A5100780055- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
- Receptor Mechanisms and Signaling
- Osteoarthritis Treatment and Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Synthesis and biological activity
- Immune cells in cancer
- vaccines and immunoinformatics approaches
- Lipid metabolism and disorders
- Spaceflight effects on biology
- RNA Research and Splicing
- Circular RNAs in diseases
- Plant Gene Expression Analysis
- Hippo pathway signaling and YAP/TAZ
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Synthesis and Biological Evaluation
- Antimicrobial Peptides and Activities
- HIV Research and Treatment
- Biochemical and Structural Characterization
- Cancer therapeutics and mechanisms
- Biochemical and biochemical processes
- Laser Applications in Dentistry and Medicine
- Cancer-related molecular mechanisms research
- Computational Drug Discovery Methods
Second Hospital of Hebei Medical University
2023-2025
Hebei Medical University
2023-2025
Beijing Tongren Hospital
2024
Capital Medical University
2024
Tulane University
2024
Tsinghua University
2016-2024
Tianjin University
2024
Changchun University of Chinese Medicine
2024
Chonnam National University
2023-2024
Chaozhou Central Hospital
2023
One emerging and exciting topic in robotics research is the design of micro-/nanoscale robots for biomedical operations. Unlike industrial that are developed primarily to automate routine dangerous tasks, nanorobots designed complex, physiologically relevant environments, tasks involve unanticipated biological events. Here, a biologically interfaced nanorobot reported, made magnetic helical nanomotors cloaked with plasma membrane human platelets. The resulting biomimetic possess coating...
Abstract The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo differentiation into osteoblasts. This process plays a crucial role in bone formation and homeostasis is regulated by two intricate processes: cell signal transduction transcriptional gene expression. Various essential signaling pathways, including Wnt, BMP, TGF-β, Hedgehog, PTH, FGF, Ephrin, Notch, Hippo, Piezo1/2, play critical facilitating osteoblast differentiation, formation, homeostasis. Key...
Abstract Preservatives are essential components in cosmetic products, but their safety issues have attracted widespread attention. There is an urgent need for safe and effective alternatives. Antimicrobial peptides (AMPs) part of the innate immune system potent antimicrobial properties. Using machine learning-assisted rational design, we obtained a novel antibacterial peptide, IK-16-1, with significant activity maintaining based on β-defensins. IK-16-1 has broad-spectrum properties against...
The innovative bioconversion route of lignin derivatives to homoeriodictyol meets the atom-economic concept, and paves a green, sustainable way for both valorization production valuable flavonoids.
The growth plate (GP) comprising sequentially differentiated cell layers is a critical structure for bone elongation and regeneration. Although several key regulators in GP development have been identified using genetic perturbation, systematic understanding still limited. Here, we used single-cell RNA-sequencing (RNA-seq) to determine the gene expression profiles of 217 single cells from GPs developed bioinformatics pipeline named Sinova de novo reconstruct physiological both temporal...
As the most common degenerative joint disease, osteoarthritis (OA) contributes significantly to pain and disability during aging. Several genes of interest involved in articular cartilage damage OA have been identified. However, direct causes are poorly understood. Evaluating public human RNA-seq dataset showed that CBFB (subunit a heterodimeric Cbfβ/Runx1, Runx2, or Runx3 complex) expression is decreased patients with OA. Here, we found chondrocyte-specific deletion Cbfb tamoxifen-induced...
Effective evaluation of multi-hop tool use is critical for analyzing the understanding, reasoning, and function-calling capabilities large language models (LLMs). However, progress has been hindered by a lack reliable datasets. To address this, we present ToolHop, dataset comprising 995 user queries 3,912 associated tools, specifically designed rigorous use. ToolHop ensures diverse queries, meaningful interdependencies, locally executable detailed feedback, verifiable answers through novel...
Sphingosine kinase 1 (SPHK1) is a member of the SPHK family, enzymes essential for phosphorylation sphingosine to sphingosine-1-phosphate (S1P). Previous studies have revealed important roles SPHK1 in inflammatory, anti-apoptotic, immune processes, and cancer. Although predictive significance possible gliomas recently been examined, precise molecular mechanisms remain unclear. We comprehensively examined investigated its correlation with glioma survival time using different datasets. The...
PKMYT1 is a crucial regulator of the cell cycle, particularly involved in G2/M transition through inhibitory phosphorylation CDK1, and promising therapeutic target for cancer therapy. Data mining Roche kinome screen database identified hit characterized by 100% activity at 10 μM concentration, which was further validated with enzymatic assay showing double-digit nanomolar potency. The featured quinolinone central core phenol headgroup. replacement problematic headgroup an indazole moiety...
Illumina is the leading sequencing platform in next-generation (NGS) market globally. In recent years, MGI Tech has presented a series of new sequencers, including DNBSEQ-T7, MGISEQ-2000 and MGISEQ-200. As complex application NGS, cancer-detecting panels pose increasing demands for high accuracy sensitivity data analysis. this study, we used same capture DNA libraries constructed based on protocol to evaluate performance Nextseq500 platforms. We found that two platforms had consistency...
βARs (β-adrenergic receptors) are prototypical GPCRs (G protein-coupled that play a pivotal role in sympathetic regulation. In heart cells, β1AR signaling mediates global response, including both l-type Ca2+ channels the sarcolemma/T tubules and RyRs (ryanodine SR (sarcoplasmic reticulum). contrast, β2AR local with little effect on function of proteins.To investigate relationship between β1ARs β2ARs.Using whole-cell patch-clamp analyses combined confocal imaging, we found activation...
Arylsulfatase D (ARSD) belongs to the sulfatase family and plays a crucial role in maintaining proper structure of bone cartilage matrix. Although several researches have revealed functions ARSD tumor progression, prognostic value glioma related mechanisms not been fully investigated.We performed pan-cancer analysis ARSD, investigated relationship between expression overall survival (OS) multiple datasets. ROC curves nomograms were created investigate predictive capacity ARSD. Immune...
<b><i>Introduction:</i></b> Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by relapsed eczema and serious pruritus. High-mobility group box 1 protein (HMGB1) nuclear-binding serves as an alarmin to promote responses. <b><i>Methods:</i></b> In this study, we established AD mouse model topical use of MC903 on ears then used specific HMGB1-binding peptide cIY8 HMGB1 inhibitor glycyrrhizin investigate fibroblast...
The TGF-β1/Smad3-signaling pathway and gender differences were investigated in alcoholic liver fibrosis. Mice divided into female normal, model, male model groups. Liver injury fibrosis assessed using histopathology serology. Western blotting was performed to analyze the expression of relevant factors. HSC-T6 cells estradiol + saline, ethanol, testosterone ethanol groups, similar assessments conducted vitro. Compared with group, group exhibited significantly increased GPT, GOT, TNF-α, IL-6,...
Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a high-grade (HGNEC) accounting for 3% of primary lung cancer, and characterized by strong invasion, high heterogeneity, extremely poor prognosis. At present, the diagnosis treatment LCNEC remains controversial refer to therapeutic strategy small cancer (SCLC), lacking precise therapy. Recently, genetic analysis clinical trials gradually emerged, providing more evidence treatment. Here, we review diagnosis, molecular characteristics,...
Flavonoids, such as homoeriodictyol derivatives, hold significant value in nutraceuticals, foods, and pharmaceuticals. Microbial synthesis of these products has emerged a powerful approach due to its sustainability environmental...
Osteoblasts must acquire a considerable capacity for folding unfolded and misfolded proteins (MPs) to produce large amounts of extracellular matrix maintain bone homeostasis. MP accumulation contributes cellular apoptosis disorders. Photobiomodulation therapy has been used treat diseases, but the effects decreasing MPs with photobiomodulation remain unclear. In this study, we explored efficacy 625 nm light-emitting diode irradiation (LEDI) reduce in tunicamycin (TM) induced-MC3T3-E1 cells....
Human immunodeficiency virus type 1 (HIV-1) is responsible for the majority of HIV infections worldwide, and we still lack a cure this infection. Blocking interaction HIV-1 its primary receptor CD4 one strategy identifying new anti-HIV-1 entry inhibitors. Here report discovery novel ligand that can inhibit infection via CD4. Biological computational analyses inhibitor analogs, using bioactivity evaluation, Rule Five (RO5), comparative molecular field analysis (CoMFA)/comparative similarity...
The interaction of SDF-1α (also known as CXCL12) with the CXCR4 receptor plays a critical role in retention hematopoietic stem cells (HSCs) bone marrow. viral macrophage inflammatory protein-II (vMIP-II), human herpesvirus-8 (HHV-8)-encoded chemokine, can bind and inhibit endogenous ligand-induced calcium responses cell migration. Previously, we used bivalent ligand approach to link synthetically two unnatural D-amino acid peptides derived from N-terminus vMIP-II (DV1 DV3, respectively)...