A5100783308- Bone and Dental Protein Studies
- Genetic diversity and population structure
- dental development and anomalies
- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Phylogenetic Studies
- Advances in Cucurbitaceae Research
- Periodontal Regeneration and Treatments
- Rice Cultivation and Yield Improvement
- Crustacean biology and ecology
- Plant Disease Resistance and Genetics
- RNA modifications and cancer
- Plant Pathogens and Fungal Diseases
- Fish Biology and Ecology Studies
- Plant and animal studies
- Lepidoptera: Biology and Taxonomy
- Crop Yield and Soil Fertility
- Connective tissue disorders research
- Enterobacteriaceae and Cronobacter Research
- Heat shock proteins research
- Hormonal Regulation and Hypertension
- Yeasts and Rust Fungi Studies
- Plant Molecular Biology Research
- Oral and Maxillofacial Pathology
- Aquaculture Nutrition and Growth
- Coconut Research and Applications
University of Michigan
2021-2024
Anhui Agricultural University
2022
University of Science and Technology of China
2020
Institute of Agro-Products Processing Science and Technology
2020
Chinese Academy of Agricultural Sciences
2020
Institute of Food Science and Technology
2020
Sichuan Academy of Agricultural Sciences
2019
The University of Tokyo
2018
Xinjiang Academy of Agricultural Sciences
2009-2016
Shanghai Ocean University
2013-2015
Hami melon (Cucumis melo) is the most important crop grown in north-western provinces of China. In order to elucidate genetic and molecular basis developmental changes related size, flesh, sugar sour content, we performed a transcriptome profiling its fruit development. Over 155 000 clean reads were mapped MELONOMICS genome, yielding total 23 299 expressed genes. Of these, 554 genes specifically flowers, 3260 flesh tissues. The 7892 differentially (DEGs) development mediated diverse...
Scytalidium auriculariicola is the causative pathogen of slippery scar disease in cultivated cloud ear fungus, Auricularia polytricha. In present study, mitogenome S. was sequenced and assembled by next-generation sequencing technology. The circular 96,857 bp long contains 56 protein-coding genes, 2 ribosomal RNA 30 transfer genes (tRNAs). high frequency A T used codons contributed to AT content (73.70%) mitogenome. Comparative analysis indicated that base composition number introns varied...
Mutations in Dentin Sialophosphoprotein (DSPP) are known to cause, order of increasing severity, dentin dysplasia type-II (DD-II), dentinogenesis imperfecta (DGI-II), and type-III (DGI-III). DSPP mutations fall into two groups: a 5′-group that affects protein targeting 3′-group shifts translation the −1 reading frame. Using whole-exome sequence (WES) analyses Single Molecule Real-Time (SMRT) sequencing, we identified disease-causing 12 families. Three novel: c.53T>C/p.(Val18Ala);...
Hereditary dentin defects are conventionally classified into three types of dentinogenesis imperfecta (DGI) and two dysplasia (DD). Mutations in the sialophosphoprotein (DSPP) gene have been identified to cause DGI type II III DD II; therefore, these not different conditions, but rather allelic disorders. In this study, we recruited families with varying clinical phenotypes from DGI-III DD-II performed mutational analysis by candidate or whole-exome sequencing. Three novel mutations...
According to historical records, ethnic Hui in China obtained substantial genetic components from western Eurasian populations during their Islamization. However, some scholars believed that the ancestry of people were native Chinese populations. In this context, formation is due simple cultural diffusion rather than demic diffusion. study, we examined forensic and population application 30 InDel loci Ningxia Autonomous Region, Northwest China. Genotype analysis 129 unrelated individuals...
Next-generation sequencing enables genome-wide genotyping of a large population and further facilitates the construction genetic linkage map. Low-coverage whole-genome has been employed for map in several species. However, this strategy generally requires available high-quality reference genomes and/or designed inbred pedigree lines, which restrict scope application non-model unsequenced Here, using torafugu (Takifugu rubripes) as test model, we propose new ultrahigh-density low-coverage...
mutations cause X-linked amelogenesis imperfecta (AI), known as AI types IE, IIB, and IIC in Witkop's classification, characterized by hypoplastic (reduced thickness) and/or hypomaturation hardness) enamel defects. In this study, we conducted whole exome analyses to unravel the disease-causing for six families. Splicing assays, immunoblotting, quantitative RT-PCR were investigate molecular cellular effects of mutations. Four
Amelogenesis imperfecta (AI) is a heterogeneous group of rare genetic disorders affecting tooth enamel formation. Here we report an identification novel de novo missense mutation [c.817_818delinsAT, p.(Ala273Met)] in the SP6 gene, causing non-syndromic autosomal dominant AI. This second paper on amelogenesis caused by mutation. Interestingly identified this study 2-bp variant at same nucleotide positions as first report, but with AT instead AA insertion. Clinical phenotype was much more...
Amelogenesis imperfecta (AI) is a rare genetic condition affecting the quantity and/or quality of tooth enamel. Hypomaturation AI characterized by brownish-yellow discoloration with increased opacity and poorly mineralized enamel prone to fracture attrition. We recruited three families affected hypomaturation performed whole exome sequencing selected individuals in each family. Bioinformatic analysis Sanger identified confirmed mutations segregation families. Family 1 had novel homozygous...
Amelogenesis imperfecta (AI) is a collection of rare genetic conditions affecting tooth enamel. The affected enamel can be insufficient quantity and/or altered quality, impacting structural content, surface integrity and coloration. Heterozygous mutations in ENAM result hypoplastic AI without other syndromic phenotypes, with variable expressivity reduced penetrance, unlike AI-associated genes. In this study, we recruited Caucasian family AI. Mutational analysis (using whole exome sequencing)...
Amelogenesis imperfecta (AI) is a heterogeneous collection of hereditary enamel defects. The affected can be classified as hypoplastic, hypomaturation, or hypocalcified in form. A better understanding normal amelogenesis and improvements our ability to diagnose AI through genetic testing realized more complete knowledge the genes disease-causing variants that cause AI. In this study, mutational analysis was performed with whole exome sequencing (WES) identify etiology underlying...
摘要:
Amelogenesis imperfecta (AI) is a group of rare genetic diseases affecting the tooth enamel. AI characterized by an inadequate quantity and/or quality enamel and can be divided into three major categories: hypoplastic, hypocalcified hypomaturation types. Even though there are some overlapping phenotypes, typically has yellow to brown discoloration with dull appearance but normal thickness indicating less mineralized matrix. In this study, we recruited four Turkish families performed...
In this study, we sequenced and analyzed the complete mitogenome Dahira obliquifascia to compare mitogenomic structures reconstruct phylogenetic relationships. The sequence of D. is circular, 15,939 bp in size encodes 13 protein-coding genes (PCGs), 2 ribosomal RNA (rRNA), 22 transfer (tRNA) a control region (CR). Nucleotide composition highly biased toward A + T nucleotides (80.3%). All (PCGs) initiate with standard start codon ATN terminate typical stop TAA/TAG. Phylogenetic analyses were...