacterial fungal strains.
A novel and efficient entrance to the pyrimidine skeleton has been presented via α,β-dehydrogenation deamination of tertiary alkylamines. This I2-catalyzed dehydrogenative multicomponent procedure utilizes simple aldehydes trap hidden enamine intermediates suspend generation azadienes from amidines, enabling difunctionalization a vicinal C(sp3)–H bond. These studies provide valuable possibilities for introduction aliphatic substituents show how switch new reactive modality.
Herein we present evidence for the therapeutic potential of colonization factor (CF)-specific egg yolk antibodies (IgY) potentially treating acute and recurring Clostridium difficile infection (CDI) in humans. The study involved cloning, expressing as 6×His-tagged proteins Escherichia coli, Ni-affinity purifying three previously identified CFs (FliC, FliD Cwp84) from C. difficile. recombinant CF antigens were then used to immunize Leghorn chickens CF-specific IgY prepared their eggs....
Four new natural products possessing vibralactone skeleton, 1,5-secovibralactone (1), B (2), C (3) and acetylated (4), together with known compound (5), had been isolated from cultures of the basidiomycete Boreostereum vibrans. The structures 1—4 were elucidated on basis spectroscopic methods. absolute configuration 1 was suggested to be S by computational
With triethylamine as a vinylene source, convenient protocol for the regioselective synthesis of β,γ-nonsubstituted 2-arylquinolines from aldehydes and arylamines has been accomplished. The deaminative cyclization is also extended to long-chain tertiary alkylamines, enabling diverse alkyl groups be concurrently installed into pyridine rings. This process demonstrates new conversion pathway simultaneous dual C(sp3)-H bond functionalization amines, wherein transient acyclic enamines generated...
We disclose herein an efficient and facile method for the synthesis of SF5-containing isoquinolinediones with all-carbon quaternary stereocenter via intramolecular pentafluorosulfanylation acrylamides using SF5Cl as a reagent. The protocol proceeds under mild reaction conditions enjoys broad substrate scope, wide functional group compatibility, high atom- step-economy. A radical mechanism involving SF5 cascade addition/cyclization is proposed.
The preparation of cis-2,3-dihydrobenzofuranols with two stereocenters through aqueous asymmetric transfer hydrogenation (ATH) benzofuranones the metal catalyst Ru(II) via dynamic kinetic resolution (DKR) has been developed. A variety α-alkyl were transformed to obtain optically pure 2,3-dihydrobenzofuran-3-ols excellent enantioselectivities and acceptable yields under mild conditions.
Abstract A versatile and efficient strategy for the total synthesis of anti‐HIV‐1 agent concentricolide its analogues daldinins A, B, C has been established. This offers a mild facile access to these benzo annulated compounds, bearing multiple stereocenters in good yield with 99% enantiomeric excess ( ee ) 93% diastereomeric de values. Construction corresponding syn dihydrobenzofuran phthalide groups can be achieved one step by Noyori's asymmetric transfer hydrogenation, via dynamic kinetic...
Enantioselective electrophilic difluoromethylation by phase transfer catalysis.
A protocol for visible-light-induced C-H acylation selectively at the C6 position of purine nucleosides with aldehydes under photocatalyst-free conditions was established herein. This allows green, mild, and efficient functionalization various a broad range alkyl aryl aldehydes.
Water has therefore become an attractive medium for many organic reactions, not only the advantages con-cerning avoidance of expensive, catalysts and solvents, but also some unique reactivity selectivity. In recent years, use molecular iodine in synthesis received considerable attention due to powerful catalytic activity various transformations.
An efficient and enantioselective aerobic oxidation of 4-substituted pyrazolones has been developed by phase transfer catalysis. Using visible light as the driving force O2 (in air) oxidant, broad scopes (38 examples) bearing an oxygen-attached carbon stereocenter at C-4 position were obtained in high yields (up to 98%) excellent enantioselectivities 93% ee) under mid conditions. The ready availability catalyst, ease operation, low-cost eco-friendly nature highlighted practical utility this...
In the present study, we successfully developed an efficient thiocyanation of carbonyl compounds by using low-toxicity and inexpensive ammonium thiocyanate as source under visible light in air (O2) at room temperature. This unified strategy is very facile for various compound derivatives (β-keto esters, β-keto amides, pyrazo-5-ones, isoxazol-5-ones, etc.). More importantly, reaction proceeded smoothly without addition a photocatalyst strong oxidant, ultimately minimizing production chemical...
In this paper, we developed a highly enantioselective alkylation of 4-substituted pyrazolones catalyzed by phase-transfer catalysis. Cheap halohydrocarbons were employed as electrophilic alkylationg agents, and propargyl, allyl, benzyl products with all-carbon quaternary stereocenters afforded excellent enantioselectivities good yields. We found that the unique structures catalyst (hydrogen bond donors C-9 hydroxyl group amide group, triphenyl at NH-position) important for...
Two new azulene pigments, 7-(1-hydroxy-1-methylethyl)-4-methylazulene-1-carbaldehyde (1) and 4-methyl-7-(1-methylethyl)azulene-1-carboxylic acid (2), were isolated from the fruiting bodies of basidiomycete Lactarius hatsudake, together with one known pigment (3). Their structures determined by spectroscopic means (including 2D-NMR) HR-TOF-MS experiments.