A5037885698- Viral Infectious Diseases and Gene Expression in Insects
- Insect Resistance and Genetics
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Invertebrate Immune Response Mechanisms
- Crystallography and molecular interactions
- Virus-based gene therapy research
- Bladder and Urothelial Cancer Treatments
- Entomopathogenic Microorganisms in Pest Control
- Plant Virus Research Studies
- Silk-based biomaterials and applications
- Malaria Research and Control
- Immune cells in cancer
- DNA Repair Mechanisms
- Cancer Immunotherapy and Biomarkers
- Robotic Mechanisms and Dynamics
- Urinary and Genital Oncology Studies
- Autophagy in Disease and Therapy
- Aquaculture disease management and microbiota
- Higher Education and Teaching Methods
- Polymer Surface Interaction Studies
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Hydraulic and Pneumatic Systems
- Glycosylation and Glycoproteins Research
Minnan University of Science and Technology
2023-2025
Jiangsu University
2013-2025
Cummins (United Kingdom)
2025
Novel (United States)
2023-2024
Hunan University of Science and Technology
2011-2024
Sinopec (China)
2022-2024
Hunan University of Traditional Chinese Medicine
2024
Shandong University
2024
Central South University
2021-2023
Second Xiangya Hospital of Central South University
2021-2023
We report the molecular identification of a sialic acid-independent host-parasite interaction in Plasmodium falciparum malaria parasite invasion RBCs. Two nonglycosylated exofacial regions human band 3 RBC membrane were identified as crucial host receptor binding C-terminal processing products merozoite surface protein 1 (MSP1). Peptides derived from region inhibited RBCs by P. falciparum. A major segment (5ABC) bound to native MSP1(42) and blocked with intact vitro. Recombinant MSP1(19)...
Oral clearance of lamotrigine, an antiepileptic drug commonly used in pregnant women, is increased pregnancy by unknown mechanisms. In this study, we show that 17β-estradiol (E<sub>2</sub>) up-regulates expression UDP glucuronosyltransferase (UGT) 1A4, the major enzyme responsible for elimination lamotrigine. Endogenous mRNA levels UGT1A4 estrogen receptor (ER) α-negative HepG2 cells were induced 2.3-fold E<sub>2</sub> treatment presence ERα expression. enhanced transcriptional activity a...
Two new species from China, Bryochoerus liupanensis sp. nov. and Pseudechiniscus chengi (Tardigrada: Heterotardigrada: Echiniscidae), are reported. is characterized by median plates 1 2 divided into four parts while plate 3 three parts, two lateral on each side of all plates. The differs intermedius in having a different cuticular sculpture by: head faceted, cephalic papilla dome-shaped, pseudosegmental with longitudinal fold, including the dorsal legs ornamentation composed dense round...
Solar ultraviolet radiation (UV) may cause DNA damage. We first report in this study that the large subunit ribosome protein RPL12, from Bomby mori (BmRPL12), participated UV-induced damage repair. BmRPL12 enhanced resistance of Escherichia coli (E. coli) to UV and facilitated faster repair silkworm cells. mainly existed cytoplasm dimer forms, N-terminal nuclear export signal was crucial for localization BmRPL12. After radiation, unable localize at sites participate directly might indirectly...
Aim Immune checkpoint inhibitors (ICIs) have updated the treatment landscape for patients with advanced malignancies, while their clinical prospect was hindered by severe immune-related adverse events (irAEs). The aim of this study to research association between gut microbiome diversity and occurrence ICI-induced irAEs. Patients Method We prospectively obtained baseline fecal samples data from treated anti-PD-1 as monotherapy or in combination chemotherapy antiangiogenesis regardless lines....
Immune cells can protect against tumor progression by killing cancer cells, while aberrant expression of the immune checkpoint protein PD-L1 (programmed death ligand 1) in facilitates escape and inhibits anti-tumor immunotherapy. As a serine/threonine kinase, CK2 (casein kinase 2) regulates multiple pathways, it is still unclear effect on escape. Here found that ING4 induced autophagic degradation inhibites non-small cell lung (NSCLC) increasing T activity. However, clinical analysis...
In Plasmodium falciparum malaria, erythrocyte invasion by circulating merozoites may occur via two distinct pathways involving either a sialic acid-dependent or -independent mechanism. Earlier, we identified nonglycosylated exofacial regions of band 3 termed 5ABC and 6A as an important host receptor in the acid-independent pathway. 5ABC, major segment this receptor, interacts with 42-kDa processing product merozoite surface protein 1 (MSP142) through its 19-kDa C-terminal domain. Here, show...
Heterostructured porous FeS<sub>2</sub>/CuS nanospheres exhibit enhanced reaction kinetics, excellent rate capability and desirable long-term cycling stability performance.
Background: Given the limitations of traditional pharmacology pedagogical method, diverse novel teaching methods have been widely explored. In this study, we performed a network meta-analysis (NMA) to evaluate effects different strategies in education. Methods: Literature databases were searched from their inception November 2022, and studies screened according predefined inclusion exclusion criteria extract important information. Outcomes, including theoretical test scores, experimental...
Blockade of the programmed death 1 (PD-1)/ ligand (PD-L1) immune checkpoint could increase antitumor immunotherapy for multiple types cancer, but response rate patients is about 10%-40%. Peroxisome proliferator activated receptor γ (PPARγ) plays an important role in regulating cell metabolism, inflammation, immunity, and cancer progression, while mechanism PPARγ on escape still unclear. Here we found that expression exhibits a positive correlation with activation T cells non-small-cell lung...
Polyphenols are known to interact with starch form the V‐type inclusion complex or noninclusive complex. It is hypothesized that addition of polyphenols could improve properties Chinese yam ( Dioscorea opposita Thunb.) starch, and complexes be regulated by controlling additive amount polyphenols. To test this hypothesis, effect varying ferulic acid (FA) concentrations (3%, 9%, 15%) on structural characterization physicochemical (CYS) was investigated. X‐ray diffraction analysis showed CYS FA...
<div class="section abstract"><div class="htmlview paragraph">The purpose of the paper is to study impact dither on how improve pressure control capability in common rail system. The directly operating inlet metering valve and making flow accuracy. correlation between was analyzed. Optimizing control. To overcome hysteresis problem its stability rapidity PID strategy based were applied system many papers have introduced logical. But application seldom specified for valve. With...
A nuclear export signal (NES) is a cluster of hydrophobic amino acids that can maintain the dynamic shuttling target proteins between nucleus and cytoplasm. Bioinformatics analysis showed region 92PLLLHKFLLA in Bm65 very likely to be an NES may involved production infectious virions. In this study, we generated several mutations Bm65, which were further used generate recombinant viruses study their roles viral propagation. Subcellular revealed sequence was transport Bm65. Mutations could...
In this study, we present our discovery that the combination of dichloromethyl methyl ether (DCME) and Lewis acid, a reaction condition traditionally used for Rieche formylation, is capable activating...
ABSTRACT This study investigates the role of second language (L2) pride—an understudied affective factor—in shaping learners’ learning motivation and involvement with informal digital English (IDLE). Drawing on questionnaire data from 1388 Chinese university EFL students, employs structural equation modeling to examine relationships between L2 pride, motivational self‐system components (ideal self ought‐to self), IDLE practices. Results reveal that pride directly influences both students’...
Bone metastasis after failure of castration therapy is the main reason death in patients with prostate cancer (PCa). Therefore, full awareness mechanism PCa and discovery new therapeutic targets are necessary. Studies showed that lncRNA was involved development cancer. However, its potential role molecular still unclear. YKL-40 an 18 glycosyl hydrolase family protein encoded by CHI3L1, which invasion various tumors. A previous study authors found related to cells. cause abnormal expression...